Zero-conductance resonances and spin-filtering effects in ring conductors subject to Rashba coupling

We investigate the effect of Rashba spin-orbit coupling and of a tunnel barrier on the zero conduc- tance resonances appearing in a one-dimensional conducting Aharonov-Bohm (AB) ring symmet- rically coupled to two leads. The transmission function of the corresponding one-electron problem is derived within the scattering matrix approach and analyzed in the complex energy plane with focus on the role of the tunnel barrier strength on the zero-pole structure characteristic of trans- mission (anti)resonances. The lifting of the real conductance zeros is related to the breaking of the spin-reversal symmetry and time-reversal symmetry of Aharonov-Casher (AC)and AB rings, as well as to rotational symmetry breaking in presence of a tunnel barrier. We show that the polarization direction of transmitted electrons can be controlled via the tunnel barrier strength and discuss a novel spin-filtering design in one-dimensional rings with tunable spin-orbit interaction.Comment: 13 pages, 8 figure

Persistent spin and charge currents and magnification effects in open ring conductors subject to Rashba coupling

We analyze the effect of Rashba spin-orbit coupling and of a local tunnel barrier on the persistent spin and charge currents in a one-dimensional conducting Aharonov-Bohm (AB) ring symmetrically coupled to two leads. First, as an important consequence of the spin-splitting, it is found that a persistent spin current can be induced which is not simply proportional to the charge current. Second, a magnification effect of the persistent spin current is shown when one tunes the Fermi energy near the Fano-type antiresonances of the total transmission coefficient governed by the tunnel barrier strength. As an unambiguous signature of spin-orbit coupling we also show the possibility to produce a persistent pure spin current at the interference zeros of the transmittance. This widens the possibilities of employing mesoscopic conducting rings in phase-coherent spintronics applications.Comment: 6 pages, 5 figures, to appear in PR

Neural networks in geophysical applications

Neural networks are increasingly popular in geophysics. Because they are universal approximators, these tools can approximate any continuous function with an arbitrary precision. Hence, they may yield important contributions to finding solutions to a variety of geophysical applications. However, knowledge of many methods and techniques recently developed to increase the performance and to facilitate the use of neural networks does not seem to be widespread in the geophysical community. Therefore, the power of these tools has not yet been explored to their full extent. In this paper, techniques are described for faster training, better overall performance, i.e., generalization,and the automatic estimation of network size and architecture

Antibody-drug conjugates (ADC) against cancer stem-like cells (CSC) - Is there still room for optimism?

Cancer stem-like cells (CSC) represent a subpopulation of tumor cells with peculiar functionalities that distinguish them from the bulk of tumor cells, most notably their tumor-initiating potential and drug resistance. Given these properties, it appears logical that CSCs have become an important target for many pharma companies. Antibody-drug conjugates (ADC) have emerged over the last decade as one of the most promising new tools for the selective ablation of tumor cells. Three ADCs have already received regulatory approval and many others are in different phases of clinical development. Not surprisingly, also a considerable number of anti-CSC ADCs have been described in the literature and some of these have entered clinical development. Several of these ADCs, however, have yielded disappointing results in clinical studies. This is similar to the results obtained with other anti-CSC drug candidates, including native antibodies, that have been investigated in the clinic. In this article we review the anti-CSC ADCs that have been described in the literature and, in the following, we discuss reasons that may underlie the failures in clinical trials that have been observed. Possible reasons relate to the biology of CSCs themselves, including their heterogeneity, the lack of strictly CSC-specific markers, and the capacity to interconvert between CSCs and non-CSCs; second, inherent limitations of some classes of cytotoxins that have been used for the construction of ADCs; third, the inadequacy of animal models in predicting efficacy in humans. We conclude suggesting some possibilities to address these limitations

Gingival hyperplasia around dental implants in jaws reconstructed with free vascularized flaps: a case report series

Free vascularized flaps are the gold standard for reconstruction of the facial skeleton after surgical ablation of pathologies or when important atrophy of the jaws exists. A frequent problem seen during prosthetic rehabilitation after reconstruction with free vascularized flaps is the onset of hyperplastic granulomatous reactive tissue around the prosthetic abutment of the implant. The features of this phenomenon seem to be directly related to the characteristics of the periimplant tissue and of the manufacturing materials of the prosthesis and abutments. This complication can be seen quite often; we found it in 7 of 40 patients (17.5%). It does not seem to significantly affect the survival rate of implants. The aim of the study was to analyze the behavior of such lesions and to suggest our clinical approach with the management of these kinds of patients and complications. To remove gingival hyperplasia, we used either a traditional cold scalpel or an electric cautery or laser. We had good results using these tools. The onset of this phenomenon was not influenced by either the kind of implant and free flaps used or by the local conditions of the patients (such as radiotherapy). The number of recurrences was highly influenced by the oral hygiene of the patients

ENFICA-FC: Design of transport aircraft powered by fuel cell & flight test of zero emission 2-seater aircraft powered by fuel cells fueled by hydrogen

Fuel cells could become the main power source for small general aviation aircraft or could replace APU and internal sub-systems on larger aircraft, to obtain all-electric or more-electric air vehicles. There are several potential advantages of using such a power source, that range from environmental and economic issues to performance and operability aspects. A preliminary design is reported. Also, the paper contains a description of testing activities related to experimental flights of an all-electric general aviation aircraft fueled by hydrogen. Great importance has been given to the testing phase of the prototype and examples of each testing stage are shown ranging from the single components to the final test flights. During the 6 experimental flights a rotation speed of 84 km/h was obtained in 184 m of taxi at power of 35 kW. Level flight was attained at 135 km/h and endurance of 39 min by mean of only a fuel cell power setting (speed world record for the FAI Sporting Code Category C - airplane

Coronary flow reserve of the angiographically normal left anterior descending coronary artery in patients with remote coronary artery disease

Coronary artery disease (CAD) has been suggested to alter coronary flow reserve (CFR; the ratio between hyperemic and baseline coronary flow velocities) not only in territories supplied by stenotic arteries but also in angiographically normal, remote regions. However, few data exist regarding the left anterior descending (LAD) coronary artery as the normal index artery. The influence of remote CAD on CFR of the angiographically normal LAD was evaluated with transthoracic Doppler ultrasound to measure CFR in the LAD during 90 seconds of venous adenosine infusion (140 microg/kg/min) in 122 subjects who were assigned to 1 group; group 1 comprised 49 controls without angiographically detectable CAD, and group 2 consisted of 73 patients with an angiographically normal LAD and remote CAD. Group 2 was divided into 4 subgroups: 16 patients with previous remote percutaneous coronary intervention (group 2A); 13 patients with significant remote stenosis (group 2B); 23 patients with previous remote myocardial infarction and percutaneous coronary intervention (group 2C); and 21 patients with previous remote myocardial infarction but no percutaneous coronary intervention (group 2D). CFR in the LAD was not significantly different in groups 1 and 2 (3.08 +/- 0.61 and 3.03 +/- 0.69, respectively, p = NS). Decreased ejection fraction and increased wall motion score index in patients with remote CAD (p < 0.00001) and multivessel CAD did not affect CFR in the LAD (group 2A 3.18 +/- 0.77; group 2B 3.05 +/- 0.65; group 2C 3.07 +/- 0.79; group 2D 2.86 +/- 0.50, respectively; F = 0.63, p = NS). In conclusion, CFR of an angiographically normal LAD is preserved in patients with remote CAD, even in the presence of previous remote myocardial infarction and wall motion abnormalities

Successful Coronary Stent Retrieval From a Pedal Artery

The purpose of this article is to report complications from a coronary drug-eluting stent lost in the peripheral circulation. We report the case of successful retrieval of a sirolimus coronary stent from a pedal artery in a young patient who underwent coronary angiography for previous anterior myocardial infarction. Recognition of stent embolization requires adequate removal of the device to avoid unwelcome clinical sequelae. Keywords Coronary stent Microsnare technique Peripheral embolization Stent retrieva

Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease

Coronary heart disease (CHD), one of the leading causes of disability and death worldwide, is a multifactorial disease whose early diagnosis is demanding. Thus, biomarkers predicting the occurrence of this pathology are of great importance from a clinical and therapeutic standpoint. By means of a pilot study on peripheral blood cells (PBMCs) of subjects with no coronary lesions (CTR; n = 2) and patients with stable CAD (CAD; n = 2), we revealed 61 differentially methylated regions (DMRs) (18 promoter regions, 24 genes and 19 CpG islands) and 14.997 differentially methylated single CpG sites (DMCs) in CAD patients. MiRNA-seq results displayed a peculiar miRNAs profile in CAD patients with 18 upregulated and 32 downregulated miRNAs (FC &gt;= +/- 1.5, p &lt;= 0.05). An integrated analysis of genome-wide DNA methylation and miRNA-seq results indicated a significant downregulation of hsa-miR-200c-3p (FCCAD = -2.97, p &lt;= 0.05) associated to the hypermethylation of two sites (genomic coordinates: chr12:7073122-7073122 and chr12:7072599-7072599) located intragenic to the miR-200c/141 genomic locus (encoding hsa-miR-200c-3p) (p-value = 0.009) in CAD patients. We extended the hsa-miR-200c-3p expression study in a larger cohort (CAD = 72, CTR = 24), confirming its reduced expression level in CAD patients (FCCAD = -2; p = 0.02). However, when we analyzed the methylation status of the two CpG sites in the same cohort, we failed to identify significant differences. A ROC curve analysis showed good performance of hsa-miR-200c-3p expression level (AUC = 0.65; p = 0.02) in distinguishing CAD from CTR. Moreover, we found a significant positive correlation between hsa-miR-200c-3p expression and creatinine clearance (R-2 = 0.212, p &lt; 0.005, Pearson r = 0.461) in CAD patients. Finally, a phenotypic correlation performed in the CAD group revealed lower hsa-miR-200c-3p expression levels in CAD patients affected by dyslipidemia (+DLP, n = 58) (p &lt; 0.01). These results indicate hsa-miR-200c-3p as potential epi-biomarker for the diagnosis and clinical progression of CAD and highlight the importance of deeper studies on the expression of this miRNA to understand its functional role in coronary artery disease development

The Formation of a Realistic Disk Galaxy in Lambda Dominated Cosmologies

We simulate the formation of a realistic disk galaxy within the hierarchical scenario of structure formation and study its internal properties to the present epoch. We compare results from a LambdaCDM simulation with a LambdaWDM (2keV) simulation that forms significantly less small scale structure. We show how high mass and force resolution in both the gas and dark matter components play an important role in solving the angular momentum catastrophe claimed from previous simulations of galaxy formation within the hierarchical framework. The stellar material in the disk component has a final specific angular momentum equal to 40% and 90% of that of the dark halo in the LambdaCDM and LambdaWDM models respectively. The LambdaWDM galaxy has a drastically reduced satellite population and a negligible stellar spheroidal component. Encounters with satellites play only a minor role in disturbing the disk. Satellites possess a variety of star formation histories linked to mergers and pericentric passages along their orbit around the primary galaxy. In both cosmologies, the galactic halo retains most of the baryons accreted and builds up a hot gas phase with a substantial X-ray emission. Therefore, while we have been successful in creating a realistic stellar disk in a massive galaxy within the LambdaCDM scenario, energy injection emerges as necessary ingredient to reduce the baryon fraction in galactic halos, independent of the cosmology adopted. (abridged)Comment: ApJ in press. Images and movies at http://hpcc.astro.washington.edu/faculty/fabio/galform.html Significantly expanded revised version. (9 pages vs the original 4