Food safety

Food safety, in general terms, concerns every step of food production from farm to fork. Owing to several factors, such as changes in demographical and social conditions, access to information, and better understanding of what are healthy foods, people from all around the world are demanding high-quality and safe food products. Apart from the sensorial characteristics, the final products must be free of external contaminants. These contaminants could be potentially harmful to the final consumer, being classified as biological, chemical, and physical hazards. Therefore, this chapter presents an overview of the main food-borne hazards, the current context of food safety, food safety concepts throughout the food production chain, and the role of regulatory agencies in food safety.Fil: Chaves, R. D.. Universidade Estadual de Campinas; BrasilFil: Alvarenga, V. O.. Universidade Estadual de Campinas; BrasilFil: Campagnollo, F. B.. Universidade Estadual de Campinas; BrasilFil: Rodriguez Caturla, M. Y.. Universidade Estadual de Campinas; BrasilFil: Oteiza, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina. Centro de Investigación y Asistencia Técnica a la Industria; ArgentinaFil: Sant'Ana, Anderson de Souza. Universidade Estadual de Campinas; Brasi

Preparation of Mo-embedded mesoporous carbon microspheres for friedel-crafts alkylation

10.1021/jp211718wJournal of Physical Chemistry C116147767-777

Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction

Background: Current fibrinolytic therapies fail to achieve optimum reperfusion in many patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have shown the potential to improve pharmacological reperfusion therapy. We did a randomised, open-label trial to compare the efficacy and safety of tenecteplase plus enoxaparin or abciximab, with that of tenecteplase plus weight-adjusted unfractionated heparin in patients with acute myocardial infarction. Methods: 6095 patients with acute myocardial infarction of less than 6 h were randomly assigned one of three regimens: full-dose tenecteplase and enoxaparin for a maximum of 7 days (enoxaparin group; n=2040), half-dose tenecteplase with weight-adjusted low-dose unfractionated heparin and a 12-h infusion of abciximab (abciximab group; n=2017), or full-dose tenecteplase with weight-adjusted unfractionated heparin for 48 h (unfractionated heparin group; n=2038). The primary endpoints were the composites of 30-day mortality, in-hospital reinfarction, or in-hospital refractory ischaemia (efficacy endpoint), and the above endpoint plus in-hospital intracranial haemorrhage or in-hospital major bleeding complications (efficacy plus safety endpoint). Analysis was by intention to treat. Findings: There were significantly fewer efficacy endpoints in the enoxaparin and abciximab groups than in the unfractionated heparin group: 233/2037 (11.4%) versus 315/2038 (15.4%; relative risk 0.74 [95% CI 0.63-0.87], p=0.0002) for enoxaparin, and 223/2017 (11.1%) versus 315/2038 (15.4%; 0.72 [0.61-0.84], p<0.0001) for abciximab. The same was true for the efficacy plus safety endpoint: 280/2037 (13.7%) versus 347/2036 (17.0%; 0.81 [0.70-0.93], p=0.0037) for enoxaparin, and 287/2016 (14.2%) versus 347/2036 (17.0%; 0.84 [0.72-0.96], p=0.01416) for abciximab. Interpretation: The tenecteplase plus enoxaparin or abciximab regimens studied here reduce the frequency of ischaemic complications of an acute myocardial infarction. In light of its ease of administration, tenecteplase plus enoxaparin seems to be an attractive alternative reperfusion regimen that warrants further study