The Effects of a Progressive Exercise Program on Functional Activity and Quality of Life for Older Overweight Women with Knee Osteoarthritis

Background and Purpose Osteoarthritis (OA) is a common symptomatic condition experienced by older adults, especially in the overweight population, that affects the knees in particular. This study compares the effectiveness of two progressive exercise protocols (walking and stepping) on function and quality of life in older, overweight women with OA. This study includes self-management training and assesses participant selfperceived efficacy in managing OA. Subjects This is a quasi-experimental design utilizing 16 women ≥ 50 years of age (60.44 ± 6.04) with a BMI \u3e 25 (34.21 ± 7.28) and radiographic diagnosis of OA in at least one knee. Methods and Measures Subjects were randomly assigned to a protocol group and followed exercises twice per week with supervision and once per week independently during the 10-week study. Pre and post-tests were performed using NeuroCom Smart Equitest, Dualenergy X-ray Absorptiometry (DEXA) scan, pain visual analog scale, isometric strength, and self-reported outcome measures including; Knee Osteoarthritis Outcomes Score (KOOS), CDC HRQOL-14 “Healthy Days Measure” - Quality of Life (QOL), and the Patient Activity Measure (PAM). Results The walking group showed significant improvement in the KOOS -QOL (p=0.026) and function (p=0.027) subscales as well as the NeuroCom Sensory Organization Test (SOT) (p=0.022). No significant results were found within the stepping group. Groups were combined and significant results were found in the KOOS- QOL (p=0.022), NeuroCom SOT (0.001), and NeuroCom Limits of Stability (LOS) (p=0.024). Conclusion A simple 10 week walking exercise incorporating self-management is shown to improve function, quality of life, and balance. The stepping exercise did not show any significant improvement. However, when the 2 groups are combined, we observed similar improvement in the 3 aforementioned domains. The results from this research provide important insights into exercise intervention in older overweight women with knee OA

Assessment of ethanol and nicotine interactions using a reinforcer demand modeling with grouped and individual levels of analyses in a long-access self-administration model using male rats

Previous reports have indicated the reciprocal effects of nicotine and ethanol on their rewarding and reinforcing properties, but studies using methodological approaches resembling substance use in vulnerable populations are lacking. In our study, rats first self-administered ethanol, and their sensitivity to ethanol’s reinforcing effects was assessed using a reinforcer demand modeling approach. Subsequently, rats were equipped with intravenous catheters to self-administer nicotine, and their sensitivity to nicotine’s reinforcing effects was evaluated using the same approach. In the final phase, rats were allowed to self-administer ethanol and nicotine concurrently, investigating the influence of one substance on the rate of responding for the other substance. Group analyses revealed notable differences in demand among sucrose, sweetened ethanol, and ethanolalone, with sucrose demonstrating the highest demand and ethanol-alone exhibiting greater sensitivity to changes in cost. At the individual level, our study finds significant correlations between rats’ demand for sucrose and sweetened ethanol, suggesting parallel efforts for both substances. Our individual data also suggest interconnections in the elasticity of demand for sweetened ethanol and ethanol-alone, as well as a potential relationship in price response patterns between ethanol and nicotine. Furthermore, concurrent self-administration of ethanol and nicotine at the group level displayed reciprocal effects, with reduced responding for nicotine in the presence of ethanol and increased responding for ethanol in the presence of nicotine. This study provides valuable insights into modeling the co-use of ethanol and nicotine and assessing their interaction effects using reinforcer demand modeling and concurrent self-administration or noncontingent administration tests. These findings contribute to our understanding of the complex interplay between ethanol and nicotine and have implications for elucidating the underlying mechanisms involved in polydrug use

The vertical distribution and biological transport of marine microplastics across the epipelagic and mesopelagic water column.

Plastic waste has been documented in nearly all types of marine environments and has been found in species spanning all levels of marine food webs. Within these marine environments, deep pelagic waters encompass the largest ecosystems on Earth. We lack a comprehensive understanding of the concentrations, cycling, and fate of plastic waste in sub-surface waters, constraining our ability to implement effective, large-scale policy and conservation strategies. We used remotely operated vehicles and engineered purpose-built samplers to collect and examine the distribution of microplastics in the Monterey Bay pelagic ecosystem at water column depths ranging from 5 to 1000 m. Laser Raman spectroscopy was used to identify microplastic particles collected from throughout the deep pelagic water column, with the highest concentrations present at depths between 200 and 600 m. Examination of two abundant particle feeders in this ecosystem, pelagic red crabs (Pleuroncodes planipes) and giant larvaceans (Bathochordaeus stygius), showed that microplastic particles readily flow from the environment into coupled water column and seafloor food webs. Our findings suggest that one of the largest and currently underappreciated reservoirs of marine microplastics may be contained within the water column and animal communities of the deep sea

EEFlux: A Landsat-based Evapotranspiration mapping tool on the Google Earth Engine

“EEFlux” is an acronym for ‘Earth Engine Evapotranspiration Flux.’ EEFlux is based on the operational surface energy balance model “METRIC” (Mapping ET at high Resolution with Internalized Calibration), and is a Landsat-imagebased process. Landsat imagery supports the production of ET maps at resolutions of 30 m, which is the scale of many human-impacted and human-interest activities including agricultural fields, forest clearcuts and vegetation systems along streams. ET over extended time periods provides valuable information regarding impacts of water consumption on Earth resources and on humans. EEFlux uses North American Land Data Assimilation System hourly gridded weather data collection for energy balance calibration and time integration of ET. Reference ET is calculated using the ASCE (2005) Penman-Monteith and GridMET weather data sets. The Statsgo soil data base of the USDA provides soil type information. EEFlux will be freely available to the public and includes a web-based operating console. This work has been supported by Google, Inc. and is possible due to the free Landsat image access afforded by the USGS

Author Correction: The vertical distribution and biological transport of marine microplastics across the epipelagic and mesopelagic water column.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Effects of d-α-Tocopherol and Dietary Energy on Growth and Health of Pre-Ruminant Dairy Calves

Newborn Holstein bull calves were fed milk to support low or moderate growth and were supplemented with a complement of vitamins A, D, and E. The objective of the study was to determine the effects of dietary energy and vitamin supplementation on inflammation at the whole-body level. Calves were assigned randomly to one of four treatment groups (low growth, not vitamin supplemented; low growth, vitamin supplemented; moderate growth, not vitamin supplemented; moderate growth, vitamin supplemented) for five weeks. Vitamin supplementation tended to improve average daily gain in moderate-growth calves and significantly increased concentrations of retinol, 25-(OH)-vitamin D, and α-tocopherol in plasma in supplemented groups. Moderate growth calves exhibited lower concentrations of α-tocopherol in plasma and higher concentrations of serum haptoglobin, which is a protein associated with chronic inflammation. All calves exhibited elevated concentrations of the more acute indicator of inflammation, serum amyloid A, during weeks 1-3. These results indicate potential roles for vitamins A, D, and E in moderation of pro-inflammatory responses early in life

Limits on Gravitational-Wave Emission from Selected Pulsars Using LIGO Data

We place direct upper limits on the amplitude of gravitational waves from 28 isolated radio pulsars by a coherent multidetector analysis of the data collected during the second science run of the LIGO interferometric detectors. These are the first direct upper limits for 26 of the 28 pulsars. We use coordinated radio observations for the first time to build radio-guided phase templates for the expected gravitational-wave signals. The unprecedented sensitivity of the detectors allows us to set strain upper limits as low as a few times 10^(-24). These strain limits translate into limits on the equatorial ellipticities of the pulsars, which are smaller than 10^(-5) for the four closest pulsars

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

Upper limits on the strength of periodic gravitational waves from PSR J1939+2134

The first science run of the LIGO and GEO gravitational wave detectors presented the opportunity to test methods of searching for gravitational waves from known pulsars. Here we present new direct upper limits on the strength of waves from the pulsar PSR J1939+2134 using two independent analysis methods, one in the frequency domain using frequentist statistics and one in the time domain using Bayesian inference. Both methods show that the strain amplitude at Earth from this pulsar is less than a few times $10^{-22}$.Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July 200