Additional file 1: of Real-life clinical practice results with vinflunine in patients with relapsed platinum-treated metastatic urothelial carcinoma: an Italian multicenter study (MOVIE-GOIRC 01–2014)

List of participating centers. Table S1. Stratified analysis of overall survival (OS) and progression-free survival (PFS) according to previous Cisplatin or Carboplatin treatment and to the number of cycles received. (DOCX 46 kb

Tumor Staining Characteristics.

<p>*IHC = immunohistochemistry.</p>†<p>ISH = in situ hybridization.</p>‡<p>Staining extent is defined within the “<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095724#s2" target="_blank">Methods</a>” section of the text.</p

The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder - Figure 3

<p>One additional case of primary adenocarcinoma of the urinary bladder (pT3) is highly infiltrative with some mucinous features on H&E (A). p16 shows strong nuclear and cytoplasmic reactivity in a majority of cells, but there is some variability in the staining (B). No reactivity is seen with either p53 (C) or HPV (D) immunostains in this case. Controls for HPV immunohistochemistry (E) and in situ hybridization (F) are demonstrated here.</p

Tumor Classification by Stage (n = 36).

<p>*Diagnosis of stage pT3 or pT4 disease is not possible on these types of specimens</p