Los arrabales de la Córdoba musulmana. De las fuentes escritas a la realidad arqueológica

We present in this report our particular visión about the knowledge situation of islamic Cordoba 's suburbs, departing from a little historiographic analysis and finishing, after explaining the facts we have nomaday thanks to the archeology, with a criticism trought of the present view.Presentamos en este artículo nuestra particular visión del estado de la cuestión sobre los arrabales de la Córdoba musulmana, partiendo de un sucinto análisis historiográfico y concluyendo, tras exponer los datos con que contamos en la actualidad gracias al rigor arqueológico, con una reflexión crítica del panorama actual.Comunicación presentada a: Jornadas Cordobesas de Arqueología Andaluza. Arqueología de Al Andalus: Los palacios islámicos. XI. 2001. Córdob

Radiative properties of aerosols in Saharan dust outbreaks using ground-based and satellite data: applications to radiative forcing

We report on measurements of atmospheric transmission (ATT) and aerosol optical depth (AODT) made at three wavelengths (368, 500, and 778 nm) with a spectroradiometer placed on Tenerife (28.5°N, 16.3°W), Canary Islands. Using the National Oceanic and Atmospheric Administration (NOAA) advanced very high resolution radiometer (AVHRR) channel 1, we also measured the aerosol optical depth (AODS) and albedo over a region of the North Atlantic Ocean extending from 15°–35°N to 12°–25°W. We observe large changes in ATT and AODT when dust outbreaks pass over this region. Using all these data, we derive the asymmetry factor (g), the single-scattering albedo (ω), and the local mean AODT and we compute the direct radiative forcing ΔF attributable to mineral dust. The local radiative forcing obtained is over the ocean ΔF = −9.7 W/m2 and for the land ΔF = −4.5 W/m2 with an error of ±25%. Extending these results to global-scale averages, we obtain values of ΔF of −1.22 W/m2 over the ocean and −0.57 W/m2 over land. The forcings attributable to dust are comparable in magnitude to those reported in the literature for anthropogenic sulphate and for biomass burning aerosols.We wish to thank the Gobierno Autónomo de Canarias for its financial support by contract 4/95, the Comisi6n Interministerial de Ciencia y Tecnologia (CICYT) by contract CLI97- 0453, and the University of La Laguna by contract 1802260003. A portion of this work was carried out as part of the Atmosphere/Ocean Chemistry Experiment (AEROCE) and supported by the National Science Foundation grants ATM-9414808, ATM-9414812, and ATM- 9414846

Results of the first user program on the Homogenous Thermal Neutron Source HOTNES (ENEA / INFN)

The HOmogeneous Thermal NEutron Source (HOTNES) is a new type of thermal neutron irradiation assembly developed by the ENEA-INFN collaboration. The facility is fully characterized in terms of neutron field and dosimetric quantities, by either computational and experimental methods. This paper reports the results of the first "HOTNES users program", carried out in 2016, and covering a variety of thermal neutron active detectors such as scintillators, solid-state, single crystal diamond and gaseous detectors

Out-of-Field Doses Produced by a Proton Scanning Beam Inside Pediatric Anthropomorphic Phantoms and Their Comparison With Different Photon Modalities

Since 2010, EURADOS Working Group 9 (Radiation Dosimetry in Radiotherapy) has been involved in the investigation of secondary and scattered radiation doses in X-ray and proton therapy, especially in the case of pediatric patients. The main goal of this paper is to analyze and compare out-of-field neutron and non-neutron organ doses inside 5- and 10-year-old pediatric anthropomorphic phantoms for the treatment of a 5-cm-diameter brain tumor. Proton irradiations were carried out at the Cyclotron Centre Bronowice in IFJ PAN Krakow Poland using a pencil beam scanning technique (PBS) at a gantry with a dedicated scanning nozzle (IBA Proton Therapy System, Proteus 235). Thermoluminescent and radiophotoluminescent dosimeters were used for non-neutron dose measurements while secondary neutrons were measured with track-etched detectors. Out-of-field doses measured using intensity-modulated proton therapy (IMPT) were compared with previous measurements performed within a WG9 for three different photon radiotherapy techniques: 1) intensity-modulated radiation therapy (IMRT), 2) three-dimensional conformal radiation therapy (3D CDRT) performed on a Varian Clinac 2300 linear accelerator (LINAC) in the Centre of Oncology, Krakow, Poland, and 3) Gamma Knife surgery performed on the Leksell Gamma Knife (GK) at the University Hospital Centre Zagreb, Croatia. Phantoms and detectors used in experiments as well as the target location were the same for both photon and proton modalities. The total organ dose equivalent expressed as the sum of neutron and non-neutron components in IMPT was found to be significantly lower (two to three orders of magnitude) in comparison with the different photon radiotherapy techniques for the same delivered tumor dose. For IMPT, neutron doses are lower than non-neutron doses close to the target but become larger than non-neutron doses further away from the target. Results of WG9 studies have provided out-of-field dose levels required for an extensive set of radiotherapy techniques, including proton therapy, and involving a complete description of organ doses of pediatric patients. Such studies are needed for validating mathematical models and Monte Carlo simulation tools for out-of-field dosimetry which is essential for dedicated epidemiological studies which evaluate the risk of second cancers and other late effects for pediatric patients treated with radiotherapy

El uso de youtube para enseñar el equilibrio macroeconómico.

La comprensión y retención del conocimiento por parte de los estudiantes requiere hoy en día la integración de las tecnologías en el proceso educativo. Los modelos macroeconómicos constituyen una herramienta básica para que los profesores describan el funcionamiento de una economía, así como para analizar los impactos de las políticas públicas en las variables macroeconómicas. En el caso de la macroeconomía introductoria e intermedia, la enseñanza se lleva a cabo básicamente mediante análisis gráficos concatenados que representan los mercados y los procesos dinámicos involucrados en el cambio de un equilibrio a otro. Sin embargo, los estudiantes de la Facultad de Ciencias Económicas y Empresariales de la Universidad de Sevilla muestran dificultades para entender y conservar tanto las representaciones gráficas, como para involucrarse en el pensamiento prospectivo (es decir, los cambios concatenados en las variables macroeconómicas). Una posible explicación se puede encontrar en la naturaleza estática de los materiales de aprendizaje (básicamente, libros y notas del alumno tomadas durante las clases). En este sentido, el ofrecimiento de videos dinámicos a los estudiantes como material de complemento podría ayudar a mejorar la comprensión de los estudiantes y, por lo tanto, el rendimiento académico. Estos videos mostrarían los análisis gráficos y los procesos involucrados, estando disponibles en plataformas públicas de difusión como YouTube. Este documento presenta los resultados de un cuestionario hecho a 131 estudiantes de macroeconomía introductoria con respecto a su uso de videos de YouTube como material de aprendizaje. Los resultados muestran que el 48% de los estudiantes entrevistados ven videos de YouTube con fines de aprendizaje, disminuyendo al 19% cuando se refiere a temas relacionados con Economía. Sin embargo, más del 80% afirma que estaría dispuesto a ver videos de YouTube para aprender Macroeconomía. Además, los estudiantes indican que si el video es interesante y útil, su duración no determina su disposición a verlo. Finalmente, y con respecto a las posibles diferencias en las características personales de los estudiantes (por ejemplo, género, edad, factores socioeconómicos, asistencia de clase, motivación y calificaciones previas) entre diferentes perfiles de estudiantes (por ejemplo, los espectadores actuales de videos de YouTube como material de aprendizaje o no), se han encontrado diferencias.Student’s comprehension and retention of knowledge requires nowadays the integration of technologies in the educational process. Macroeconomic models constitute a basic tool for lecturers at describing the functioning of an economy, as well as to analyse the impacts of public policies in macroeconomic variables. In the case of introductory and intermediate macroeconomics, teaching is basically carried out by using concatenated graphical analyses that represent the involved markets and the dynamic processes involved in moving from one equilibrium to another. However, students of the Faculty of Economics and Business at the University of Seville show difficulties at understanding and retaining both graphical representations, as well as at engaging in forward-looking thinking (i.e. the concatenated changes in macroeconomic variables). A possible explanation may be found on the static nature of learning materials (basically, books and student’s notes taken during lectures). In this regard, offering dynamic videos to the students as complement material could help to improve students’ understanding and thereby, academic performance. These videos would show the graphical analyses and the processes involved, being available at public diffusion platforms such as YouTube. This paper presents the results of a questionnaire made to 131 students of introductory macroeconomics regarding their use of YouTube videos as learning material. Results show that 48% of interviewed students view YouTube videos for learning purposes, decreasing to 19% when it refers to subjects related to Economics. Nevertheless, more than 80% affirm that they would be willing to view YouTube videos to learn Macroeconomics. Additionally, students indicate that if the video is interesting and helpful, its length does not determine their willingness to view it. Finally, and regarding potential differences in students’ personal characteristics (e.g. gender, age, socio-economic factors, class assistance, motivation and previous qualifications) between different student profiles (e.g. current viewers of YouTube videos as learning material or not), no significant differences have been found

Peripheral organ equivalent dose estimation procedure in proton therapy

The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in representative locations inside an anthropomorphic phantom where photon and neutron dosimeters were inserted. The Monte Carlo simulation was needed for obtaining neutron energy distribution inside the phantom. The methodology was implemented for a head irradiation case in the passive proton beam of iThemba Labs (South Africa). Thermoluminescent dosimeter (TLD)-600 and TLD-700 pairs were used as dosimeters inside the phantom and GEANT code for simulations. In addition, Bonner sphere spectrometry was performed inside the treatment room to obtain the neutron spectra, some relevant neutron dosimetric quantities per treatment Gy, and a percentual distribution of neutron fluence and ambient dose equivalent in four energy groups, at two locations. The neutron spectrum at one of those locations was also simulated so that a reasonable agreement between simulation and measurement allowed a validation of the simulation. Results showed that the total out-of-field dose equivalent inside the phantom ranged from 1.4 to 0.28 mSv/Gy, mainly due to the neutron contribution and with a small contribution from photons, 10% on average. The order of magnitude of the equivalent dose in organs was similar, displaying a slow reduction in values as the organ is farther from the target volume. These values were in agreement with those found by other authors in other passive beam facilities under similar irradiation and measurement conditions

Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study

Background & aim: A diet quality index (DQI) is a tool that provides an overall score of an individual''s dietary intake when assessing compliance with food-based dietary guidelines. A number of DQIs have emerged, albeit their associations with health-related outcomes are debated. The aim of the present study was to assess whether adherence to dietary intervention, and the overall quality of the diet, can predict body composition changes. Methods: To this purpose, overweight/obese adolescents (n = 117, aged: 13–16 years; 51 males, 66 females) were recruited into a multi-component (diet, physical activity and psychological support) family-based group treatment programme. We measured the adolescents’ compliance and body composition at baseline and after 2 months (intensive phase) and 13 months (extensive phase) of follow-up. Also, at baseline, after 6 months, and at the end of follow-up we calculated the DQI. Results: Global compliance with the dietary intervention was 37.4% during the intensive phase, and 14.3% during the extensive phase. Physical activity compliance was 94.1% at 2-months and 34.7% at 13months and psychological support compliance were growing over the intervention period (10.3% intensive phase and 45.3% during extensive phase). Adolescents complying with the meal frequency criteria at the end of the extensive phase had greater reductions in FMI z-scores than those did not complying (Cohen''s d = 0.53). A statistically significant association was observed with the diet quality index. DQI-A variation explained 98.1% of BMI z-score changes and 95.1% of FMI changes. Conclusions: We conclude that assessment of changes in diet quality could be a useful tool in predicting body composition changes in obese adolescents involved in a diet and physical activity intervention programme backed-up by psychological and family support

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND: Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVE: We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS: We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited from 29 international centers. RESULTS: At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% ± 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of ≤35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS: MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with &gt;80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation