10,444 research outputs found
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.
Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors
Acoustic Identification of Liquefaction Potential
The interparticle arrangement, or fabric, of sands is a key determinant of sample rigidity. This rigidity, in large part, determines the velocity and attenuation of acoustic transmissions in a test specimen, as well as its resistance to liquefaction. Utilizing high frequency small-amplitude compressional wave transmissions, different fabric arrangements of standard triaxial samples of the same sand have been reliably identified from their acoustic response. Both the compressional wave velocity and attenuation were used to determine the acoustic signature of a sample. Cyclic triaxial testing of the same laboratory-prepared samples revealed that there is direct relationship between the acoustic response of a sample prepared by a particular method and its resistance to liquefaction. The effect of stress history, induced by pre-shaking, on the resistance to liquefaction of a test sample was also detected by changes in the acoustic signature
Localizations at infinity and essential spectrum of quantum Hamiltonians: I. General theory
We isolate a large class of self-adjoint operators H whose essential spectrum
is determined by their behavior at large x and we give a canonical
representation of their essential spectrum in terms of spectra of limits at
infinity of translations of H. The configuration space is an arbitrary abelian
locally compact not compact group.Comment: 63 pages. This is the published version with several correction
The impact of viscosity on the morphology of gaseous flows in semidetached binary systems
Results of 3D gas dynamical simulation of mass transfer in binaries are
presented for systems with various values of viscosity. Analysis of obtained
solutions shows that in the systems with low value of viscosity the flow
structure is qualitatively similar to one for systems with high viscosity.
Presented calculations confirm that there is no shock interaction between the
stream from L1 and the forming accretion disk (`hot spot') at any value of
viscosity.Comment: LaTeX, 18 pages, 15 eps-figures, Astron. Reports, in pres
Projective Ribbon Permutation Statistics: a Remnant of non-Abelian Braiding in Higher Dimensions
In a recent paper, Teo and Kane proposed a 3D model in which the defects
support Majorana fermion zero modes. They argued that exchanging and twisting
these defects would implement a set R of unitary transformations on the zero
mode Hilbert space which is a 'ghostly' recollection of the action of the braid
group on Ising anyons in 2D. In this paper, we find the group T_{2n} which
governs the statistics of these defects by analyzing the topology of the space
K_{2n} of configurations of 2n defects in a slowly spatially-varying gapped
free fermion Hamiltonian: T_{2n}\equiv {\pi_1}(K_{2n})$. We find that the group
T_{2n}= Z \times T^r_{2n}, where the 'ribbon permutation group' T^r_{2n} is a
mild enhancement of the permutation group S_{2n}: T^r_{2n} \equiv \Z_2 \times
E((Z_2)^{2n}\rtimes S_{2n}). Here, E((Z_2)^{2n}\rtimes S_{2n}) is the 'even
part' of (Z_2)^{2n} \rtimes S_{2n}, namely those elements for which the total
parity of the element in (Z_2)^{2n} added to the parity of the permutation is
even. Surprisingly, R is only a projective representation of T_{2n}, a
possibility proposed by Wilczek. Thus, Teo and Kane's defects realize
`Projective Ribbon Permutation Statistics', which we show to be consistent with
locality. We extend this phenomenon to other dimensions, co-dimensions, and
symmetry classes. Since it is an essential input for our calculation, we review
the topological classification of gapped free fermion systems and its relation
to Bott periodicity.Comment: Missing figures added. Fixed some typos. Added a paragraph to the
conclusio
The structure of cool accretion disc in semidetached binaries
We present the results of qualitative consideration of possible changes
occurring during the transition from the hot accretion disc to the cool one. We
argue the possible existence of one more type of spiral density waves in the
inner part of the disc where gasdynamical perturbations are negligible. The
mechanism of formation of such a wave as well as its parameters are considered.
We also present the results of 3D gasdynamical simulation of cool accretion
discs. These results confirm the hypothesis of possible formation of the spiral
wave of a new, "precessional" type in the inner regions of the disc. Possible
observational manifestations of this wave are discussed.Comment: LaTeX, 16 pages, 8 figures, to be published in Astron. Z
Reye Syndrome Associated with Vaccination with Live Virus Vaccines
To determine whether vaccination with live virus vaccines may be etiologi cally related to Reye syndrome, we examined 404 cases reported to the Center for Disease Control. Fifteen of 269 children with Reye syndrome had been inoculated with live virus vaccines within 30 days before onset of illness. Although this temporal relationship may have occurred by chance, seasonal distribution and clustering of incubation periods suggests that live virus vaccines may occasionally serve as cofactors in the etiology of Reye syndrome through undefined mechanisms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66647/2/10.1177_000992287901800105.pd
Radiation Testing of Electronics for the CMS Endcap Muon System
The electronics used in the data readout and triggering system for the
Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC)
particle accelerator at CERN are exposed to high radiation levels. This
radiation can cause permanent damage to the electronic circuitry, as well as
temporary effects such as data corruption induced by Single Event Upsets. Once
the High Luminosity LHC (HL-LHC) accelerator upgrades are completed it will
have five times higher instantaneous luminosity than LHC, allowing for
detection of rare physics processes, new particles and interactions. Tests have
been performed to determine the effects of radiation on the electronic
components to be used for the Endcap Muon electronics project currently being
designed for installation in the CMS experiment in 2013. During these tests the
digital components on the test boards were operating with active data readout
while being irradiated with 55 MeV protons. In reactor tests, components were
exposed to 30 years equivalent levels of neutron radiation expected at the
HL-LHC. The highest total ionizing dose (TID) for the muon system is expected
at the inner-most portion of the CMS detector, with 8900 rad over ten years.
Our results show that Commercial Off-The-Shelf (COTS) components selected for
the new electronics will operate reliably in the CMS radiation environment
- …