Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

Introduction: We evaluated the role of cardiovascular autonomic changes in hemodynamics at rest and in response to exercise in streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into nondiabetic (ND, n = 8) and diabetic (D, n = 8) groups. Arterial pressure signals were recorded in the basal state and after atropine or propranolol injections at rest, during exercise and during recovery. Results: At rest, vagal tonus was reduced in D (37 +/- 3 bpm) in comparison with the ND group (61 +/- 9 bpm). Heart rate during exercise was lower in D in relation to ND rats associated with reduced vagal withdrawal in the D group. The D rats had an increase in vagal tonus in the recovery period (49 +/- 6 bpm). Conclusions: Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics. Muscle Nerve 46: 96101, 2012Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP- 01/00009-0, 07/57595-5, 07/58942-0]Fundacao de Amparo a Pesquisa do Estado de Sao PauloConselho Nacional de Pesquisa e DesenvolvimentoConselho Nacional de Pesquisa e Desenvolvimento [CNPq - 482520/2009-4, 306011/2010-7, 563961/2010-4]Fundacao E.J. ZerbiniFundacao E.J. ZerbiniCNPqCNP