10,418 research outputs found

    Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system

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    The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism. The mutant strains dunceM14, dunceM11, and dunceML appear to be amorphic, because they completely lack the cAMP-specific phosphodiesterase normally present in adult flies. These strains exhibit extremely high levels of cAMP. The mutant strains dunce1, dunce2, and dunceCK are hypomorphic and exhibit reduced levels of the cAMP-specific phosphodiesterase. These strains exhibit less marked increases in cAMP content compared with the three amorphic strains. The dunce2 strain possesses a residual enzyme activity that exhibits anomalous kinetics compared with those of the normal enzyme. The possibility that the dunce locus is the structural gene for the cAMP-specific phosphodiesterase is discussed

    Improved micro-contact resistance model that considers material deformation, electron transport and thin film characteristics

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    This paper reports on an improved analytic model forpredicting micro-contact resistance needed for designing microelectro-mechanical systems (MEMS) switches. The originalmodel had two primary considerations: 1) contact materialdeformation (i.e. elastic, plastic, or elastic-plastic) and 2) effectivecontact area radius. The model also assumed that individual aspotswere close together and that their interactions weredependent on each other which led to using the single effective aspotcontact area model. This single effective area model wasused to determine specific electron transport regions (i.e. ballistic,quasi-ballistic, or diffusive) by comparing the effective radius andthe mean free path of an electron. Using this model required thatmicro-switch contact materials be deposited, during devicefabrication, with processes ensuring low surface roughness values(i.e. sputtered films). Sputtered thin film electric contacts,however, do not behave like bulk materials and the effects of thinfilm contacts and spreading resistance must be considered. Theimproved micro-contact resistance model accounts for the twoprimary considerations above, as well as, using thin film,sputtered, electric contact

    Standardized Testing of Non-Standard Photovoltaic Pavement Surfaces

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    Emerging photovoltaic products have expanded the applications for the technologies into markets previously unconsidered for what was thought to be a delicate electronic product. One company leading this effort, Solar Roadways, Incorporated, is producing pavement replacing photovoltaic systems and proposing their use in everything from sidewalks to runways. Current pavement testing methods cannot be applied to these non-homogenous structures to identify if they can support the required loads. However, the standards called out specifically for pavements may be able to be translated to these products and their non-homogenous structures and non-standard materials to identify if they are able to perform similarly to standard pavements. This research modified existing test standards in several ways: rigid pavements standards for advanced loading, structural adhesive standards for shear loading, structure specific standards for moisture conditioning, and application specific standards for freeze/thaw cycling. These modifications are due to the fact that the materials in these emerging products do not have established tests to evaluate their performance in non-traditional applications. The future of electronics is dependent on product unique applications. This, in turn, requires finding methods of testing them based on application, extrapolation, or correlation to traditional material testing which enables faster product development and subsequent roll out

    The Impact of Transit Corridors on Residential Property Values

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    Most of the literature on transit corridors, such as superhighways and tunnels, focuses on the positive externality of transit access (e.g., interstate access, transit station) and fails to isolate the negative externality of the corridor itself. This empirical study examines two situations: one with both access benefits and negatives, and another without the access benefit. The findings reveal that proximity to the transit corridor alone without direct access conveys a negative impact on nearby housing values.

    Modeling U.S. Soy-Based Markets with Directed Acyclic Graphs and Bernanke Structural VAR Methods: The Impacts of High Soy Meal and Soybean Prices

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    Advanced methods that combine directed acyclic graphs with Bernanke structural vector autoregression models are applied to a monthly system of three U.S. soy-based markets: for soybeans upstream and for the two soybean co-products soy meal and soy oil further downstream. Analyses of the impulse-response function and forecast error variance decompositions provide updated estimates of market-elasticity parameters that drive these markets and updated policy-relevant information on how these monthly markets run and dynamically interact. Results characterize impacts on the three U.S. soy-based markets of increases in U.S. prices of soy meal and soybeans.Industrial Organization,

    A Review of Micro-Contact Physics for Microelectromechanical Systems (MEMS) Metal Contact Switches

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    Innovations in relevant micro-contact areas are highlighted, these include, design, contact resistance modeling, contact materials, performance and reliability. For each area the basic theory and relevant innovations are explored. A brief comparison of actuation methods is provided to show why electrostatic actuation is most commonly used by radio frequency microelectromechanical systems designers. An examination of the important characteristics of the contact interface such as modeling and material choice is discussed. Micro-contact resistance models based on plastic, elastic-plastic and elastic deformations are reviewed. Much of the modeling for metal contact micro-switches centers around contact area and surface roughness. Surface roughness and its effect on contact area is stressed when considering micro-contact resistance modeling. Finite element models and various approaches for describing surface roughness are compared. Different contact materials to include gold, gold alloys, carbon nanotubes, composite gold-carbon nanotubes, ruthenium, ruthenium oxide, as well as tungsten have been shown to enhance contact performance and reliability with distinct trade offs for each. Finally, a review of physical and electrical failure modes witnessed by researchers are detailed and examined

    ESTIMATED IMPACT OF NON-PRICE COORDINATION OF FED CATTLE PURCHASES ON MEAT PACKER PROCESSING COSTS

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    Stochastic simulation of daily slaughter level was used in conjunction with an estimated packing plant cost curve to assess potential reductions in processing costs due to improved vertical coordination between feedlots and packing plants. Results indicate that processing cost reductions of 1to1 to 5 per head may be possible. Savings result from ensuring a more stable processing volume that is near the plant's cost-minimizing level of production.cattle, cost curve, meat packing, vertical coordination, Industrial Organization, Livestock Production/Industries,
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