Emilio Gutiérrez de Quintanilla: Entre la tradición y la modernidad

El documento digital no refiere asesorPublicación a texto completo no autorizada por el autorManifiesta que el objeto de estudio es tanto la obra como el autor; Emilio Gutiérrez de Quintanilla y su tránsito entre la tradición y la modernidad, su predilección por el arte desde la perspectiva teórica e histórica, la crítica y hasta la práctica. Produjo gran cantidad de artículos, conferencias, ensayos, crítica de arte, durante su vida: desde la década de 1880 y su primer aporte; la traducción del libro de J. Proudhon, El arte y su destino social, hasta sus libros de compilaciones de ensayos y conferencias correspondientes a la década de 1920. La investigación comprende el análisis general de los textos, artículos de diferentes publicaciones periódicas, ensayos, conferencias y reseñas con un motivo en común; el arte; gracias al método histórico crítico que hemos aplicado, se podrá relacionar dicha producción con el autor y su contexto y reconocer sus caracteres, bien modernos o bien tradicionales.Tesi

Electrical monitoring of infection biomarkers in chronic wounds using nanochannels

Chronic wounds represent an important healthcare challenge in developed countries, being wound infection a serious complication with significant impact on patients’ life conditions. However, there is a lack of methods allowing an early diagnosis of infection and a right decision making for a correct treatment. In this context, we propose a novel methodology for the electrical monitoring of infection biomarkers in chronic wound exudates, using nanoporous alumina membranes. Lysozyme, an enzyme produced by the human immune system indicating wound infection, is selected as a model compound to prove the concept. Peptidoglycan, a component of the bacterial layer and the native substrate of lysozyme, is immobilized on the inner walls of the nanochannels, blocking them both sterically and electrostatically. The steric blocking is dependent on the pore size (20 - 100 nm) and the peptidoglycan concentration, whereas the electrostatic blocking depends on the pH. The proposed analytical method is based on the electrical monitoring of the steric/electrostatic nanochannels unblocking upon the specific degradation of peptidoglycan by lysozyme, allowing to detect the infection biomarker at 280 ng/mL levels, which are below those expected in wounds. The low protein adsorption rate and thus outstanding filtering properties of the nanoporous alumina membranes allowed us to discriminate wound exudates from patients with both sterile and infected ulcers without any sample pre-treatment usually indispensable in most diagnostic devices for analysis of physiological fluids. Although size and charge effects in nanochannels have been previously approached for biosensing purposes, as far as we know, the use of nanoporous membranes for monitoring enzymatic cleavage processes, leading to analytical systems for the specific detection of the enzymes has not been deeply explored so far. Compared with previously reported methods, our methodology presents the advantages of no need of neither bioreceptors (antibodies or aptamers) nor competitive assays, low matrix effects and quantitative and rapid analysis at the point-of-care, being also of potential application for the determination of other protease biomarkers.Peer ReviewedPostprint (published version

Health-related lifestyles and cancer-preventive behaviors of medical and nursing students and family medicine residents in relation to the European Code Against Cancer.

Background: Family medicine (FM) residents and medical and nursing students play an important role in the development of preventive and health-promoting activities. Objective: To evaluate the health-related lifestyles and cancer-preventive behaviors of medical and nursing students and FM residents in relation to the European Code Against Cancer (ECAC). Methods: This was a descriptive, cross-sectional study performed in Spain. Medical and nursing students, and FM residents completed a self-administered questionnaire focused on health-related habits and clinical behaviors related to the ECAC. Results: A total of 740 participants completed the questionnaire. 12.2% (95% CI [9.8–14.5]) were smokers and 77.3% (95% CI [74.3–80.3]) sporadically consumed alcohol; 34.2% (95% CI [30.8–37.6]) practiced physical activity 2–3 times a week, and 12.1% (95% CI [9.8–14.5]) were overweight or obese. 54.2% (95% CI [50.6–57.8]) regularly consumed vegetables. Differences were detected in the completion of screening tests for colorectal cancer (p < 0.001), breast cancer (p = 0.023), cervical cancer (p = 0.006), and prostate-specific antigen determination (p < 0.001) in relation to the participants’ academic profiles. Conclusion: Our results reveal heterogeneous practices between the participants in terms of health-related habits. Awareness about the risks of smoking and being overweight were high, however, the perception of the risks associated with solar exposure and alcohol consumption was poor. There was general agreement upon the importance of performing screening tests for breast, cervical, and colorectal cancer, but there were discrepancies related to the need to perform the prostate cancer screening test.pre-print322 K

El Discurso sobre arte de Sebastián Salazar Bondy. El tacto imperceptible

El presente estudio es resultado, a través de la revisión continua, de la revelación y el descubrimiento de los finos límites que definen las nociones básicas en el discurso sobre arte de Sebastián Salazar Bondy (Lima, 1924 1965). Límites conceptuales que se entrecruzan, se difuminan, se tornan complejos, volviendo a su vez compleja la comprensión total del sentido del discurso en su integridad. En este trabajo nos proponemos esclarecer aquellos límites para su comprensión más cabal. Nuestro objetivo final es demarcar los lineamientos conceptuales del discurso, exponiéndolos de modo coherente, dentro de las 5 posibilidades interpretativas que ofrece el autor. Nótese que nuestras fuentes primarias son los escritos del autor que, publicados en diversos libros, periódicos y revistas, no pertenecen a un texto orgánico.Tesi