Dictators and their Puppets: Musicians who advocated for musical integrity in twentieth-century regimes

Thesis (D.M.A.)--University of Washington, 2018In the ruthless dictatorships of the Twentieth Century, specifically Hitler’s Germany, Stalin’s USSR, and Mao’s China, musicians maintained a high degree of social and political influence. From a musical standpoint, interaction between despots and musicians had a profound impact on the quality and quantity of music created during these eras. What do societies owe musicians in order to facilitate their creative output, and, in return, what do musicians owe society as artists? Personal accounts from Winifred Wagner, Wilhelm Furtwängler, Arnold Schoenberg, Dmitry Shostakovich, Yin Chengzong, and those who knew them, exhibit direct interactions between dictators and musicians. This focus on specific relationships demonstrates the extent of political control. Although viewing these regimes’ atrocities as bygone history is convenient, oppressive governments continue to blight humanity today, and musicians have a unique ability to respond

UW School of Music presents a Voice Division Recital February 27, 2017

Concert ProgramConcert Program for UW School of Music presents a Voice Division Recital February 27, 201

Brechemin Piano Series November 10, 2016

Concert ProgramBrechemin Piano Series November 10, 201

Brechemin Piano Series May 28, 2015

Concert ProgramBrechemin Piano Series May 28, 201

Brechemin Piano Series December 1, 2016

Concert ProgramBrechemin Piano Series December 1, 201

Opera Workshop: Mozart Scenes January 14, 2017

Concert ProgramConcert Program for Opera Workshop: Mozart Scenes January 14, 201

Schubertiade! Showcasing works by the great composer Franz Schubert (1797-1828) with Robin McCabe, host Part II March 6, 2016

Concert ProgramSchubertiade! Showcasing works by the great composer Franz Schubert (1797-1828) with Robin McCabe, host Part II March 6, 201

Intersections Music, Words, and Pictures Robin MCCabe, host March 4, 2018

Concert ProgramConcert Program for Intersections Music, Words, and Pictures Robin McCabe, host March 4, 201

Opera Workshop Works in Process December 2, 2017

Concert ProgramConcert Program for Opera Workshop Works in Process December 2, 201

Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry

Lysine residues undergo diverse and reversible post-translational modifications (PTMs). Lysine acetylation has traditionally been studied in the epigenetic regulation of nucleosomal histones that provides an important mechanism for regulating gene expression. Histone acetylation plays a key role in cardiac remodeling and function. However, recent studies have shown that thousands of proteins can be acetylated at multiple acetylation sites, suggesting the acetylome rivals the kinome as a PTM. Based on this, we examined the impact of obesity on protein lysine acetylation in the left ventricle (LV) of male c57BL/6J mice. We reported that obesity significantly increased heart enlargement and fibrosis. Moreover, immunoblot analysis demonstrated that lysine acetylation was markedly altered with obesity and that this phenomenon was cardiac tissue specific. Mass spectral analysis identified 2515 proteins, of which 65 were significantly impacted by obesity. Ingenuity Pathway Analysis (R) (IPA) further demonstrated that these proteins were involved in metabolic dysfunction and cardiac remodeling. In addition to total protein, 189 proteins were acetylated, 14 of which were significantly impacted by obesity. IPA identified the Cardiovascular Disease Pathway as significantly regulated by obesity. This network included aconitate hydratase 2 (ACO2), and dihydrolipoyl dehydrogenase (DLD), in which acetylation was significantly increased by obesity. These proteins are known to regulate cardiac function yet, the impact for ACO2 and DLD acetylation remains unclear. Combined, these findings suggest a critical role for cardiac acetylation in obesity-mediated remodeling this has the potential to elucidate novel targets that regulate cardiac pathology.this has the potential to elucidate novel targets that regulate cardiac pathology