Full-duplex mode in amplify-and-forward relay channels: outage probability and ergodic capacity

This paper investigates the outage probability and ergodic capacity performances for full-duplex mode in two-way amplify-andforward relay channels. The two-way relay channels which consist of two source nodes and a single relay node working in full-duplex mode, are assumed as independent and identically distributed as Rayleigh fading. The self-interference or loop interference of the relay is unavoidably investigated for full-duplex mode. And the close-form expressions for the outage probability and ergodic capacity of full-duplex mode are derived, considering both loop interference and the coefficients of two-way relay amplify-andforward channels. To further facilitate the performance of full-duplex mode, the half-duplex modes over different transmission time slots are analyzed. Simulation results point out the effect of loop interference on outage probability and ergodic capacity of twoway amplify-and-forward relay channels with full-duplex mode and show that full-duplex mode can achieve better performance in terms of capacity and even outperform half-duplex modes in the presence of loop interference

A Wireless Location System in LTE Networks

Personal location technologies are becoming important with the rapid development of Mobile Internet services. In traditional cellular networks, the key problems of user location technologies are high-precision synchronization among different base stations, inflexible processing resources, and low accuracy positioning, especially for indoor environment. In this paper, a new LTE location system in Centralized Radio Access Network (C-RAN) is proposed, which makes channel and location measurement more available, allocation of baseband processing resources more flexible, and location service capability opening. The location system contains more than two antenna clusters, and each of them gets time-difference-of-arrival (TDOA) of sounding reference signals (SRSs) from different antennas. Then, based on data provided by location measurement units (LMUs), the location information server calculates TDOAs and derives the users’ position. Furthermore, a new location algorithm is raised which can achieve distributed antennas collaboration and centralized location computing. And an improved optimized algorithm with the best TDOA selection is proposed. Finally, simulations are given out to verify the efficiency of the proposed algorithm in this LTE location system

Full-Duplex Mode in Amplify-and-Forward Relay Channels: Outage Probability and Ergodic Capacity

This paper investigates the outage probability and ergodic capacity performances for full-duplex mode in two-way amplify-and-forward relay channels. The two-way relay channels which consist of two source nodes and a single relay node working in full-duplex mode, are assumed as independent and identically distributed as Rayleigh fading. The self-interference or loop interference of the relay is unavoidably investigated for full-duplex mode. And the close-form expressions for the outage probability and ergodic capacity of full-duplex mode are derived, considering both loop interference and the coefficients of two-way relay amplify-and-forward channels. To further facilitate the performance of full-duplex mode, the half-duplex modes over different transmission time slots are analyzed. Simulation results point out the effect of loop interference on outage probability and ergodic capacity of two-way amplify-and-forward relay channels with full-duplex mode and show that full-duplex mode can achieve better performance in terms of capacity and even outperform half-duplex modes in the presence of loop interference

Anti-Ferroptosis: A Promising Therapeutic Method for Thyroid Cancer

At present, many problems remain to be solved in studying the pathogenesis of thyroid cancer. Ferroptosis is a programmed cell death mode discovered in recent years, and many studies have found that ferroptosis plays a significant role in the prognosis and progression of thyroid cancer. The researchers showed that ferroptosis-related genes are essential in diagnosing thyroid cancer. Therefore, this paper summarizes some pathological and clinical characteristics of thyroid cancer and makes a series of combs on the relationship between ferroptosis and the basis and function of thyroid cancer, thus providing specific ideas for the diagnosis and treatment of thyroid cancer

Platelet microparticles-containing miR-4306 inhibits human monocyte-derived macrophages migration through VEGFA/ERK1/2/NF-κB signaling pathways

Platelets are major sources of microparticles (MPs) in peripheral bloodstream, and platelet-secreted MPs (P-MPs) transfer biological information to neighboring cells. In the present study, we found that the platelet- and P-MPs-derived microRNA-4306 (miR-4306) expression were downregulated in coronary artery disease (CAD) and platelet-derived miR-4306 was an independent poor prognostic factor in CAD. Plasma miRNA-4306 mainly cofractionated with MPs instead of Argonaute2 complexes or HDL. P-MPs could effectively deliver miR-4306 into human monocyte-derived macrophages (HMDMs). MiR-4306 noticeably inhibited the HMDMs migration in vitro and reduced the number of macrophage cells in cardiac tissue in myocardial infarction mice. This functional impact of miR-4306 was mediated directly through VEGFA to inhibit ERK/NF-κB signaling. In conclusion, our study suggested that intercellular transfer of miR-4306 by platelet microparticles inhibited the HMDMs migration through VEGFA/ERK1/2/NF-κB signaling pathways

Delayed Ischemic Preconditioning Attenuated Renal Ischemia-Reperfusion Injury by Inhibiting Dendritic Cell Maturation

Background/Aims: Even though delayed ischemic preconditioning (DIPC) has been reported to produce renal protection, the underlying mechanism remains poorly understood. We reported that a 15-minute renal ischemic preconditioning (IPC) 4 days before subsequent ischemia-reperfusion attenuated renal injury Kidney dendritic cells (DCs) are abundant in the renal tubulointerstitium and, depending on their status, can induce immune activation or tolerance. The aim of the present study was to investigate the role of DCs in IPC of the kidney. Methods: Mouse kidneys were challenged by transient brief episodes of sublethal ischemia followed by subsequent prolonged ischemia. DC abundance and maturation in the spleen and kidney were measured by flow cytometry and immunohistochemical staining. To confirm the function of mature DCs in the renoprotective effect of IPC on renal ischemia-reperfusion injury the A2 adenosine receptor (A2AR) antagonist SCH58261 was administered to stimulate DC maturation prior to assessment of renal functional and histological injury and the inflammatory reaction. Results: Compared with sham-operated animals, preconditioned mice had a reduced injury with less CD11c+ cells, lower levels of the pro-inflammatory cytokine IL-17 and reduced expression of the mature DC marker CCR7. Preconditioned mice also produced more of the anti-inflammatory cytokine IL-10. Both renal cells and splenocytes from these mice had more DCs (CD45+/CD11c+/F4/80-), but fewer of these DCs were mature (CD45+/CD11c+/ F4/80-/MHC-II+/CD80+) compared with those from sham-treated animals, suggesting that the immunomodulatory effect of renal ischemic preconditioning is both local and systemic. Additionally, injection of the A2AR antagonist SCH58261 reversed IPC-induced inhibition of DC maturation and mitigated the protective effect of preconditioning, suggesting that DC maturation contributes to immune cell-mediated ischemic preconditioning. Conclusion: Our results show that DIPC of the kidney provides local and systemic immunosuppression by inhibiting DC maturation and hence mediates a renal protective effect