The L2 acquisition of syllable structure and stress in Spanish.

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Climate services and insurance: scaling climate smart agriculture

One of the main challenges of climate-smart agriculture (CSA) is finding ways to promote the adoption at scale (Editor’s note: 'scaling', 'at scale' or 'to scale' are used throughout this article to mean ‘scaling-out’) of CSA practices and technologies. Climate services and insurance can constitute a tool to scale CSA by providing an enabling environment that can support the adoption of CSA practices while protecting against the impacts of climate extremes. By using a definition of climate services which includes the production, translation, transfer, and use of climate knowledge and information in climate-informed decision-making and climatesmart policy and planning, this paper aims to discuss how climate services and insurance can bring CSA to scale. Three case studies are presented. It is recognised that understanding the knowledge networks through which information flows, and affects the use of climate information, is critical for promoting CSA at scale

Estado del Arte en Cambio Climático, Agricultura y Seguridad Alimentaria de la República Dominicana

La República Dominicana es un país con un alto nivel de exposición y vulnerabilidad a eventos climáticos extremos a nivel mundial; es por esto que el Ministerio de Agricultura (MA) en colaboración con el Programa de Investigación CGIAR en Cambio Climático, Agricultura y Seguridad Alimentaria (CCAFS, por sus siglas en inglés) en América Latina y con apoyo del Consejo Agropecuario Centroamericano (CAC) presentan el “Estado del Arte en Cambio Climático, Agricultura y Seguridad Alimentaria de la República Dominicana”, que incluye el marco gubernamental y actores involucrados en torno a esta temática. En el documento se evidencia como los efectos del cambio climático han afectado el campo dominicano en gran parte de sus cultivos y como el gobierno ha venido enfatizando esfuerzos para disminuir la vulnerabilidad de la población y aumentar su resiliencia mediante políticas públicas y acciones integrales

Isolation and analysis of phospholipids in dairy foods

The lipid fraction of milk is one of the most complex matrixes in foodstuffs due to the presence of a high number of moieties with different physical and chemical properties. Glycerolipids include glycerol and two fatty acids esterified in positions sn-1 and sn-2 with higher concentration of unsaturated fatty acids than in the triglyceride fraction of milk. Sphingolipids consist of a sphingoid base linked to a fatty acid across an amide bond.Their amphiphilic nature makes them suitable to be added into a variety of foods and recent investigations showthat phospholipids,mainly phosphatidylserine and sphingomyelin, can exert antimicrobial, antiviral, and anticancer activities as well as positive effects in Alzheimer’s disease, stress, and memory decline. Polar lipids can be found as natural constituents in the membranes of all living organisms with soybean and eggs as the principal industrial sources, yet they have low contents in phosphatidylserine and sphingomyelin. Animal products are rich sources of these compounds but since there are legal restrictions to avoid transmission of prions,milk and dairy products are gaining interest as alternative sources.This review summarizes the analysis of polar lipids in dairy products including sample preparation (extraction and fractionation/isolation) and analysis by GC or HPLC and the latest research works using ELSD, CAD, and MS detectors.info:eu-repo/semantics/publishedVersio

The coevolution of innovation and technical intelligence in primates

In birds and primates, the frequency of behavioural innovation has been shown to covary with absolute and relative brain size, leading to the suggestion that large brains allow animals to innovate, and/or that selection for innovativeness, together with social learning, may have driven brain enlargement. We examined the relationship between primate brain size and both technical (i.e. tool using) and non-technical innovation, deploying a combination of phylogenetically informed regression and exploratory causal graph analyses. Regression analyses revealed that absolute and relative brain size correlated positively with technical innovation, and exhibited consistently weaker, but still positive, relationships with non-technical innovation. These findings mirror similar results in birds. Our exploratory causal graph analyses suggested that technical innovation shares strong direct relationships with brain size, body size, social learning rate and social group size, whereas non-technical innovation did not exhibit a direct relationship with brain size. Nonetheless, non-technical innovation was linked to brain size indirectly via diet and life-history variables. Our findings support ‘technical intelligence’ hypotheses in linking technical innovation to encephalization in the restricted set of primate lineages where technical innovation has been reported. Our findings also provide support for a broad co-evolving complex of brain, behaviour, life-history, social and dietary variables, providing secondary support for social and ecological intelligence hypotheses. The ability to gain access to difficult-to-extract, but potentially nutrient-rich, resources through tool use may have conferred on some primates adaptive advantages, leading to selection for brain circuitry that underlies technical proficiency.PostprintPeer reviewe

Plasmodium-Induced Inflammation by Uric Acid

Infection of erythrocytes with the Plasmodium parasite causes the pathologies associated with malaria, which result in at least one million deaths annually. The rupture of infected erythrocytes triggers an inflammatory response, which is induced by parasite-derived factors that still are not fully characterized. Induced secretion of inflammatory cytokines by these factors is considered a major cause of malaria pathogenesis. In particular, the inflammatory cytokine tumor necrosis factor (TNF) is thought to mediate most of the life-threatening pathologies of the disease. Here we describe the molecular characterization of a novel pathway that results in the secretion of TNF by host cells. We found that erythrocytes infected by Plasmodium accumulate high concentrations of hypoxanthine and xanthine. Degradation of Plasmodium-derived hypoxanthine/xanthine results in the formation of uric acid, which triggers the secretion of TNF. Since uric acid is considered a “danger signal” released by dying cells to alert the immune system, Plasmodium appears to have co-evolved to exploit this warning system. Identifying the mechanisms used by the parasite to induce the host inflammatory response is essential to develop urgently needed therapies against this disease

Da emigração à imigração? Por uma análise do perfil migratório brasileiro nos últimos anos

Desde a década de 80, o país era caracterizado pelo grande número de emigrantes que se dirigiam, em geral, para os Estados Unidos e para a Europa. Esse fenômeno trouxe durante muito tempo efeitos negativos para o Brasil, na medida em que tínhamos uma fuga de cérebros (brain drain), ou seja, nossa mão de obra qualificada se direcionava a estas regiões, buscando novas oportunidades profissionais. Contudo, esse panorama vem se alterando na conjuntura mais atual. O Brasil nos últimos anos, além de uma potência regional, tornou-se um dos países com maiores índices de desenvolvimento, sendo hoje a 6ª economia mundial. Sendo assim, esta comunicação tem como escopo analisar o momento de inflexão que o Brasil atravessa com vistas a verificar se, de fato, o país estaria experimentando uma transformação em seu perfil migratório, passando a assumir o papel de importador de mão de obra. Talvez ainda seja muito cedo para falar em inversão dos fluxos, mas já é possível, a partir da análise empírica, observar indícios de mudanças e, por essa razão, há a necessidade de investigarmos suas causas

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.

Tyrosine kinase inhibitors (TKIs), the treatment of choice for chronic myeloid leukaemia (CML), can cause lower gastrointestinal (GI) toxicity which is manifested as diarrhoea. The mechanisms are not fully understood. The enteroendocrine signalling compound, serotonin (5-HT), is important for regulating peristaltic motion, fluid secretion and visceral hypersensitivity in the GI tract, and has been implicated in diseases such as irritable bowel syndrome. In this study, we have evaluated whether TKI-induced diarrhoea may be related to variation in the serotonin re-uptake transporter (SERT) gene. CML patients with and without diarrhoea on the SPIRIT2 trial (imatinib, n = 319; and dasatinib, n = 297) were genotyped for the promoter 5-HTTLPR, intron 2 VNTR and rs25531 polymorphisms by PCR-based methods. Diarrhoea was more prevalent in imatinib, than in dasatinib treated patients (P = 0.015), which when stratified by gender was seen to be driven by female patients (P = 0.036). Logistic regression analysis revealed that age, and the dominant HTTLPR with the rs25531 single nucleotide polymorphism (SNP) model, explained the occurrence of diarrhoea in ~10% of imatinib-treated female CML patients. These data suggest SERT polymorphisms influence imatinib-induced diarrhoea but not that of dasatinib