EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

La tectonique cisaillante polyphasee du Sud Limousin (Massif central francais) et son interpretation dans un modele d'evolution polycyclique de la chaine hercynienne

Structural, kinematics and thermo-barometric analyses of the ductile deformation of the south-Limousin metamorphic formations show a polyphase shear tectonics corresponding to two different thrusting events. The older one, is a to the top-to-the-SW thrusting during middle Devonian. This deformation occurs under minimum PT conditions of 7 Kbar/700 degrees C simultaneously to anatexis. The second event is a top-to-the-NW shearing which occurred in late Devonian-early Carboniferous under Barrovian conditions (5 kbar/600 degrees C). Diorites bodies and non-eclogitized mafic rocks allow us to argue for an extensional phase between the two thrusting events. These two ductile and syn-metamorphic deformations take place in a polycyclic evolution model of the Hercynian belt of the French Massif Central

A double Fe-Ti oxide and Fe-sulphide liquid immiscibility in the Itsindro Gabbro Complex, Madagascar

International audienc

Superimposed tectonic and hydrothermal events during the late-orogenic extension in the western French massif central: a structural and 40Ar/39Ar study.

In the Western French Massif Central, the Argentat fault is a major structure through which As–Au fluids percolated in the Late Carboniferous along brittle fractures. New petrostructural investigations show that an early ductile normal-dextral faulting, coeval to leucogranite emplacement took place during the Late Visean syncollisional extension of the belt and was accompanied by a hydrothermal event marked by the growth of muscovites whose 40Ar/39Ar ages cluster around 335 Ma. This early fluid channelling is associated with brittle deformation only in the hangingwall of the Argentat fault, whereas ductile deformation is restricted to the footwall. These results provide new evidence for the upper crust implication during the syncollisional extension in the French Massif Central. This study stresses the interest of a detailed multimethod analysis to characterize hydrothermal processes, especially in basement areas where the tectonic, plutonic and metamorphic evolution is polyphased

Evidence for Fe-sulfide and Fe-Ti oxide liquid immiscibility in the Itsindro gabbro Complex, Madagascar

International audienceThe petrology and mineralogy of the Itsindro complex, SW Madagascar has been investigated through samples coming from a borehole drilled, in the early 70’s, in a geophysical and Ni-,Cu-geochemical anomaly. The host rocks are represented by a pyroxenite unit with interbedded gabbro layers and a gabbro unit. A decrease of the Mg number of CPX, independent of the lithology, is observed from the deepest samples (316 m) up to 163 m suggesting a regular fractional crystallization process. The evolution of this parameter is more erratic in the upper part of the bore hole. The mineralisation consists in Fe-Ti-P oxides and Fe-(Cu-Ni) sulfides. The ilmenite-magnetite±apatite and pyrrhotite±chalcopyrite ±pent-landite assemblages are always observed in interstitial position. The contemporaneous character of the oxide and sulfide assemblages strongly suggests a two stages evolution of the tholeitic magma, a first immiscibility process between a Si-rich and a Fe-Ti-P liquids followed by a sulfide contamination of the latter giving way to massive Fe-rich over Cu- Ni sulphides

Autochtonous greenstone belts of Madagascar : Implication for the archean tectonics in the frame of the greater darwhar craton

International audienceThe new geochronologic, petrologic and structural data acquired during the mapping project of the Programme de Gouvernance des Ressources Minérales de Madagascar, completed by academic works, lead to the re-definition of eight geological domains which make up the metamorphic Malagasy basement. The Center of the Island only consists of the Antananarivo and Antongil/Masora domain respectively. The Paleo- Mesoarchean Antongil/Masora domain (3.32-3.15 Ga) is interpreted as a fragment of the wider Dharwar craton of India. Its adjacent Neoarchean Antananarivo domain (2.7-2.5 Ga) is well know because it comprises a critical component of mafic-ultramafic gneisses which crop out as five N-striking belts interpreted as Archaean metamorphosed greenstone belts referred hereafter as “Tsaratanana Complex”. ,In the conventional view, the Tsaratanana complex is interpreted as a single allochthonous unit thrust over granitoid gneisses of the Antananarivo block during the Panafrican orogeny. Two aspects of this notion are controversial: (i) the age of the allochthon’s emplacement and (ii) the very nature of the allochthon itselfWe present new structural data and U-Pb isotopic ages arguing that neither the structural evolution nor the age constraints of the identified geological events are consistent with an allochtonous model of nappe tectonics. On the contrary, the “Tsaratanana Complex” is likely an autochthonous domain or was juxtaposed with the Antananarivo Domain in the late Archean / Early Palaeoproterozoic times. In this way, the Antananarivo Domain and the associated “Tsaratanana Complex” does not differ from the Eastern Dharwar Craton. Consequently, the reliability of the “Betsimisaraka suture” is discussed and we propose that Neoarchean rocks of the Eastern Dharwar Craton and the Antananarivo domain were symmetrically disposed around the Mesoarchaean nucleus formed by the Western Dharwar Craton and the Antongil/masora Domain as earlier as Neoarchean times

A Route to “all-cis” 2-Methyl-6-Substituted Piperidin-3-ol Alkaloids from syn-(2R,1′S)-2-(1-Dibenzylaminomethyl)epoxide: Rapid Total Synthesis of (+)-Deoxocassine

International audienceA general strategy leading to the synthesis of two cis-2methyl-6-substituted piperidin-3-ols is described. syn-(2R,1ЈS)-2-(1-Dibenzylaminomethyl) epoxide (13) was used as common building block. The key step involved oxirane ring opening of 13 by the nucleophilic lithium aza-enolate o

Highly Enantioselective Access to alpha-Dibenzylamino Ketones from Chiral Nonracemic alpha-Bromo alpha'-Sulfinyl Ketones by Dynamic Kinetic Resolution: Synthesis of (2R, 1'S)-2-[1-(Dibenzylamino)alkyl]oxiranes

International audienceA novel and efficient synthesis of enantiomerically pure alpha-dibenzylamino alpha'-sulfinyl ketones starting from a mixture of both epimers of alpha-bromo alpha'-(R)-sulfinyl Ketone has been realized through combined in situ substitution-epimerization in so-called Dynamic Kinetic Resolution (DKR). The scope of the reaction has been examined, and four differently substituted alpha-(S)-dibenzylamino alpha'-(R)-sulfinyl ketones were obtained in good yields with excellent diastereoselectivities. The utility of these derivatives was further illustrated with a highly stereoselective synthesis of syn-(2R, 1'S)-2-(1-dibenzylaminoalkyl)oxiranes

A Divergent Synthetic Strategy Based on the Regioselective Reductive Ring-Opening of a Cyclic 1,2-p-Methoxybenzylidene Acetal

International audienceDibenzyl-1-[(4R)-2-(4-methoxyphenyl)-1,3dioxolan-4-yl]ethanamine is obtained in five steps from an abromo-a¢-(R)-sulfinyl ketone and is used as a common intermediate for the synthesis of the p-methoxybenzyl-protected primary and secondary alcohols, (2R,3S)-3-(dibenzylamino)-2-[(4-methoxybenzyl)oxy]butan-1-ol and (2R,3S)-3-(benzylamino)-1-[(4-methoxybenzyl)oxy]butan-2-ol, respectively. These alcohols are further exploited as precursors for the synthesis of a fully protected syn-3amino-2-hydroxybutanoic acid and an N-benzyl 2-hydroxymethylaziridine

Pre-, syn- and post-breakup evolution of northern South America from apatite fission track data and inverse thermal history modelling

International audiencePhanerozoic evolution of the Guiana Shield in northern South America is poorly known and remains an important question for source-to-sink studies. As part of the Source to Sink project TOTAL R&D-BRGM-INSU, this study presents a suite of 40 new apatite fission track analysis results from French Guiana, Surinam and north Brazil. Inverse thermal history modelling reveals a marked, albeit poorly constrained, period of relatively high temperatures (temperatures > 110 °C) during the Jurassic (200-150 Ma), i.e. prior to the generally accepted timing of the Equatorial Atlantic Ocean opening (150-110 Ma). Lower temperatures are recorded on the southerm flank of the Amazonas Basin and a little portion of the Surinam interior. All data reveal then a protracted phase of cooling starting from ~150 Ma and representing the main event during the Mesozoic and Cenozoic for French Guiana and Surinam basement. A second thermal event is nevertheless recorded after the deposition of Upper Jurassic and Lower Cretaceous detrital sedimentary rocks on the northern flank of the Amazonas Basin. Maximum temperatures for this event (80-100 °C) are reached during the middle Cretaceous (115-90 Ma). Implications of these new results for the Guiana Shied evolution and the Equatorial Atlantic opening are discussed