Metamorfosi del Virtuoso. Studi sulla cultura inglese del XVII secolo (1603-1676)

Lavoro basato sull'individuazione di un profilo intellettuale della tipologia del Virtuoso nell'Inghilterra del Seicento. Contiene uno studio lessicografico del termine ed una ricostruzione delle sue origini ed uso. Propone esempi di questa tipologia attraverso studi (a carattere biografico) su Sir Kenelm Digby e John Greaves. Indaga un ruolo del Virtuoso nella costituzione della Royal Society, analizzando alcuni dei dibattiti scientifici sorti durante la Restaurazione. Prende in esame la critica all'indagine scientifica formulata da Henry Stubbe e gli elementi che portano al tramonto della "credibilità scientifica" del Virtuoso

Physiology and Pathology of Mitochondrial Dehydrogenases

Effective mitochondria bioenergetics requires the proper functioning of various intra-organelle dehydrogenases. By providing pyridine and flavin adenine dinucleotides to the electron chain, or Acyl-CoA for the reactions of the tris-carboxylic acid cycle, or the acylation of fatty acids to undergo β-oxidation, these dehydrogenases preside to the organelle production of ATP, required for a variety of cellular functions under physiological conditions. The operation of the various dehydrogenases is mainly regulated by hormones through changes in intra-mitochondrial cation levels and ratios, namely Ca2+ and Mg2+. Dysregulation of specific dehydrogenases under pathological conditions results in marked changes in the energetic level of the organelle and ultimately the cell. The present review will attempt to highlight the role of the main mitochondrial dehydrogenases and their regulation, and provide a general assessment of their dysfunction and associated consequences under some of the most common human pathologies

Thermal signatures of human pheromones in sexual and reproductive behaviour

Chemically mediated sexual communication in humans has been largely neglected due to its non-conscious and relatively concealed nature. However, menstrual cycle synchronisation, puberty onset in young pre-pubertal girls exposed to their stepfather, and consanguinity avoidance suggest a function in the physiological regulation of sexual and reproductive behaviour in humans. These phenomena are related to activation of the limbic system by pheromones. On the basis of sexually dimorphic activation of brain hypothalamic areas and the control of body temperature via the hypothalamus, our hypothesis is that human sexual pheromones can induce thermal effects that can be revealed by high-resolution thermal infrared imaging. Here we show that in women, male sexual pheromones induce thermal effects that are linked to the ovarian cycle. These findings suggest a dramatic influence of pheromones on human sexual and reproductive behaviour through neuroendocrine brain control, established on the plesiomorphic nature of chemical communication across species

Magnesium and other biometals in oxidative medicine and redox biology

No abstract available

A aliança obreira-estudantil a partir da sociabilidade educativa e do bairro em Córdoba (1955-1969)

In this article I analyze the worker-student alliance in the city of Córdoba, Argentina, during the sixties. I argue that the closeness between workers and students was not only built and deployed through their political and union ties. Since the working class was not isolated from the students and the community, their union also had a substantive articulation in everyday life, through innovative educational experiences, family and neighborhood ties that enabled a common sociability. With that idea, I explore the participation of workers in those experiences that were part of the social transformation processes that began in the ‘50s and that I understand as facilitators of additional connections with students.En este artículo analizo la alianza obrero-estudiantil en la ciudad Córdoba, Argentina, durante la década del sesenta. Argumento que el acercamiento entre obreros y estudiantes no solo se construyó y desplegó mediante sus vínculos políticos y sindicales. Debido a que la clase obrera no estaba aislada con respecto a los estudiantes y a la comunidad, su unión también tuvo una articulación sustantiva en lo cotidiano, que se evidenció en novedosas experiencias educativas y lazos familiares y vecinales que habilitaron una sociabilidad común. Con esa idea, exploro la participación de los obreros en esas experiencias que fueron parte de los procesos de transformación social abiertos a partir de los años cincuenta y que entiendo como facilitadores de conexiones adicionales con los estudiantes.Neste artigo analiso a aliança obreira-estudantil na cidade de Córdoba, Argentina, durante a década de sessenta.  Argumento que a aproximação entre os obreiros e estudantis não só se construiu a través dos vínculos políticos e sindicais, mas também pelo seu relacionamento cotidiano já que a classe obreira não estava isolada em relação aos estudantes e à comunidade. Esta união evidenciou-se em novedosa experiências educativas e laços familiares e de vizinhança que habilitaram uma sociabilidade em comum. Com esta ideia, exploro a participação dos obreiros nessas experiências que foram parte dos processos de transformação social abertos a partir dos anos cinquenta e que os considero como facilitadores de conexões adicionais com os estudantes

Host defense pathways against fungi : the basis for vaccines and immunotherapy

Fungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understanding of the complex host–pathogen interactions and immune responses. Overcoming these challenges is expected to contribute to improved vaccination strategies aimed at personalized efficacy across distinct target patient populations. This likely requires the integration of multifaceted approaches encompassing advanced immunology, systems biology, immunogenetics, and bioinformatics in the fields of fungal and host biology and their reciprocal interactions.The studies were supported by the Specific Targeted Research Project “ALLFUN” (FP7-HEALTH-2009-260338) and the Fondazione per la Ricerca sulla Fibrosi Cistica (FFC#21/2010, with the contribution of Francesca Guadagnin, Coca Cola Light® Tribute to Fashion and Delegazione FFC di Belluno). Agostinho Carvalho and Cristina Cunha were financially supported by fellowships from Fundação para a Ciência e Tecnologia, Portugal (contracts SFRH/BPD/46292/2008 and SFRH/BD/65962/2009, respectively)

Factores relacionados al abandono del método anticonceptivo hormonal en mujeres en un Centro de Salud Huancayo 2022

El problema de este estudio fue: ¿Cuáles son los factores relacionados al abandono del método anticonceptivo hormonal en mujeres en el centro de salud Chilca-Huancayo 2022? Sostuvo como objetivo. Determinar los factores relacionados al abandono del método anticonceptivo hormonal en mujeres en el centro de salud Chilca-Huancayo 2022. La metodología fue la siguiente: científica, básica, no experimental, transversal y prospectivo, entre las 148 mujeres que componen la población. Se empleó un cuestionario para obtener datos. Resultados: las peculiaridades de las mujeres son: la edad entre los 25 a 29 años (29.2 %), grado de instrucción secundaria (54.7%), convivientes (60,4%), católicas (84,9%), ama de casa (39.6%), el método anticonceptivo que con mayor frecuencia se abandona es el inyectable trimestral, con un 44,34% según estos resultados el factor personal (rs =0,242) está más relacionado al abandono del empleo de métodos anticonceptivos, sociocultural (rs =0,060), clínico (rs =0,397) y el factor el institucional con el (rs =0,225) Conclusiones: Existe una correlación baja (rs =0,37) entre los factores socioculturales, personales, clínicos e institucionales y abandono del método anticonceptivo hormonal. Recomendación: fortalecer las debilidades del personal obstétrico para brindar una mejor atención a las usuarias y garantizar la continuidad de la aplicación de métodos anticonceptivos hormonales

Carbon Nitride-Perovskite Composites: Evaluation and Optimization of Photocatalytic Hydrogen Evolution in Saccharides Aqueous Solution

The application of hybrid photocatalysts made of carbon nitride and lead-free perovskites, namely DMASnBr3/g-C3N4 and PEA2SnBr4/g-C3N4, for the H2 evolution from saccharides aqueous solution is described. The novel composites were tested and compared in terms of hydrogen evolution rate (HER) under simulated solar light, using Pt as a reference co-catalyst, and glucose as a representative sacrificial biomass. The conditions were optimized to maximize H2 generation by a design of experiments involving catalyst amount, glucose concentration and Pt loading. For both materials, such parameters affected significantly H2 photogeneration, with the best performance observed using 0.5 g L−1 catalyst, 0.2 M glucose and 0.5 wt% Pt. Under optimized conditions, DMASnBr3/g-C3N4 showed a 5-fold higher HER compared to PEA2SnBr4/g-C3N4, i.e., 925 µmoles g−1 h−1 and 190 µmoles g−1 h−1, respectively (RSD ≤ 11%, n = 4). The former composite, which affords an HER 15-fold higher in aqueous glucose than in neat water, provided H2 also with no metal co-catalyst (around 140 µmoles g−1 h−1), and it was reusable for at least three photoreactions. Encouraging results were also collected by explorative tests on raw starch solution (around 150 µmoles g−1 h−1)