Nanocrystalline glass-like carbon thin films may be an useful tool in nerve cells regeneration

Abstract en el libro de Abstract de la International Conference, p. 99The interest in carbon nanomaterials with high transparency and electrical conductivity has grown within the last decade in view of a wide variety of applications, including biocompatible sensors, diagnostic devices and bioelectronic implants. The aim of this work is to test the biocompatibility of particular nanometer-thin nanocrystalline glass-like carbon films (NGLC), a disordered structure of graphene flakes joined by carbon matrixUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. We thank Prof. Arenas, Karolinska Institutet, Stockholm, Sweden, for SN4741 cell line. R.G.V. gratefully acknowledges Spanish Ministry of Science and Innovation for funding through a Ramon y Cajal fellowship

Cognitive versus emotional modulation within a Stroop paradigm in patients with schizophrenia

Background: Schizophrenia is a complex disorder involving deficits in both cognitive and emotional processes. Specifically, a marked deficit in cognitive control has been found, which seems to increase when dealing with emotional information. Aims: With the aim of exploring the possible common links behind cognitive and emotional deficits, two versions of the emotional Stroop task were administered. Method: In the cognitive-emotional task, participants had to name the ink colour (while ignoring the meaning) of emotional words. In contrast, the emotional-emotional task consisted of emotional words superimposed on emotional faces, and the participants had to indicate the emotional valence of the faces. Fifty-eight participants (29 in-patients diagnosed with schizophrenia and 29 controls) took part in the study. Results: Patients and controls showed similar response times in the cognitive-emotional task; however, patients were significantly slower than controls in the emotional-emotional task. This result supports the idea that patients show a more pronounced impairment in conflict modulation with emotional content. Besides, no significant correlations between the tasks and positive or negative symptoms were found. This would indicate that deficits are relatively independent of the clinical status of patients. However, a significant correlation between the emotional-emotional task and cognitive symptoms was found. Conclusions: These findings suggest a restricted capacity of patients with schizophrenia to deal with the attentional demands arising from emotional stimuli.Spanish Ministerio de Ciencia, Innovación y Universidades (PSI2018-098876-B-100Instituto de Salud Carlos III (PI16/00359)Instituto de Salud Carlos III (PI19/00766)5.165 JCR (2021) Q2, 56/155 Psychiatry1.214 SJR (2021) Q1, 106/556 Psychiatry and Mental HealthNo data IDR 2021UE

Photophysics behind highly luminescent two-dimensional hybrid perovskite (CH3(CH2)2NH3)2(CH3NH3)2Pb3Br10 thin films

Two-dimensional (2D) Ruddlesden–Popper perovskites have emerged as a new class of hybrid materials with high photoluminescence and improved stability compared to their three-dimensional (3D) counterparts. Studies of the photophysics of these new 2D perovskites are essential for the fast development of optoelectronic devices. Here, we study the power and temperature dependences of the photoluminescence properties of the (PA)2(MA)2Pb3Br10 hybrid perovskite. High electron–phonon coupling near room temperature was found to be dominated by longitudinal optical (LO) phonons via the Fröhlich interaction. However, we show that the presence of free carriers is also possible, with lower trapping states and higher and more stable emission compared to the 3D MAPbBr3. These characteristics make the studied 2D material very attractive for optoelectronic applications, including solar cells and light emitting diodes (LEDs). Our investigation provides new fundamental insights into the emission characteristics of 2D lead halide perovskites

The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142907/1/aji12827.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142907/2/aji12827_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142907/3/aji12827-sup-0001-FigS1.pd

MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-y (IFNy), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. We report complete refractoriness to IFNy in a subset of LCs as a result of JAK2 or IFNGR1 inactivation. A submaximal response affects another subset that shows constitutive low levels of IFNy-stimulated genes (IySGs) coupled with decreased H3K27ac (histone 3 acetylation at lysine 27) depo-sition and promoter hypermethylation and reduced IFN regulatory factor 1 (IRF1) recruitment to the DNA on IFNy stimulation. Most of these are neuroendocrine small cell LCs (SCLCs) with oncogenic MYC/MYCL1/ MYCN. The oncogenic activation of MYC in SCLC cells downregulates JAK2 and impairs IySGs stimulation by IFNy. MYC amplification tends to associate with a worse response to anti-PD1/L1 therapies. Hence alterations affecting the JAK/STAT pathway and MYC activation prevent stimulation by IFNy and may predict anti-PD1/L1 efficacy in LC