"The Jester and the sage"

Though Mark Twain and Friedrich Nietzsche were aware of each other, they never met and there is no evidence of influence in either direction. Yet the similarities in their thought are strikingly numerous and close. They were both penetrating psychologists who shared Sigmund Freud's interest in the unconscious and his misgiving about the future of civilization. Both regarded Christianity as a leading symptom of the world's madness, manifest in a slavish morality of good and evil and in a widespread subjection to irrational guilt. They were at one in lamenting the pervasive human surrender to varieties of evasion, disavowel, deceit, and self-deception. Other, lesser similarities abound in thought, style, and patterns of literary production. © 2005 by The Regents of the University of California

Dynamical aspects of mean field plane rotators and the Kuramoto model

The Kuramoto model has been introduced in order to describe synchronization phenomena observed in groups of cells, individuals, circuits, etc... We look at the Kuramoto model with white noise forces: in mathematical terms it is a set of N oscillators, each driven by an independent Brownian motion with a constant drift, that is each oscillator has its own frequency, which, in general, changes from one oscillator to another (these frequencies are usually taken to be random and they may be viewed as a quenched disorder). The interactions between oscillators are of long range type (mean field). We review some results on the Kuramoto model from a statistical mechanics standpoint: we give in particular necessary and sufficient conditions for reversibility and we point out a formal analogy, in the N to infinity limit, with local mean field models with conservative dynamics (an analogy that is exploited to identify in particular a Lyapunov functional in the reversible set-up). We then focus on the reversible Kuramoto model with sinusoidal interactions in the N to infinity limit and analyze the stability of the non-trivial stationary profiles arising when the interaction parameter K is larger than its critical value K_c. We provide an analysis of the linear operator describing the time evolution in a neighborhood of the synchronized profile: we exhibit a Hilbert space in which this operator has a self-adjoint extension and we establish, as our main result, a spectral gap inequality for every K>K_c.Comment: 18 pages, 1 figur

A Circulating Hydrogen Ultra-High Purification System for the MuCap Experiment

The MuCap experiment is a high-precision measurement of the rate for the basic electroweak process of muon capture, mu- + p -> n + nu . The experimental approach is based on an active target consisting of a time projection chamber (TPC) operating with pure hydrogen gas. The hydrogen has to be kept extremely pure and at a stable pressure. A Circulating Hydrogen Ultrahigh Purification System was designed at the Petersburg Nuclear Physics Institute (PNPI) to continuously clean the hydrogen from impurities. The system is based on an adsorption cryopump to stimulate the hydrogen flow and on a cold adsorbent for the hydrogen cleaning. It was installed at the Paul Scherrer Institute (PSI) in 2004 and performed reliably during three experiment runs. During several months long operating periods the system maintained the hydrogen purity in the detector on the level of 20 ppb for moisture, which is the main contaminant, and of better than 7 ppb and 5 ppb for nitrogen and oxygen, respectively. The pressure inside the TPC was stabilized to within 0.024% of 10 bar at a hydrogen flow rate of 3 standard liters per minute.Comment: submitted to Nucl. Instr. Methods Phys. Res.

On the `Stationary Implies Axisymmetric' Theorem for Extremal Black Holes in Higher Dimensions

All known stationary black hole solutions in higher dimensions possess additional rotational symmetries in addition to the stationary Killing field. Also, for all known stationary solutions, the event horizon is a Killing horizon, and the surface gravity is constant. In the case of non-degenerate horizons (non-extremal black holes), a general theorem was previously established [gr-qc/0605106] proving that these statements are in fact generally true under the assumption that the spacetime is analytic, and that the metric satisfies Einstein's equation. Here, we extend the analysis to the case of degenerate (extremal) black holes. It is shown that the theorem still holds true if the vector of angular velocities of the horizon satisfies a certain "diophantine condition," which holds except for a set of measure zero.Comment: 30pp, Latex, no figure

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We found that VCP/p97 was tied to multiple metabolic processes on the gene expression level in a diverse range of cancer cell lines and in patient-derived multiple myeloma cells. Cellular VCP/p97 dependency to maintain proteostasis was increased under conditions of glucose and glutamine limitation in a range of cancer cell lines from different tissues. Moreover, glutamine depletion led to increased VCP/p97 expression, whereas VCP/p97 inhibition perturbed metabolic processes and intracellular amino acid turnover. GCN2, an amino acid-sensing kinase, attenuated stress signalling and cell death triggered by VCP/p97 inhibition and nutrient shortages and modulated ERK activation, autophagy, and glycolytic metabolite turnover. Together, our data point to an interconnected role of VCP/p97 and GCN2 in maintaining cancer cell metabolic and protein homoeostasis

Determinants of international students' academic performance: A comparison between Chinese and other international students

With the increasing number of international students travelling to well-developed countries for higher education, there has been a growing interest in exploring the factors that influence their academic performance during their overseas studies. This study aims to give an insight into international students' learning experience by investigating the differences between Chinese and non-Chinese cultural groups and leads to the identification of the key predictors of their academic achievement via multiple regression analysis. The results suggest that the perceived importance of learning success to family, English writing ability, and social communication with their compatriots are significant predictors for all international students. As the predominant group, Chinese students display some distinctive characteristics. A less active learning strategy is observed among Chinese students relative to others, but no evidence has found that this negatively affects their academic achievement. © 2010 Nuffic

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.

UNLABELLED: Glioblastoma (GBM) is the most aggressive human brain tumor. Although several molecular subtypes of GBM are recognized, a robust molecular prognostic marker has yet to be identified. Here, we report that the stemness regulator Sox2 is a new, clinically important target of microRNA-21 (miR-21) in GBM, with implications for prognosis. Using the MiR-21-Sox2 regulatory axis, approximately half of all GBM tumors present in the Cancer Genome Atlas (TCGA) and in-house patient databases can be mathematically classified into high miR-21/low Sox2 (Class A) or low miR-21/high Sox2 (Class B) subtypes. This classification reflects phenotypically and molecularly distinct characteristics and is not captured by existing classifications. Supporting the distinct nature of the subtypes, gene set enrichment analysis of the TCGA dataset predicted that Class A and Class B tumors were significantly involved in immune/inflammatory response and in chromosome organization and nervous system development, respectively. Patients with Class B tumors had longer overall survival than those with Class A tumors. Analysis of both databases indicated that the Class A/Class B classification is a better predictor of patient survival than currently used parameters. Further, manipulation of MiR-21-Sox2 levels in orthotopic mouse models supported the longer survival of the Class B subtype. The MiR-21-Sox2 association was also found in mouse neural stem cells and in the mouse brain at different developmental stages, suggesting a role in normal development. Therefore, this mechanism-based classification suggests the presence of two distinct populations of GBM patients with distinguishable phenotypic characteristics and clinical outcomes. SIGNIFICANCE STATEMENT: Molecular profiling-based classification of glioblastoma (GBM) into four subtypes has substantially increased our understanding of the biology of the disease and has pointed to the heterogeneous nature of GBM. However, this classification is not mechanism based and its prognostic value is limited. Here, we identify a new mechanism in GBM (the miR-21-Sox2 axis) that can classify ∼50% of patients into two subtypes with distinct molecular, radiological, and pathological characteristics. Importantly, this classification can predict patient survival better than the currently used parameters. Further, analysis of the miR-21-Sox2 relationship in mouse neural stem cells and in the mouse brain at different developmental stages indicates that miR-21 and Sox2 are predominantly expressed in mutually exclusive patterns, suggesting a role in normal neural development

Peri-Pregnancy Cannabis Use and Autism Spectrum Disorder in the Offspring: Findings from the Study to Explore Early Development

The association of autism spectrum disorder (ASD) with self-reported maternal cannabis use from 3 months pre-conception to delivery (“peri-pregnancy”) was assessed in children aged 30–68 months, born 2003 to 2011. Children with ASD (N = 1428) were compared to children with other developmental delays/disorders (DD, N = 1198) and population controls (POP, N = 1628). Peri-pregnancy cannabis use was reported for 5.2% of ASD, 3.2% of DD and 4.4% of POP children. Adjusted odds of peri-pregnancy cannabis use did not differ significantly between ASD cases and DD or POP controls. Results were similar for any use during pregnancy. However, given potential risks suggested by underlying neurobiology and animal models, further studies in more recent cohorts, in which cannabis use and perception may have changed, are needed