Lycoris -- a large-area, high resolution beam telescope

A high-resolution beam telescope is one of the most important and demanding infrastructure components at any test beam facility. Its main purpose is to provide reference particle tracks from the incoming test beam particles to the test beam users, which allows measurement of the performance of the device-under-test (DUT). \LYCORIS, a six-plane compact beam telescope with an active area of $\sim$10$\times$\SI{10}{\square\centi\metre} (extensible to 10$\times$\SI{20}{\square\centi\metre}) was installed at the \DIITBF in 2019, to provide a precise momentum measurement in a \SI{1}{\tesla} solenoid magnet or to provide tracking over a large area. The overall design of \LYCORIS will be described as well as the performance of the chosen silicon sensor. The \SI{25}{\micro\metre} pitch micro-strip sensor used for \LYCORIS was originally designed for the \SID detector concept for the International Linear Collider. It adopts a second metallization layer to route signals from strips to the bump-bonded \KPIX ASIC and uses a wire-bonded flex cable for the connection to the DAQ and the power supply system. This arrangement eliminates the need for a dedicated hybrid PCB. Its performance was tested for the first time in this project. The system has been evaluated at the \DIITBF in several test-beam campaigns and has demonstrated an average single-point resolution of \SI{7.07}{\micro\meter}.Comment: 43 pages, 37 figure

Lycoris: A large area beam telescope based on hybrid-less strip silicon sensors

A new Large area x-Y COverage Readout Inte- grated Strip telescope (LYCORIS ) is being constructed as an improvement of the DESY test beam infrastructure within the Horizon2020 AIDA-2020 project. The LYCORIS telescope consists of six layers of 25 μm pitch strip Si sensor readout by two bump-bonded ASICs (KPiX), running at a timing resolution as multiples of 80 ns; its active area is designed to be 10×10 cm2 , extendable to 10×20cm2. It can run either standalone or be mounted inside a 1T solenoid magnet, providing a spatial resolution better than 10μm along the bending direction, and a resolution better than 1 mm along the magnetic field. The full readout system was tested with a hexagonal pixel sensor designed for the SiD ECAL in the lab with a 90Sr source, and later tested in the electron beam at DESY in May and October 2017. The first assembled modules with the final strip were tested in spring 2018. First results of the LYCORIS prototype will be presented with a comparison to simulation, besides, the characterization of sensor and readout system are also included

Development of a large active area beam telescope based on the SiD microstrip sensorI

A beam telescope as one of the most important and often requested test beam equipment provides particle tracking to test beamusers. At the DESY II test beam facility, a new beam telescope called Lycoris based on a microstrip sensor has been designed toaddress the user demands for momentum measurement in a 1 T solenoid magnet or large area tracking with limited space (3:5 cmbetween the potential user device and the magnet inner wall). Lycoris is designed to provide a high-precision resolution of at least10 µm along the bending direction, and a large active area of 1010 cm2 to cover at least 90% of the beam particles at energies of1-6 GeV. The microstrip sensor was originally designed for the Silicon Detector (SiD) at the International Linear Collider (ILC),which adopted a hybrid-less design, i.e. a second metallization layer is used to route signals from strips to the bump-bonded ASIC,and from the ASIC to a wire-bond pad to the outside. This hybrid-less arrangement eliminates the need for a complex hybriddesign, and its functioning is first-time tested in this project. The performance of the sensor modules was firstly tested in the labthen at the DESY II test beam facility in August/September 2018, and the results will be presented here. In addition, a summarywill be given at the end with an overview of the ongoing test beam campaign of the Lycoris prototype in February 2019

Lycoris: A large area beam telescope based on hybrid-less silicon sensors

A new Large area x-Y COverage Readout Inte- grated Strip telescope (LYCORIS ) is being constructed as an improvement of the DESY test beam infrastructure within the Horizon2020 AIDA-2020 project. The LYCORIS telescope consists of six layers of 25 μm pitch strip Si sensor readout by two bump-bonded ASICs (KPiX), running at a timing resolution as multiples of 80 ns; its active area is designed to be 10×10 cm2 , extendable to 10×20cm2. It can run either standalone or be mounted inside a 1T solenoid magnet, providing a spatial resolution better than 10μm along the bending direction, and a resolution better than 1 mm along the magnetic field. The full readout system was tested with a hexagonal pixel sensor designed for the SiD ECAL in the lab with a 90Sr source, and later tested in the electron beam at DESY in May and October 2017. The first assembled modules with the final strip were tested in spring 2018. First results of the LYCORIS prototype will be presented with a comparison to simulation, besides, the characterization of sensor and readout system are also included

Development of a large active area beam telescope based on the SiD micro-strip sensor

A new beam telescope, Lycoris, is currently being installed as an improvement for the DESY test beam infrastructure within the EU Horizon2020 AIDA-2020 project. Lycoris telescope is designed to cover a large area for providing a reference momentum measurement to beam users in an 1 T solenoid magnet. It consists of six layers of the 10×10 cm2 surface, 25 μm(50 μm) sensor(readout) pitch, single-sided silicon strip sensor, giving a spatial resolution better than 10 μm along the bending direction. The micro-strip sensor is designed for the SiD tracker, readout by two bump-bonded, KPiX ASICs, which digitizes and serializes signals from all connected strips, then sends out via one single wire-bonded data trace. This hybrid-less arrangement enables Lycoris to accommodate 3 layers of the hybrid-less SiD sensor in 3.2 cm space. The presentation will first introduce the telescope with its components, then characterization results of the sensor modules will be given based on the beam tests in August and September 2018. At the end, the first beam test results of the Lycoris telescope prototype will be shown with a comparison to the simulation

Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury

Critically ill patients are at a constant risk of direct (e.g., by pneumonia) or indirect lung injury (e.g., by sepsis). Excessive alveolar fibrin deposition is a prominent feature of lung injury, undermining pulmonary integrity and function. We examined the effect of local administration of recombinant human tissue factor pathway inhibitor (rh-TFPI), a natural anticoagulant, in two well-established models of lung injury in rats. Rats received intratracheal instillation of Pseudomonas aeruginosa, causing direct lung injury, or they received an intravenous injection of Escherichia coli lipopolysaccharide (LPS), causing indirect lung injury. Rats were randomized to local treatment with rh-TFPI or placebo through repeated nebulization. Challenge with P. aeruginosa or LPS was associated with increased coagulation and decreased fibrinolysis in bronchoalveolar lavage fluid (BALF) and plasma. Rh-TFPI levels in BALF increased after nebulization, whereas plasma rh-TFPI levels remained low and systemic TFPI activity was not affected. Nebulization of rh-TFPI attenuated pulmonary and systemic coagulation in both models, without affecting fibrinolysis. Nebulization of rh-TFPI modestly reduced the inflammatory response and bacterial growth of P. aeruginosa in the alveolar compartment. Local treatment with rh-TFPI does not alter systemic TFPI activity; however, it attenuates both pulmonary and systemic coagulopathy. Furthermore, nebulized rh-TFPI modestly reduces the pulmonary inflammatory response and allows increased bacterial clearance in rats with direct lung injury caused by P. aeruginos

Short-term Changes in Health-related Quality of Life of Patients Undergoing Radical Surgery for Upper Urinary Tract Urothelial Carcinoma:Results from a Prospective Phase 2 Clinical Trial

Background and objective: The possible negative impact of radical surgery on patients’ health-related quality of life (HRQoL) plays an important role in preoperative counseling. Here, we analyzed the HRQoL of patients treated for upper urinary tract urothelial carcinoma (UTUC) in the context of a single-arm phase 2 multicenter study, in which the safety and efficacy of a single preoperative intravesical instillation with mitomycin C were investigated. Our objective was to investigate early changes in HRQoL in patients undergoing radical surgery for UTUC and identify factors associated with these outcomes. Methods: Patients with pTanyN0-1M0 UTUC were prospectively included. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) questionnaire at baseline, and at 1 and 3 mo after surgery. A linear mixed model was used to evaluate the changes in HRQoL over time and identify the variables associated with these outcomes. The clinical effect size was used to assess the clinical impact and level of perceptibility of HRQoL changes for clinicians and/or patients based on given thresholds. Key findings and limitations: Between 2017 and 2020, 186 patients were included. At baseline, 1 mo after surgery, and 3 mo after surgery, response rates were 91%, 84%, and 78%, respectively. One month after surgery, a statistically significant and clinically relevant deterioration was observed in physical, role, and social functioning, and for the included symptom scales: constipation, fatigue, and pain. An improvement in emotional functioning was observed. At 3 mo, HRQoL returned to baseline levels, except emotional functioning, which improved at 1 mo and persisted to be better than that before surgery. Age &gt;70 yr was associated with worse physical functioning, but better social and emotional functioning. Male patients reported better emotional functioning than females. Postoperative complications were negatively associated with social functioning. Conclusions and clinical implications: UTUC patients treated with radical surgery experienced a significant, albeit temporary, decline in HRQoL. Three months following surgery, HRQoL outcomes returned to baseline levels. This information can be used to counsel UTUC patients before undergoing radical surgery and contextualize recovery after surgery. Patient summary: We investigated the changes in quality of life as reported by patients who underwent surgery for upper tract urothelial carcinoma (UTUC). We found that patients experienced a decline in quality of life 1 mo after surgery, but this was temporary, with full recovery of quality of life 3 mo after surgery. These findings can help doctors and other medical staff in counseling UTUC patients before undergoing radical surgery.</p