Fortalecimiento Institucional mediante alianzas para la mitigación del desempleo de Engativá: desde un enfoque territorial

Fortalecer la Oficina de Planeación de la Alcaldía Local de Engativá, mediante la herramienta de la gerencia social, alianzas, con validación de grupos focales, para generar una estrategia que contribuya a la mitigación del desempleo y permita ampliar la accesibilidad al mercado laboral de los habitantes de la localidad de Engativá de Bogotá D.C. durante el 2021- 2024, desde un enfoque territorial.Según la Alcaldía Mayor de Bogotá (2020), las cifras presentadas por el DANE en 2017 reflejan que el desempleo en la localidad de Engativá es considerablemente alto (entre 7,2 % y 8,6 %) en comparación a sus vecinos limítrofes (Teusaquillo menos del 4,1% y Barrios Unidos, Fontibón y Suba entre 4,2% y 7,1%). Desde este contexto, se propone a la Alcaldía Local de Engativá, la implementación de alianzas, desde un enfoque territorial, que impacte a la población con mayores dificultades de empleabilidad, en particular, las personas con mayores desventajas sociales y económicas, para que puedan acceder al mercado laboral de su propia localidad, contribuyendo así a disminuir su tiempo en transporte casa-trabajo, e incrementar su tiempo libre para actividades académicas, familiares, personales y/o de ocio y recreación, lo cual se refleja en el mejoramiento de su calidad de vida. Para la validación de esta propuesta, se desarrollaron grupos focales con los aliados propuestos, la comunidad y un grupo de expertos.According to Mayor’s Office of Bogotá (2020), the figures presented by DANE in 2017, reflect that unemployment in the town of Engativá is considerably high (between 7.2% and 8.6%) compared to its neighboring towns (Teusaquillo less than 4.1% and Barrios Unidos, Fontibón and Suba between 4.2% and 7.1%). In that context, it is proposed to the Engativá Local Mayor’s Office, to implement alliances, since a territorial approach, to impact the population who has greater employability difficulties, particularly people with greater social and economic disadvantages, so that they can access the labor market of their own locality. By doing so, this would contribute to reducing their time in commuting home-to-work, and increasing their free time for academic, family, personal and / or leisure activities and recreation, which is reflected in the improvement of their life quality. For the validation of this proposal, focus groups were developed with the partners involved, the community, and a group of experts

Fortalecimiento Institucional mediante alianzas para la mitigación del desempleo de Engativá: desde un enfoque territorial

Fortalecer la Oficina de Planeación de la Alcaldía Local de Engativá, mediante la herramienta de la gerencia social, alianzas, con validación de grupos focales, para generar una estrategia que contribuya a la mitigación del desempleo y permita ampliar la accesibilidad al mercado laboral de los habitantes de la localidad de Engativá de Bogotá D.C. durante el 2021- 2024, desde un enfoque territorial.Según la Alcaldía Mayor de Bogotá (2020), las cifras presentadas por el DANE en 2017 reflejan que el desempleo en la localidad de Engativá es considerablemente alto (entre 7,2 % y 8,6 %) en comparación a sus vecinos limítrofes (Teusaquillo menos del 4,1% y Barrios Unidos, Fontibón y Suba entre 4,2% y 7,1%). Desde este contexto, se propone a la Alcaldía Local de Engativá, la implementación de alianzas, desde un enfoque territorial, que impacte a la población con mayores dificultades de empleabilidad, en particular, las personas con mayores desventajas sociales y económicas, para que puedan acceder al mercado laboral de su propia localidad, contribuyendo así a disminuir su tiempo en transporte casa-trabajo, e incrementar su tiempo libre para actividades académicas, familiares, personales y/o de ocio y recreación, lo cual se refleja en el mejoramiento de su calidad de vida. Para la validación de esta propuesta, se desarrollaron grupos focales con los aliados propuestos, la comunidad y un grupo de expertos.According to Mayor’s Office of Bogotá (2020), the figures presented by DANE in 2017, reflect that unemployment in the town of Engativá is considerably high (between 7.2% and 8.6%) compared to its neighboring towns (Teusaquillo less than 4.1% and Barrios Unidos, Fontibón and Suba between 4.2% and 7.1%). In that context, it is proposed to the Engativá Local Mayor’s Office, to implement alliances, since a territorial approach, to impact the population who has greater employability difficulties, particularly people with greater social and economic disadvantages, so that they can access the labor market of their own locality. By doing so, this would contribute to reducing their time in commuting home-to-work, and increasing their free time for academic, family, personal and / or leisure activities and recreation, which is reflected in the improvement of their life quality. For the validation of this proposal, focus groups were developed with the partners involved, the community, and a group of experts

Análisis de los aspectos sociales y ambientales que intervienen en la gestión integral de los residuos sólidos domiciliarios del barrio “La Salina”, localidad de Engativá, Bogotá D.C. una visión desde la gerencia social.

Elaborar un análisis de los aspectos sociales y ambientales que intervienen en la gestión integral de los residuos sólidos domiciliarios del barrio “La Salina”, localidad de Engativá, Bogotá D.C. que permita la definición de acciones que mejoren las prácticas existentes.La generación y manejo de los residuos sólidos cobra un papel importante en la sostenibilidad y sustentabilidad del planeta, motivo por el cual se han creado políticas públicas, planes y proyectos orientados a su adecuado manejo y enfocados en los objetivos de desarrollo sostenible en especial el que se orienta al consumo responsable puesto que el impacto ambiental que se genera es significativo y afecta enormemente la calidad de vida de las comunidades.The waste generation and management take an important role in sustainability of the World. For this, public policies, plans and projects have been created to promote correct solid wasted management, inspired by Sustainable Development Goals, specially, responsible consumption and production as an answer to the environmental impact generated that affect significantly the community life quality. The objective of this investigation is elaborate an analysis of the social and environmental aspects that intervene in the integrated management of domestic solid waste of the neighborhood “La Salina”, location Engativá, Bogotá D.C. in a way that allows to define actions that improve the existed practices; a study is implement from home surveys and actors involved interviews about the process of waste management and its disposal. As result, it is evident that indispensable factors for proper separation at the source and correct waste management are related to education and knowledge provided to the community about this topic as responsible consumption; likewise, the consolidation of recycling routes and the monitoring of the training processes carried out by the competent public entities and cleaning operators play an essential role. Keeping this in mind, the creation of the recycling route for "La Salina" neighborhood is recommended as it does not exist at present, and workshops and training should be generated through the creation of strategic networks between public and private entities that allow strengthening the knowledge of the community regarding the issue; however, these processes would not achieve the appropriate impact until a District public policy of integrated management of solid household waste is formulated in accordance with the national policy that allows land strategies and proposals

Análisis de los aspectos sociales y ambientales que intervienen en la gestión integral de los residuos sólidos domiciliarios del barrio “La Salina”, localidad de Engativá, Bogotá D.C. una visión desde la gerencia social.

Elaborar un análisis de los aspectos sociales y ambientales que intervienen en la gestión integral de los residuos sólidos domiciliarios del barrio “La Salina”, localidad de Engativá, Bogotá D.C. que permita la definición de acciones que mejoren las prácticas existentes.La generación y manejo de los residuos sólidos cobra un papel importante en la sostenibilidad y sustentabilidad del planeta, motivo por el cual se han creado políticas públicas, planes y proyectos orientados a su adecuado manejo y enfocados en los objetivos de desarrollo sostenible en especial el que se orienta al consumo responsable puesto que el impacto ambiental que se genera es significativo y afecta enormemente la calidad de vida de las comunidades.The waste generation and management take an important role in sustainability of the World. For this, public policies, plans and projects have been created to promote correct solid wasted management, inspired by Sustainable Development Goals, specially, responsible consumption and production as an answer to the environmental impact generated that affect significantly the community life quality. The objective of this investigation is elaborate an analysis of the social and environmental aspects that intervene in the integrated management of domestic solid waste of the neighborhood “La Salina”, location Engativá, Bogotá D.C. in a way that allows to define actions that improve the existed practices; a study is implement from home surveys and actors involved interviews about the process of waste management and its disposal. As result, it is evident that indispensable factors for proper separation at the source and correct waste management are related to education and knowledge provided to the community about this topic as responsible consumption; likewise, the consolidation of recycling routes and the monitoring of the training processes carried out by the competent public entities and cleaning operators play an essential role. Keeping this in mind, the creation of the recycling route for "La Salina" neighborhood is recommended as it does not exist at present, and workshops and training should be generated through the creation of strategic networks between public and private entities that allow strengthening the knowledge of the community regarding the issue; however, these processes would not achieve the appropriate impact until a District public policy of integrated management of solid household waste is formulated in accordance with the national policy that allows land strategies and proposals

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Hypermethylation of HOOK2 gene and its relation with Type 2 diabetes susceptibility in individuals with obesity

Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D). More than 485,000 CpG genome sites from visceral adipose tissue samples from women with obesity undergoing gastric bypass (n=18), and classified as suffering from type 2 diabetes or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays