3 research outputs found
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope
Degradation of mutant Ndc10 is mediated by the E3 ligase Doa10 at the endoplasmic reticulum/nuclear envelope membrane. An autonomous degradation motif was localized to the C-terminal region of Ndc10. The motif is composed of two indispensable elements: a hydrophobic surface of an amphipathic helix and a loosely structured, hydrophobic C-terminal tail