Rincón Didáctico de Orientación y Atención a la Diversidad. Consejería de Educación. Junta de Extremadura

El Rincón Didáctico de Orientación y Atención a la Diversidad de la Consejería de Educación de la Junta de Extremadura es una web que pre tende ser un lugar de encuentro para los profesionales de la atención a la diversidad. La escasez de recursos interactivos que funcionen bajo sistemas operativos no propietarios unido a la ingente cantidad de información exis tente en la web sobre atención a la diversidad, exigía un lugar específico que aglutinase estos servicios. El Rincón busca mostrar por un lado, la in formación relevante en materia de discapacidad, y por otro, reunir recursos y servicios de calidad para profesionales y padres relacionados con el mun do de la discapacidad

A framework to centre justice in energy transition innovations

The important role of justice in energy transition technologies has been a topic of increasing interest in recent years. However, key questions remain about how inequities influence energy transition innovations (ETIs) from their design to their widespread use, which ETIs receive more funding, and who controls ETI research, prototyping and deployment. Here we propose a framework to centre justice in energy transition innovations (CJI) and examine how three tenets of justice (recognition, procedural and distributional justice) influence each level of ETI, including niche, regime and landscape levels. We examine wind energy in Mexico and multiple ETIs in Los Angeles as use cases to show how our CJI framework can help reveal the specific inequities undermining just energy transitions at crucial analytical levels of ETI in practice. Our CJI framework offers a path for promoters, practitioners and underserved communities to target the problems these groups face and create ETIs that better address their specific aspirations, needs and circumstances

Late Holocene archaeobotanical evolution of the Canale di Imbocco (Roman imperial port of Portus, Central Italy)

The Roman port of Portus was the most important in the Mediterranean during the imperial period (27 BC–476 AD). It wasmade up of an outer port or Claudius basin and an inner hexagon or Trajan's port, joined by the Canale di Imbocco. The archaeobotanical record obtained in a continuos sediment core taken in this channel ismade up of 19 types of plant macroremains, with a predominance of fibers of the seagrass Posidonia oceanica L., replaced by fluvial sediments in the upper part of the core. Seeds, fruits and thorns of aquatic species frommarine or brackish waters, halophyte species, edible species, freshwater riparian vegetation and remains of charcoal and wood also appear regularly. According to the inferred palaeoenviromental evolution of this core, Portus was an area of fluvial-marine interaction during the Roman Empire, with brackish water conditions interrupted by stormy periods deduced from the record of P. oceanica. The archaeobotanical and sedimentary evolution points to a restriction of marine contributions and a final implantation of a fluvial environment. In this evolution, a specific interval with abundant charcoal and caryopses of Triticum could correspond to a fire, which was followed by a possible period of greater construction activity linked with large fragments of wood.This paper was jointly supported by the following projects: a) project DGYCIT CTM2006-06722/MAR; b) DGYCIT project CGL2006-01412; c) “From the Atlantic to the Mediterranean (DEATLANTIR): Research in the infrastructures of Portus-Ostia Antica: the Lanterna wharf” (Programme of Archeology Projects Abroad, Ministry of Culture and Sports); d) From the Atlantic to the Tyrrhenian. Hispanic ports and their commercial relations with Ostia Antica (DEATLANTIR II - HAR2017-89154-P - (National R&D Plan)); and e) FEDER project 2014-2020 UHU-1260298. Other funds come from the research groups HUM-132, RNM-238 and RNM-293 (P.A.I.D.I). It is a contribution to the Center for Research in Historical, Cultural and Natural Heritage of the University of Huelva. The archaeobotanical record is deposited in the Laboratory of Paleontology and Applied Ecology of the University of Huelva

Evolución paleoambiental de una turbera finiholocena en el sector suroccidental del Parque Nacional de Doñana (S.O. España)

El análisis multidisciplinar de un perfil descubierto por las tormentas invernales en el litoral del Parque Nacional de Doñana ha permitido reconstruir la evolución de su sector occidental durante el Holoceno superior. Se han definido 3 fases que reflejan el paso desde una marisma de aguas salobres (FA-1) a una laguna de aguas dulces transformada en turbera (FA-2), para finalizar con el depósito de cordones dunares (FA-3).The multidisciplinary analysis of a profile discovered by the winter storms on the coast of the Doñana National Park has allowed us to reconstruct the evolution of its western sector during the Late Holocene. Three phases have been defined, which reflect the transition from a brackish water marsh (FA-1) to a freshwater lagoon transformed into peat bog (FA-2), to end with the deposit of dune systems (FA-3)

Transmitted drug resistance to antiretroviral drugs in Spain during the period 2019–2021

To evaluate the prevalence of transmitted drug resistance (TDR) to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI, NNRTI), protease inhibitors (PI), and integrase strand transfer inhibitors (INSTI) in Spain during the period 2019-2021, as well as to evaluate transmitted clinically relevant resistance (TCRR) to antiretroviral drugs. Reverse transcriptase (RT), protease (Pro), and Integrase (IN) sequences from 1824 PLWH (people living with HIV) were studied. To evaluate TDR we investigated the prevalence of surveillance drug resistance mutations (SDRM). To evaluate TCRR (any resistance level >= 3), and for HIV subtyping we used the Stanford v.9.4.1 HIVDB Algorithm and an in-depth phylogenetic analysis. The prevalence of NRTI SDRMs was 3.8% (95% CI, 2.8%-4.6%), 6.1% (95% CI, 5.0%-7.3%) for NNRTI, 0.9% (95% CI, 0.5%-1.4%) for PI, and 0.2% (95% CI, 0.0%-0.9%) for INSTI. The prevalence of TCRR to NRTI was 2.1% (95% CI, 1.5%-2.9%), 11.8% for NNRTI, (95% CI, 10.3%-13.5%), 0.2% (95% CI, 0.1%-0.6%) for PI, and 2.5% (95% CI, 1.5%-4.1%) for INSTI. Most of the patients were infected by subtype B (79.8%), while the majority of non-Bs were CRF02_AG (n = 109, 6%). The prevalence of INSTI and PI resistance in Spain during the period 2019-2021 is low, while NRTI resistance is moderate, and NNRTI resistance is the highest. Our results support the use of integrase inhibitors as first-line treatment in Spain. Our findings highlight the importance of ongoing surveillance of TDR to antiretroviral drugs in PLWH particularly with regard to first-line antiretroviral therapy

High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4

[Abstract] Background and Aims. Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real‐world clinical practice, showed high rates of sustained virological response (SVR) in non‐cirrhotic genotype (GT)‐1 and GT‐4 patients. These results were slightly lower in cirrhotic patients. We investigated real‐life effectiveness and safety of SOF/SMV with or without ribavirin (RBV) in a large cohort of cirrhotic patients. Methods. This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV‐GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January‐2014 and December‐2015. Demographic, clinical, virological and safety data were analysed. Results. Overall SVR was 92.3%; the majority of patients were treated with RBV (62%) for 12 weeks (92.4%). No significant differences in SVR were observed between genotypes (GT1a:94.3%; GT1b:91.7%; GT4:91.1%). Those patients with more advanced liver disease (Child B/C, MELD≥10) or portal hypertension (platelet count≤100×109/L, transient elastography≥21 Kpa) showed significantly lower SVR rates (84.4%‐91.9%) than patients with less advanced liver disease (93.8%‐95.9%, P<.01 in all cases). In the multivariate analysis, the use of RBV, female gender, baseline albumin≥35 g/L, MELD<10 and lack of exposure to a triple therapy regimen were independent predictors of SVR (P<.05). Serious adverse events (SAEs) and SAE‐associated discontinuation events occurred in 5.9% and 2.6%. Conclusions. In this large cohort of cirrhotic patients managed in the real‐world setting in Spain, SOF/SMV±RBV yielded to excellent SVR rates, especially in patients with compensated liver cirrhosis. In addition, this combination showed to be safe, with low rates of SAEs and early discontinuations.Instituto de Salud Carlos III; PI15/0015

Respiratory and mental health effects of wildfires: an ecological study in Galician municipalities (north-west Spain)

<p>Abstract</p> <p>Background</p> <p>During the summer of 2006, a wave of wildfires struck Galicia (north-west Spain), giving rise to a disaster situation in which a great deal of the territory was destroyed. Unlike other occasions, the wildfires in this case also threatened farms, houses and even human lives, with the result that the perception of disaster and helplessness was the most acute experienced in recent years. This study sought to analyse the respiratory and mental health effects of the August-2006 fires, using consumption of anxiolytics-hypnotics and drugs for obstructive airway diseases as indicators.</p> <p>Methods</p> <p>We conducted an analytical, ecological geographical- and temporal-cluster study, using municipality-month as the study unit. The independent variable was exposure to wildfires in August 2006, with municipalities thus being classified into the following three categories: no exposure; medium exposure; and high exposure. Dependent variables were: (1) anxiolytics-hypnotics; and (2) drugs for obstructive airway diseases consumption. These variables were calculated for the two 12-month periods before and after August 2006. Additive models for time series were used for statistical analysis purposes.</p> <p>Results</p> <p>The results revealed a higher consumption of drugs for obstructive airway diseases among pensioners during the months following the wildfires, in municipalities affected versus those unaffected by fire. In terms of consumption of anxiolytics-hypnotics, the results showed a significant increase among men among men overall -pensioners and non-pensioners- in fire-affected municipalities.</p> <p>Conclusions</p> <p>Our study indicates that wildfires have a significant effect on population health. The coherence of these results suggests that drug utilisation research is a useful tool for studying morbidity associated with environmental incidents.</p

Resultados Semilleros de Investigación 2009-2010

La publicación recoge los doce informes finales de investigación presentados por los estudiantes de ocho Semilleros 1 y cuatro Semilleros 2, correspondientes a la convocatoria 2009–2010 y se constituye en el Número 25 de la Serie de Investigaciones en Construcción, si bien este es el primer Número publicado en formato digital que UNIJUS se permite poner a disposición no sólo de la comunidad universitaria, sino también de la sociedad colombiana e internacional, interesada en los temas estudiados por los jóvenes investigadores de la Facultad de Derecho, Ciencias Políticas y Sociales de la Universidad Nacional de Colombia

Gyrogonites of carophytes in the Doñana National Park: Their record in Pleistocene and Holocene sediments

Las caráceas constituyen un grupo importante de macrófitos acuáticos en el Parque Nacional de Doñana. En este artículo, se estudia la distribución de sus girogonitos en diversos medios de este espacio protegido (lagunas temporales, surgencias, caños, márgenes del río Guadalquivir, etc), relacionándola tanto con las variables físico-químicas como con la textura y mineralogía del sedimento. Se efectúa una revisión del registro geológico de este grupo en diversos testigos compuestos por sedimentos pleistocenos y holocenos.Characeans are an important group of aquatic macrophytes in the Doñana National Park. In this paper, we study the distribution of their gyrogonites in different environments of this protected area (temporary ponds, springs, streams, banks of the Guadalquivir River, etc.), relating it to both physico-chemical variables and the texture and mineralogy of the sediment. A review of the geological record of this group in different cores composed of Pleistocene and Holocene sediments is carried out.Este trabajo ha sido financiado mediante los siguientes proyectos: a) proyecto DGYCIT CTM2006-06722/MAR; b) proyecto DGYCIT CGL2006-01412; y c) proyecto CIMA UID/MAR/00350/2013 de la FCT de Portugal. Otros fondos han procedido de los grupos de investigación RNM-238, RNM-293 and RNM-349 del P.A.I.D.I. de la Junta de Andalucía. Es una contribución al Centro de Investigación en Patrimonio Histórico, Cultural y Natural (CIPHCN) de la Universidad de Huelva. Los autores quieren agradecer las aportaciones de dos revisores anónimos y del secretario de redacción Dr. Jaime Ordóñez, que han contribuido a la mejora sustancial del manuscrito original.Departamento de Geodinámica y Paleontologí