4,402 research outputs found
Apparent and actual galaxy cluster temperatures
The redshift evolution of the galaxy cluster temperature function is a
powerful probe of cosmology. However, its determination requires the
measurement of redshifts for all clusters in a catalogue, which is likely to
prove challenging for large catalogues expected from XMM--Newton, which may
contain of order 2000 clusters with measurable temperatures distributed around
the sky. In this paper we study the apparent cluster temperature, which can be
obtained without cluster redshifts. We show that the apparent temperature
function itself is of limited use in constraining cosmology, and so concentrate
our focus on studying how apparent temperatures can be combined with other
X-ray information to constrain the redshift. We also briefly study the
circumstances in which non-thermal spectral features can give redshift
information.Comment: 7 pages LaTeX file with 13 figures incorporated (uses mn.sty and
epsf). Minor changes to match MNRAS accepted versio
Pairing symmetry of the one-band Hubbard model in the paramagnetic weak-coupling limit: a numerical RPA study
We study the spin-fluctuation-mediated superconducting pairing gap in a
weak-coupling approach to the Hubbard model for a two dimensional square
lattice in the paramagnetic state. Performing a comprehensive theoretical study
of the phase diagram as a function of filling, we find that the superconducting
gap exhibits transitions from p-wave at very low electron fillings to
d_{x^2-y^2}-wave symmetry close to half filling in agreement with previous
reports. At intermediate filling levels, different gap symmetries appear as a
consequence of the changes in the Fermi surface topology and the associated
structure of the spin susceptibility. In particular, the vicinity of a van Hove
singularity in the electronic structure close to the Fermi level has important
consequences for the gap structure in favoring the otherwise sub-dominant
triplet solution over the singlet d-wave solution. By solving the full gap
equation, we find that the energetically favorable triplet solutions are chiral
and break time reversal symmetry. Finally, we also calculate the detailed
angular gap structure of the quasi-particle spectrum, and show how
spin-fluctuation-mediated pairing leads to significant deviations from the
first harmonics both in the singlet d_{x^2-y^2} gap as well as the chiral
triplet gap solution.Comment: 11 pages 11 figure
Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway
Molecular conjugate vectors may be constructed that accomplish high efficiency gene transfer by the receptor-mediated endocytosis pathway. In order to mediate escape from lysosomal degradation, we have incorporated adenoviruses into the functional design of the conjugate. In doing so, however, we have introduced an additional ligand, which can bind to receptors on the cell surface, undermining the potential for cell specific targeting. To overcome this, we have treated the adenovirus with a monoclonal anti-fiber antibody, which renders the virus incapable of binding to its receptor. The result is a multi-functional molecular conjugate vector, which has preserved its binding specificity while at the same time being capable of preventing lysosomal degradation of endosome-internalized conjugate-DNA complexes. This finding indicates that adenoviral binding is not a prerequisite for adenoviral-mediated endosome disruption
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema
A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise. Pulmonary function testing revealed a normal forced vital capacity (FVC, 98.1% predicted) and diffusion capacity for carbon monoxide (D(L(CO)), 91.2% predicted), but significant airway obstruction at rest [forced expiratory volume in 1 sec (FEV(1)), 66.5% predicted; forced expiratory flow at 50% of vital capacity (FEF(50)), 34.3% predicted; and FEV(1) /FVC 56.5%] that was not reversible with an inhaled bronchodilator. Gas exchange worsened from rest to exercise, with the alveolar to arterial P(O2) difference (AaD(O2)) increasing from 0 at rest to 41 mmHg at maximal normoxic exercise (VO(2) = 41.4 mL/kg/min) and from 11 to 31 mmHg at maximal hypoxic exercise (VO(2) = 21.9 mL/kg/min). Arterial P(O2) decreased to 67.8 and 29.9 mmHg at maximal normoxic and hypoxic exercise, respectively. These data indicate that our subject with a history of BPD is prone to a greater degree of exercise-induced arterial hypoxemia for a given VO(2) and F(I(O2)) than healthy age-matched controls, which may increase the subject's susceptibility to high altitude illness
Anatomy, morphology and evolution of the patella in squamate lizards and tuatara (Sphenodon punctatus)
The patella (kneecap) is the largest and best-known of the sesamoid bones, postulated to confer biomechanical advantages including increasing joint leverage and reinforcing the tendon against compression. It has evolved several times independently in amniotes, but despite apparently widespread occurrence in lizards, the patella remains poorly characterised in this group and is, as yet, completely undescribed in their nearest extant relative Sphenodon (Rhynchocephalia). Through radiography, osteological and fossil studies we examined patellar presence in diverse lizard and lepidosauromorph taxa, and using computed tomography, dissection and histology we investigated in greater depth the anatomy and morphology of the patella in 16 lizard species and 19 Sphenodon specimens. We have found the first unambiguous evidence of a mineralised patella in Sphenodon, which appears similar to the patella of lizards and shares several gross and microscopic anatomical features. Although there may be a common mature morphology, the squamate patella exhibits a great deal of variability in development (whether from a cartilage anlage or not, and in the number of mineralised centres) and composition (bone, mineralised cartilage or fibrotendinous tissue). Unlike in mammals and birds, the patella in certain lizards and Sphenodon appears to be a polymorphic trait. We have also explored the evolution of the patella through ancestral state reconstruction, finding that the patella is ancestral for lizards and possibly Lepidosauria as a whole. Clear evidence of the patella in rhynchocephalian or stem lepidosaurian fossil taxa would clarify the evolutionary origin(s) of the patella, but due to the small size of this bone and the opportunity for degradation or loss we could not definitively conclude presence or absence in the fossils examined. The pattern of evolution in lepidosaurs is unclear but our data suggest that the emergence of this sesamoid may be related to the evolution of secondary ossification centres and/or changes in knee joint conformation, where enhancement of extensor muscle leverage would be more beneficial.Sophie Regnault, Marc E. H. Jones, Andrew A. Pitsillides, John R. Hutchinso
A COMPARISON OF PEDALING MECHANICS IN EXPERIENCED POSE AND TRADITIONAL CYCLISTS
The purpose of this study was to describe the mechanical differences between two experienced male Pose cyclists and traditional cyclists. Pose cycling requires a specific set-up that attempts to place the centre of mass over the pedal to increase the non-muscular force/power component during the downstroke. Results revealed that for the Pose cyclists the centre of mass was closer to vertically above the pedal when in the horizontal forward position. Non-muscular contributions to pedal power tended to be greater in the Pose cyclists compared to the traditional cyclists. In addition, we found joint differences in the power contribution to pedal power in the traditional cyclists who relied more heavily on contributions from the muscles spanning the knee joint, whereas Pose cyclists had greater ankle and hip power contributions
Effect of abdominal binding on respiratory mechanics during exercise in athletes with cervical spinal cord injury
West CR, Goosey-Tolfrey VL, Campbell IG, Romer LM. Effect of
abdominal binding on respiratory mechanics during exercise in athletes
with cervical spinal cord injury. J Appl Physiol 117: 36â45, 2014. First
published May 22, 2014; doi:10.1152/japplphysiol.00218.2014.âWe
asked whether elastic binding of the abdomen influences respiratory
mechanics during wheelchair propulsion in athletes with cervical
spinal cord injury (SCI). Eight Paralympic wheelchair rugby players
with motor-complete SCI (C5-C7) performed submaximal and maximal
incremental exercise tests on a treadmill, both with and without
abdominal binding. Measurements included pulmonary function,
pressure-derived indices of respiratory mechanics, operating lung
volumes, tidal flow-volume data, gas exchange, blood lactate, and
symptoms. Residual volume and functional residual capacity were
reduced with binding (77 18 and 81 11% of unbound, P 0.05),
vital capacity was increased (114 9%, P 0.05), whereas total lung
capacity was relatively well preserved (99 5%). During exercise,
binding introduced a passive increase in transdiaphragmatic pressure,
due primarily to an increase in gastric pressure. Active pressures
during inspiration were similar across conditions. A sudden, sustained
rise in operating lung volumes was evident in the unbound condition,
and these volumes were shifted downward with binding.
Expiratory flow limitation did not occur in any subject and there
was substantial reserve to increase flow and volume in both
conditions. V Ë O2 was elevated with binding during the final stages
of exercise (8 â12%, P 0.05), whereas blood lactate concentration
was reduced (16 â19%, P 0.05). V Ë O2/heart rate slopes were
less steep with binding (62 35 vs. 47 24 ml/beat, P 0.05).
Ventilation, symptoms, and work rates were similar across conditions.
The results suggest that abdominal binding shifts tidal
breathing to lower lung volumes without influencing flow limitation,
symptoms, or exercise tolerance. Changes in respiratory
mechanics with binding may benefit O2 transport capacity by an
improvement in central circulatory function.This article has been made available through the Brunel Open Access Publishing Fund
The accessory spleen: prevalence and imaging findings in 1735 consecutuve patients examined by multidetector CT
'Objective: 'To analyze the prevalence and CT findings of accessory spleens in the normal population. 'Material and methods: 'CT-examinations of 1735 consecutive patients, all examined by triple phase 16-row multidetector computed tomography (MDCT) of the abdomen, were retrospectively analyzed with special emphasis on the presence, location and imaging aspects of accessory spleens. 'Results: '199 patients showed an accessory spleen (11%). Size of accessory spleens ranged from 3 to 20 mm (mean 10 mm). In 60% the accessory spleen was located at the level of the splenic hilum and in 33% at the level of the lower pole. In 46% the accessory spleen was located medially and in 43% ventrally. 19 patients presented with two (1.1%) and seven patients with three accessory spleens (0.4%), respectively. One patient showed splenosis and one patient showed an enlarged accessory spleen (5 cm) secondary to a splenic apoplexy (i.e. hemorrhagic infarction) of the accessory spleen, caused by torsion. 'Conclusion: 'Accessory spleens may be identified by MDCT in about 11% of patients. Familiarity with normal imaging findings and knowledge on differential diagnoses, possible pathologies and potential pitfalls helps to differentiate from other findings in the upper abdomen
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