Aspirin Use and Common Cancer Risk:A Meta-Analysis of Cohort Studies and Randomized Controlled Trials

BackgroundWhether aspirin use can decrease or increase cancer risk remains controversial. In this study, a meta-analysis of cohort studies and randomized controlled trials (RCTs) were conducted to evaluate the effect of aspirin use on common cancer risk.MethodMedline and Embase databases were searched to identify relevant studies. Meta-analyses of cohort studies and RCTs were performed to assess the effect of aspirin use on the risk of colorectal, gastric, breast, prostate and lung cancer. Cochran Q test and the I square metric were calculated to detect potential heterogeneity among studies. Subgroup meta-analyses according to exposure categories (frequency and duration) and timing of aspirin use (whether aspirin was used before and after cancer diagnosis) were also performed. A dose-response analysis was carried out to evaluate and quantify the association between aspirin dose and cancer risk.ResultsA total of 88 cohort studies and seven RCTs were included in the final analysis. Meta-analyses of cohort studies revealed that regular aspirin use reduced the risk of colorectal cancer (CRC) (RR=0.85, 95%CI: 0.78-0.92), gastric cancer (RR=0.67, 95%CI: 0.52-0.87), breast cancer (RR=0.93, 95%CI: 0.87-0.99) and prostate cancer (RR=0.92, 95%CI: 0.86-0.98), but showed no association with lung cancer risk. Additionally, meta-analyses of RCTs showed that aspirin use had a protective effect on CRC risk (OR=0.74, 95%CI: 0.56-0.97). When combining evidence from meta-analyses of cohorts and RCTs, consistent evidence was found for the protective effect of aspirin use on CRC risk. Subgroup analysis showed that high frequency aspirin use was associated with increased lung cancer risk (RR=1.05, 95%CI: 1.01-1.09). Dose-response analysis revealed that high-dose aspirin use may increase prostate cancer risk.ConclusionsThis study provides evidence for low-dose aspirin use for the prevention of CRC, but not other common cancers. High frequency or high dose use of aspirin should be prescribed with caution because of their associations with increased lung and prostate cancer risk, respectively. Further studies are warranted to validate these findings and to find the minimum effective dose required for cancer prevention

Development of A New Type of 2-DOF Piezo-Actuated Pseudo-Decoupled Compliant Mechanism for Elliptical Vibration Machining

Currently, the elliptical vibration cutting/coining (EVC2) has been widely employed in fabricating various functional microstructure surfaces applied in many significant engineering fields. Therefore, for this study, a novel type of two-degree-of-freedom (2-DOF) piezoelectrically actuated pseudo-decoupled compliant mechanisms (PDCMs) with non-orthogonal decoupling structures, which can exactly generate the strict ellipse trajectories, was developed for improving the forming accuracies of the EVC2 microstructures. First, the compliance matrices of 2-DOF PDCMs were theoretically modeled using the popular finite beam-based matrix modeling (FBMM) and the matrix-based compliance modeling (MCM) methods, then finite element analysis (FEA) was adopted to verify the effectiveness of the built compliance model for the 2-DOF PDCM with arbitrary structure parameters. Second, the static FEA method was employed to systematically reveal the dependencies of the tracking accuracies of the elliptical trajectories on the decoupling structures of 2-DOF PDCMs. Moreover, their main dynamic performances were also investigated through the FEA-based harmonic response analysis and modal analysis. On these bases, the critical angle of the decoupling structure was optimally set at 102.5° so that the PDCMs had minimum shape distortions of the ellipse trajectories. Thirdly, a series of experiments was conducted on this PDCM system for practically investigating its kinematic and dynamic performances. The actual aspect ratio between the major axis and minor axis of the ellipse trajectory was approximately 1.057, and the first-order and second-order resonant frequencies were 863 Hz and 1893 Hz, respectively. However, the obtained testing results demonstrated well the effectiveness and feasibility of 2-DOF PDCM systems in precisely tracking the ellipse trajectories with different geometric parameters. Several critical conclusions on this study are summarized in detail in the final section of this paper

Development of dissipative elastic metamaterials based on the layered cantilever-in-mass structure for attenuating the broad spectrum vibrations

In this paper, the layered cantilever-in-mass structures (LCIMs) will be theoretically investigated to reveal the effects of the layered structures on band gaps, which have great potential to bring in many useful material properties without much increasing the manufacturing difficulty by stacking the damped layers or other different component layers. Firstly, the negative effective mass model of LCIMs is derived based on the mass-in-mass model, which is applied to analyze the effective parameters of band gaps in terms of the geometrical features and material properties, the analytical results indicate the negative effective masses of LCIMs depend highly on the material parameter and thicknesses of each constituent layers. Then the LCIMs consist of the same thickness layers are further researched, which has found that their resonance frequency are independent on the layer thickness, and the numeric values of resonance frequencies are between the maximum and minimum local resonance frequency of their constituent layers. To validate the above analytical model, the three-dimensional model and the two-dimensional shell model of LCIMs are constructed in COMSOL Multiphysics. The obtained results show well agreement with the derived model in both the three-dimensional model and shell model. Finally, the dissipative LCIMs modeled by stacking the damped layers and metal layers are studied and discussed

A Novel Type of Boundary Extraction Method and Its Statistical Improvement for Unorganized Point Clouds Based on Concurrent Delaunay Triangular Meshes

Currently, three-dimensional (3D) laser-scanned point clouds have been broadly applied in many important fields, such as non-contact measurements and reverse engineering. However, it is a huge challenge to efficiently and precisely extract the boundary features of unorganized point cloud data with strong randomness and distinct uncertainty. Therefore, a novel type of boundary extraction method will be developed based on concurrent Delaunay triangular meshes (CDTMs), which adds the vertex-angles of all CDTMs around a common data point together as an evaluation index to judge whether this targeted point will appear at boundary regions. Based on the statistical analyses on the CDTM numbers of every data point, another new type of CDTM-based boundary extraction method will be further improved by filtering out most of potential non-edge points in advance. Then these two CDTM-based methods and popular α-shape method will be employed in conducting boundary extractions on several point cloud datasets for comparatively analyzing and discussing their extraction accuracies and time consumptions in detail. Finally, all obtained results can strongly demonstrate that both these two CDTM-based methods present superior accuracies and strong robustness in extracting the boundary features of various unorganized point clouds, but the statistically improved version can greatly reduce time consumption

A Novel Type of Boundary Extraction Method and Its Statistical Improvement for Unorganized Point Clouds Based on Concurrent Delaunay Triangular Meshes

Currently, three-dimensional (3D) laser-scanned point clouds have been broadly applied in many important fields, such as non-contact measurements and reverse engineering. However, it is a huge challenge to efficiently and precisely extract the boundary features of unorganized point cloud data with strong randomness and distinct uncertainty. Therefore, a novel type of boundary extraction method will be developed based on concurrent Delaunay triangular meshes (CDTMs), which adds the vertex-angles of all CDTMs around a common data point together as an evaluation index to judge whether this targeted point will appear at boundary regions. Based on the statistical analyses on the CDTM numbers of every data point, another new type of CDTM-based boundary extraction method will be further improved by filtering out most of potential non-edge points in advance. Then these two CDTM-based methods and popular α-shape method will be employed in conducting boundary extractions on several point cloud datasets for comparatively analyzing and discussing their extraction accuracies and time consumptions in detail. Finally, all obtained results can strongly demonstrate that both these two CDTM-based methods present superior accuracies and strong robustness in extracting the boundary features of various unorganized point clouds, but the statistically improved version can greatly reduce time consumption

A Novel Type of Pseudo-Decoupling Method for Two Degree-of-Freedom Piezoelectrically Driven Compliant Mechanisms Based on Elliptical Parameter Compensation

At present, a large number of two-degree-of-freedom piezoelectrically driven compliant mechanisms (2-DOF PDCMs) have been widely adopted to construct various elliptical vibration machining (EVM) devices employed in precisely fabricating functional micro-structured surfaces on difficult-to-cut materials, which have broad applications in many significant fields like optical engineering and precision manufacturing. For a higher precision of conventional 2-DOF PDCMs on tracking elliptical trajectories, a novel type of pseudo-decoupling method is proposed based on phase difference compensation (PDC). With finite element analysis (FEA), the dependences of elliptical trajectory tracking precision on PDC angles will then be investigated for optimizing PDC angles under different elliptical parameters. As the modification of the PDC-based method, another type of pseudo-decoupling method will be improved based on elliptical parameter compensation (EPC) for much higher tracking precision, an amplification coefficient and a coupling coefficient will be introduced to mathematically construct the EPC-based model. A series of FEA simulations will also be conducted on a conventional 2-DOF PDCM to calculate the amplification and coupling coefficients as well as optimize the EPC parameters under four series of elliptical parameters. The tracking precision and operational feasibility of these two new pseudo-decoupling methods on four series of elliptical trajectories will be further analyzed and discussed in detail. Meanwhile, a conventional 2-DOF PDCM will be practically adopted to build an experimental system for investigating the pseudo-decoupling performances of an EPC-based method, the input and output displacements will be measured and collected to actually calculate the amplification coefficients and coupling coefficients, further inversely solving the actual input elliptical parameters with EPC. The error distances between the expected and experimental elliptical trajectories will also be calculated and discussed. Finally, several critical conclusions on this study will be briefly summarized

Test Study on Vortex-Induced Vibration of Deep-Sea Riser under Bidirectional Shear Flow

A model test was carried out to reveal the vortex-induced vibration characteristics of a deep-sea riser under bidirectional shear flow. Bandpass filtering and modal analysis were used to process the test strain data, and the amplitude and frequency response characteristics of the vortex-induced vibration of the riser in the bidirectional shear flow field were obtained. The results of the test data analysis show that the dominant frequency of the vortex-induced vibration of the riser model under bidirectional shear flow is locked in the natural frequency of the riser and does not increase with the increase in flow velocity, that the average resistance coefficient of the riser model has little change under different flow velocities because of the distribution characteristics of the “bidirectional shear” flow field, that there is an extreme value of the shear force in the middle of the riser model, and that the Strouhal number in the transverse direction of the vortex-induced vibration under bidirectional shear flow is less than the recommended value of the current vortex-induced vibration prediction software. The obtained results provide basic data for the prediction of vortex-induced vibration and research into the fatigue analysis method of a riser under an internal wave flow field