28 research outputs found
The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification
Interrelations of Maternal Expressed Emotion, Maltreatment, and Separation/Divorce and Links to Family Conflict and Children’s Externalizing Behavior
Are Two Voices Better Than One? Predicting Permanency in Minority Youth Using Multi-informant Mental Health and Strength Data
The Relations among Maternal Depressive Disorder, Maternal Expressed Emotion, and Toddler Behavior Problems and Attachment
Child Abuse and Neglect, Callous-Unemotional Traits, and Substance Use Problems: the Moderating Role of Stress Response Reactivity
Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds
BackgroundAim of this study was to evaluate the potential of fecal volatile organic compounds (VOC), obtained by means of an electronic nose device (Cyranose 320®), as early non-invasive biomarker for BPD.MethodsIn this nested case-control study performed at three Neonatal Intensive Care Units, fecal samples obtained at postnatal age of 7, 14, 21 and 28 days, from preterm infants with severe BPD, were compared with fecal VOC profiles from matched controls. Microbiota analysis was performed by means of IS-pro technique on fecal samples collected at 28 days postnatally.ResultsVOC profiles of infants developing severe BPD (n=15) could be discriminated from matched controls (n=15) at postnatal age of 14 days (area under the curve [±95% confidence interval], p-value, sensitivity, specificity; 0.72 [0.54-0.90], 0.040, 60.0%, 73.3%), 21 days (0.71 [0.52-0.90], 0.049, 66.7%, 73.3%) and 28 days (0.77 [0.59-0.96], 0.017, 69.2%, 69.2%), but not at 7 days. Intestinal microbiota did not differ between BPD subjects and controls.ConclusionFecal VOC profiles of infants developing BPD could be differentiated from controls at postnatal day 14, 21 and 28. VOC differences could not be directed to intestinal microbiota alterations but presumably reflect local and systemic metabolic and inflammatory pathways associated with BPD.Pediatric Research accepted article preview online, 20 October 2017. doi:10.1038/pr.2017.26