Intracranial extramedullary hematopoiesis in a thalassemic girl: A Case report

Beta-thalassemia is a haemolytic disorder with ineffective erythropoiesis and red blood cell destruction. Extramedullary hematopoiesis is one of the complications associated with beta-thalassemia. Extramedullary hematopoiesis is the ectopic production of blood cells outside the marrow in liver, spleen, lymph nodes and many other sites. Intracranial involvement is extremely rare. We report a case of 17-year-old girl with thalassemia major and intracranial extramedullary hematopoiesis who came with the complaints of seizure, headache and generalised weakness. Imaging and blood profile leads to the final diagnosis with MRI playing a key role and patient was managed successfully. With this report, we discuss the imaging findings of intracranial extramedullary hematopoiesis in details

Lipoma of Guyon’s canal causing ulnar neuropathy

Lipoma is a benign soft tissue tumor which rarely causes neuropathy. In closed compartments such as Guyon’s canal, even small volume loss can lead to compression of nerve. Hence in such areas, even innocuous tumors such as lipomas can cause neuropathy and warrant surgery. We present one such case of ulnar neuropathy caused by lipoma of Guyon’s canal

Meniscal ossicle

Meniscal ossicle, or bone within the substance of meniscus, is a rare entity and commonly confused with a loose body both clinically and radiologically. MRI is the modality that can definitely diagnose meniscal ossicle and avoid unnecessary diagnostic arthroscopy. Here we report one such case diagnosed using MRI; this patient is doing well without surgery one year after diagnosis

rCBV- and ADC-based Grading of Meningiomas With Glimpse Into Emerging Molecular Diagnostics

Introduction: This study was conducted to grade meningiomas based on relative Cerebral Blood Volume (rCBV) and Apparent Diffusion Coefficient (ADC) to help surgeons plan the approach and extent of operation as well as decide on the need of any adjuvant radio/chemo therapy. The current and evolving genomic, proteomic, and spectroscopic technologies are also discussed which can supplement the current radiologic methods and procedures in grading meningiomas. Methods: A total of 35 patients with meningioma prospectively underwent basic MR sequences (T1W, T2W, T2W/FLAIR) in axial, sagittal and coronal planes followed by Diffusion Weighted (DW) imaging having b value of 1000 (minimum ADC values used for analysis). Then, gadobenate dimeglumine/meglumine gadoterate was administered (0.1 mmol/kg at a rate of 4 mL/s) followed by saline flush (20 mL at a rate of 4 mL/s). Next, T2*W/FFE dynamic images were acquired; dynamics showing maximum fall in intensity was used for creating rCBV and relative Cerebral Blood Flow (rCBF) maps and calculating rCBV. Results: Both maximum rCBV and minimum ADC within the tumor were not significant for differentiating benign from malignant meningiomas. A cut-off maximum rCBV of 2.5 mL/100 g in peritumoral edema was 75% sensitive, 84.6% specific, and 83.3% accurate in differentiating benign from malignant meningiomas.  Conclusion: Benign and malignant meningiomas can be differentiated based on maximum rCBV in peritumoral edema but ADC values within the tumor are insignificant in differentiating benign and malignant tumors. rCBV values within tumor, however, may be helpful in subtyping meningiomas, especially transitional and meningothelial meningiomas

Clinico-epidemiological profile of early cases of Covid-19 in state of Haryana, India

Background: Covid -19 disease is caused by novel coronavirus known as SARS CoV 2. Coronaviruses are known to cause disease in humans which can be a common cold or a serious pneumonia. SARS Cov 2 is a new variant of coronavirus which was never reported in humans before detection of cluster of cases of pneumonia in Wuhan on 31st December, 2019.Objective: The study was conducted with the objective to find out clinico- epidemiological profiles of early Covid-19 patients in state of Haryana, India and to find out knowledge about covid appropriate behaviors among covid 19 patients. Methods: All the covid-19 cases in the five districts of Haryana were enumerated from March 2020 to May 2020. These Covid-19 cases were contacted telephonically and those who gave their consent to participate in the study were asked to fill interview schedule. Observations: There were 356 covid cases reported in five districts attached to PGIMS, Rohtak. Out of total,254 subjects participated in the study, there were 60.6 % males and 39.4% females who participated in the study. Blood groups of all the participants were also enquired and it was observed that B +ve was most common (19.7%) blood group followed by A+ve (16.5%) and O +ve (15.7%). Conclusion: It can be concluded by the study that majority of the subjects were males, overweight and blood group A & B were the most common blood groups. It was observed that 75.2 % participants were aware about the use of mask, social distancing, hand hygiene and cough etiquettes