Cordelia.’s Portrait in the Context of King Lear’s Individuation

This analysis attempts to show the relations between the individual psyche and the contents of the collective unconscious. Following Von Franz.’s analytical technique, the tragic action in King Lear will be read as an individuation process that will rescue archetypal contents and solve existential paradoxes that cause an imbalance between the ego and the self, leading to self-destruction. Once communication is eased and balance is restored, the transformation-seeking process that engaged the design of the play itself becomes resolved, and events can be led to a conventional tragic resolution. Jungian analysis will therefore provide a critical framework to unveil the subconscious contents that tear the character of the king between annihilation and survival, the anima complex that affects the king, responding thus for the action of the play and its centuries-old success. Este análisis pretende sacar a la luz las relaciones entre la psyche individual y los contenidos del inconsciente colectivo. Siguiendo la técnica analítica de Von Franz, la acción trágica de King Lear será entendida a través del proceso de individuación que revierte sobre los contenidos arquetípicos y resuelve las paradojas existenciales que causan el desequilibrio entre ego y self. Una vez que la comunicación es facilitada y el equilibrio psíquico recuperado, el proceso transformativo que afecta la génesis de la trama se resuelve y el argumento alcanza una resolución convencional. El análisis junguiano ofrece el soporte crítico necesario para desvelar los contenidos del inconsciente que escinde el personaje central del monarca entre la supervivencia y la aniquilación. El complejo de ánima que afecta al rey responde de esta manera por la complejidad de la acción dramática y el éxito que ha hecho que esta obra perdure a través de los siglos

Isotope Labelling for Reaction Mechanism Analysis in DBD Plasma Processes

Dielectric barrier discharge (DBD) plasmas and plasma catalysis are becoming an alternative procedure to activate various gas phase reactions. A low-temperature and normal operating pressure are the main advantages of these processes, but a limited energy efficiency and little selectivity control hinder their practical implementation. In this work, we propose the use of isotope labelling to retrieve information about the intermediate reactions that may intervene during the DBD processes contributing to a decrease in their energy efficiency. The results are shown for the wet reforming reaction of methane, using D2O instead of H2O as reactant, and for the ammonia synthesis, using NH3/D2/N2 mixtures. In the two cases, it was found that a significant amount of outlet gas molecules, either reactants or products, have deuterium in their structure (e.g., HD for hydrogen, CDxHy for methane, or NDxHy for ammonia). From the analysis of the evolution of the labelled molecules as a function of power, useful information has been obtained about the exchange events of H by D atoms (or vice versa) between the plasma intermediate species. An evaluation of the number of these events revealed a significant progression with the plasma power, a tendency that is recognized to be detrimental for the energy efficiency of reactant to product transformation. The labelling technique is proposed as a useful approach for the analysis of plasma reaction mechanisms

A new roman fish-salting workshop in the Saltes Island (Tinto-Odiel Estuary, SW Spain): La Cascajera and its archaeological and geological context

The southwestern Atlantic coast of the Iberian Peninsula presents an important Roman heritage that includes numerous fish-salting workshops, with an industrial activity that went on for almost a millennium (1st century BC-7th century AD). Nevertheless, a future broad research is still necessary to determine the geologic substratum on which they are based, their palaeoenvironmental evolution, their main economic objectives and the byproducts derived from their activities. This paper is focused on the geology, dating and the archaeological record of La Cascajera, a new site located in the Tinto-Odiel estuary (SW Spain). This new cetaria occupied the northwestern end of La Cascajera ridge (Saltés Island), constituted by sandy, bioclastic deposits of previous washover fans (1st-2th centuries AD). During the main period of activity (middle of 4th century AD-5th century AD), the existence of a certain typology of amphorae as well as the documentation of a shell deposit formed mostly by Glycymeris suggest that this factory was oriented to the production of mixed fish sauces and the handling of edible bivalves. The main features of this deposit (texture, paleontology, taphonomy) could be used to differentiate middens from natural shelly ridges.La costa suratlántica de la Península Ibérica posee un importante legado romano que incluye numerosos talleres halieúticos, con una actividad que se desarrolló durante casi un milenio (siglo I a.C.-siglo VII d.C.). Sin embargo, se precisan nuevas investigaciones que determinen el contexto geológico en el que se desarrollaron, su evolución paleoambiental, sus principales objetivos económicos y los subproductos derivados de sus actividades. Este trabajo se centra en la geología, datación y registro arqueológico de La Cascajera, un nuevo yacimiento localizado en el estuario de los ríos Tinto y Odiel (S.O. de España). Esta nueva cetaria ocupaba el extremo noroccidental de la cresta de La Cascajera (Isla de Saltés), constituida por depósitos bioclásticos arenosos de abanicos de derrame previos (siglos I-II d.C.). Durante su principal periodo de actividad (mitad del siglo IV d.C.-siglo V d.C.), la existencia de una cierta tipología de ánforas así como la existencia de un conchero formado principalmente por Glycymeris sugieren que esta factoría estaba dedicada a la producción de salsas mixtas de pescado y la extracción de bivalvos comestibles. Las principales características de este conchero (textura, paleontología, tafonomía) podrían ser usadas para diferenciar concheros de acumulaciones naturales de conchas.Ministerio de Innovación, Ciencia y Empresa de España. Plan Nacional de I+D+i DEATLANTIR II-HAR2017-89154-PJunta de Andalucía-HUM-132, RNM-238 y RNM-29

Toxoplasma gondii seropositivity associated to peri-urban living places in pregnant women in a rural area of Buenos Aires province, Argentina

Infection with Toxoplasma gondii is very common in humans throughout the world, the intake of raw or undercooked meat with tissue cysts and fruits, vegetables and water contaminated with parasite oocysts being the main routes of infection. Here, we analyzed the seroprevalence of anti-T. gondii antibodies in pregnant females (age 13–44 years; n = 920) between April 2014 and December 2017 from Chascomús (Argentina), a city immersed in a rural area. Altogether 320 tested positive for immunoglobulin G antibodies, yielding an overall seroprevalence of 34.8% (CI 95%: 31.7–37.9). No association was observed between seropositivity and age. In addition, by using the QGIS 3.2.1 software we analyzed the geographical distribution of 769 (83.6%) pregnant females in two main areas of the city: Urban (n = 157) and Peri-urban (n = 612) with a seroprevalence of 26.8% (CI 95%: 19.8–33.7) and 36.4% (CI 95%: 32.6–40.3) respectively, and this difference was statistically significant (p = 0.023). Furthermore, we assessed through a questionnaire survey, between April 2016 to December 2017, possible risk factors such as activity (urban and rural), home water supply, animal husbandry, presence of cats as pets, gardening and consumption of meat and its derivatives (pork, sheep meat and sausages) and their frequencies (consumption per week), not finding significant association with seropositivity. Significant differences was found when the seroprevalence was analyzed between the urban and peri-urban neighborhoods of the city of Chascomús. The higher seroprevalence in peri-urban neighborhoods could be due to an unfavorable socioeconomic situation and/or to undeveloped peri-urban environments, which is a risk factor that should be taken into account when planning the health care of pregnant females.Fil: Rivera, Elias Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Lavayén, Silvina N.. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; ArgentinaFil: Sánchez, Paola. Hospital Municipal de Chascomus San Vicente de Paul; ArgentinaFil: Martins, Carlos M. A.. Hospital Municipal de Chascomus San Vicente de Paul; ArgentinaFil: Gómez, Etelvina. Hospital Municipal de Chascomus San Vicente de Paul; ArgentinaFil: Rodríguez, Jorge P.. Hospital Municipal de Chascomus San Vicente de Paul; ArgentinaFil: Arias, Marcela E.. Secretaría de Salud. Municipalidad de Chascomús; ArgentinaFil: Silva, Andrea Paula. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; ArgentinaFil: Ángel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentin

Modelling the mid-late Holocene evolution of the Huelva Estuary and its human colonization, South-Western Spain

The major changes that occurred in the southwestern estuaries of the Spanish Atlantic coast during the last 6500 yr BP were simultaneous to human settlement and therefore the understanding of their coastal evolution will help interpreting human patterns in these areas. The study of the morpho-sedimentary features of new outcrops appearing in the middle sector of Saltés Island (Huelva Estuary, Spain) has been used to develop a model to understand the complex evolution of sand barriers than can be applied to similar inlets along the Atlantic Iberian coast. The first human settlements (6000–4000 yr BP) in the early Huelva Estuary (Tinto and Odiel rivers) were located in the ancient coastal banks or in the nearby hills. From 4000 yr BP onwards, the estuarine sediments started to emerge as sand barriers and chenier plains, prograding towards the mouth. As the littoral strands stabilized morphologically, they were colonized by human settlements in successive periods, the oldest inland (Almendral) and more recent outward (Cascajera). The study of the upper sedimentary layers of La Cascajera barrier display a tempestitic sequence of landward progradational washover-fans. The calibrated and modelled AMS dates in marine shells provide a storminess time range between the second half of first century BCE and the entire first century CE. Sedimentary records are useful to evaluate environmental changes, either from natural or anthropogenic causes, such as global and climate change. The interrelationship between the archaeological findings (mainly salting fish factories and old ports) and the morpho sedimentary evolution at the mouth of the Tinto and Odiel rivers allows us to highlight not only the Huelva Estuary's dynamics evolution, but also the possible regional patterns of human habitation from the beginning of the present sea-level highstand (middle Holocene).Ministerio de Economía y Competitividad CGL2010-15810/BTEEuropean Union (UE) EU Excellence Project of the Andalusia Board SEJ-477

Photoprotective responses of three intertidal Antarctic macroalgae to short-term temperature stress

The Antarctic Peninsula is experiencing one of the highest warming rates globally. In polar regions, macroalgae thrive under extreme environmental conditions, which could worsen because of future climate change scenarios, including increased ultraviolet exposure, extremely low light availability, and fluctuating temperatures, particularly in the intertidal zones. To investigate the potential role of photoprotective and antioxidant mechanisms in response to future increases in sea surface temperatures caused by climate change, we conducted laboratory experiments using three intertidal macroalgae model species: Adenocystis utricularis (Ochrophyta, Phaeophyceae), Pyropia endiviifolia (Rhodophyta, Bangiophyceae), and Monostroma hariotii (Chlorophyta, Ulvophyceae). These algae were collected in Punta Artigas (King George Island, Antarctica) and acclimated at 2°C for 48 h. They were then assessed in laboratory experiments for up to 5 days under two treatments: (1) control conditions at 2°C and (2) elevated tem.perature conditions at 8°C, representing the most negative increment in SSTs estimated by the end of the 21st century. Carbon, nitrogen, pigments (chlorophylls and carotenoids), mycosporine-like amino acids (MAAs), and phenolic compounds were quantified after 3 and 5 days of exposure. For M. hariotii, elevated temperatures led to an increase in the C/N ratio, total antioxidant capacity, and levels of nitrogen, total carotenoids, chlorophyll-a, pigments (chlorophyll-b and violaxanthin), and phenolic compounds. For A. utricularis, elevated temperatures led to elevated C/N ratio and levels of chlorophyll-a and carotenoids (fucoxanthin and β-carotene). For P. endiviifolia, elevated temperatures resulted in elevated levels of carotenoids (lutein and β-carotene), phenolic compounds, and MAAs (porphyra-334, shinorine, and palythine). Thus, our study suggests that increasing water temperatures due to global warming can enhance the photoprotective abilities of three Antarctic intertidal macroalgae (M. hariotii, A. utricularis, and P. endiviifolia), with each species showing specific responses.Financial and logistical support were granted by the Projects INACH N° RG_10_18 and RT_09_16 granted to PC-P and CS, respectively

Impact of house dust mite-driven asthma on children's school performance and activity

Absenteeism; Allergic asthma; Subcutaneous allergen immunotherapyAbsentisme; Asma al·lèrgica; Immunoteràpia subcutània amb al·lèrgensAbsentismo; Asma alérgica; Inmunoterapia subcutánea con alérgenosEvidence regarding asthma's impact on children's daily lives is limited. This prospective and cross-sectional, observational, multicenter study assessed school/work and activity impairment in children and adolescents with allergic asthma and their caregivers and allergen immunotherapy (AIT) effects. Included patients were schooled children and adolescents (5 to 17 years) with allergic asthma due to house dust mites (HDM). Impairment of school/work (i.e., absenteeism and presenteeism) and activity was measured in patients and their caregivers using the Work Productivity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific (WPAI + CIQ:AS). HDM allergic patients with school impairment received subcutaneous AIT with a MicroCrystalline Tyrosine-associated allergoid. WPAI + CIQ:AS and effectiveness variables were compared between baseline and 1-year post-AIT. Of the 113 patients included, 59 (52.2%) and 51 (45.1%) showed school and activity impairment, respectively, missing a mean (SD) of 37.6 (24.4) % and 42.6 (25.6) % of school and activity time, respectively. Twenty-six (23%) caregivers reported activity impairment and, of the 79 (69.9%) employed, 30 (38%) reported work impairment. Of the 65 patients with school/activities impairment, 41 (63.1%) received AIT, of which 21 (51.2%) completed 1 year of treatment. Effectiveness variables and WPAI + CIQ:AS significantly improved: Mean (SD) school impairment decreased from 39.7 (26.7) to 2.1 (7.1) % (p < 0.001) and activity impairment from 46.2 (34.6) to 1.4 (3.6) % (p < 0.001). Conclusion: Allergic asthma due to HDMs results in school/work and activity impairment in children and adolescents and their caregivers. One year of AIT provided clinical benefits and reduced school and activity impairment. What is known: • Allergic asthma impairs children's school performance and daily activities. • Allergen immunotherapy modifies allergic disease course and ameliorates its symptoms. What is new: • Asthma symptoms due to allergy to house dust mites impair children's school attendance and productivity and daily activity and their caregivers' work performance and daily lives. • Allergen immunotherapy with a house dust mite MicroCrystalline Tyrosine (MCT)-associated allergoid seems to provide clinical benefits, associated with decreased school and activity impairment, supporting it as an effective treatment option

Diagnostico del Impacto del Palangre de Fondo en los Hábitats Bentónicos en los LICs de la RN20000

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MAPK Pathway under Chronic Copper Excess in Green Macroalgae (Chlorophyta): Influence on Metal Exclusion/Extrusion Mechanisms and Photosynthesis

There is currently no information regarding the role that whole mitogen activated protein kinase (MAPK) pathways play in counteracting environmental stress in photosynthetic organisms. To address this gap, we exposed Ulva compressa to chronic levels of copper (10 µM) specific inhibitors of Extracellular Signal Regulated Kinases (ERK), c-Jun N-terminal Kinases (JNK), and Cytokinin Specific Binding Protein (p38) MAPKs alone or in combination. Intracellular copper accumulation and photosynthetic activity (in vivo chlorophyll a fluorescence) were measured after 6 h, 24 h, 48 h, and 6 days of exposure. By day 6, when one (except JNK) or more of the MAPK pathways were inhibited under copper stress, there was a decrease in copper accumulation compared with algae exposed to copper alone. When at least two MAPKs were blocked, there was a decrease in photosynthetic activity expressed in lower productivity (ETRmax), efficiency (αETR), and saturation of irradiance (EkETR), accompanied by higher non-photochemical quenching (NPQmax), compared to both the control and copper-only treatments. In terms of accumulation, once the MAPK pathways were partially or completely blocked under copper, there was crosstalk between these and other signaling mechanisms to enhance metal extrusion/exclusion from cells. Crosstalk occurred among MAPK pathways to maintain photosynthesis homeostasis, demonstrating the importance of the signaling pathways for physiological performance. This study is complemented by a parallel/complementary article Rodríguez-Rojas et al. on the role of MAPKs in copper-detoxification.</jats:p