12 research outputs found
Further Studies on 2,4-Diamino-5-(2‘,5‘-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDS
No full text2,4-Diaminopyrido[3,2-d]pyrimidine Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii
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Side chain modified 5-deazatolate and 5-deazatetrahydrotolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. 47. N-[4-[[(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-6-yl)methyl]amino]benzoyl-L-glutamic acid, a novel a-ring analog of 2-desamino-5,8-dideazafolic acid
No full textSynthesis and Antiparasitic and Antitumor Activity of 2,4-Diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline Analogues of Piritrexim.
No full text5-Deazafolate Analogues with a Rotationally Restricted Glutamate or Ornithine Side Chain:Â Synthesis and Binding Interaction with Folylpolyglutamate Synthetase
No full textMethotrexate analogs. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analog modified at the .alpha.-carbon: chemical and in vitro biological studies
No full textNew 2,4-Diamino-5-(2‘,5‘-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity
No full textNew 2,4-Diamino-5-(2‘,5‘-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity
No full textFirst use of the Taylor pteridine synthesis as a route to polyglutamate derivatives of antifolates. 46. Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogs as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyl transferase inhibitors: synthesis and in vitro biological evaluation
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