Applying coupon-collecting theory to computer-aided assessments

Computer-based tests with randomly generated questions allow a large number of different tests to be generated. Given a fixed number of alternatives for each question, the number of tests that need to be generated before all possible questions have appeared is surprisingly low.Comment: 19 pages; bibliographic information added as follows. To appear in Bingham, N. H., and Goldie, C. M. (eds), Probability and Mathematical Genetics: Papers in Honour of Sir John Kingman. London Math. Soc. Lecture Note Series. Cambridge: Cambridge Univ. Pres

Identifying what makes a good question in a mechanics diagnostic test

Many students entering engineering degrees encounter problems with the mathematics involved. More recently, research has shown that freshers may have insuffi cient knowledge of mechanics. In order to assess this, the authors created and administered a multiple-choice mechanics diagnostic test. This paper gives details of the test, and evaluates, using item analysis, how students performed on the questions and on the topics assessed by it. It also makes recommendations for devising questions which allow a diagnostic test to discriminate between students

Engineering students understanding mathematics (ESUM): research rigour and dissemination

The Engineering Students Understanding Mathematics (ESUM) project was a developmental research project aimed at enhancing the quality of mathematics learning of students of materials engineering in terms of their engagement and conceptual understanding. The initial phase of the project consisted of an innovation in mathematics teaching-learning which was designed, implemented and studied, with feedback and concomitant modification to practice. Details are reported in Jaworski (2011b). The second phase of the project, reported here, focused more overtly on the analysis of data in relation to theoretical perspectives. In particular, Activity Theory (AT) was used to make sense of emerging findings. A literature review was undertaken and showed evidence of so-called ‘constructivist’ methods being introduced to the teaching of mathematics in higher education (HE). Dissemination has taken place both internally within the institution and externally and is still ongoing. It has generated interest and activity beyond the local setting. Findings from the project include students’ views on elements of the innovation, improved scores on tests and examinations compared with earlier cohorts and students’ strategic approaches to their studies and ways in which this creates tensions with lecturers’ aims in designing the innovatory approach. The gains from the projects can be seen in terms of developing knowledge of the complexities of achieving principles for more conceptual understandings of mathematics within the context and culture in which teaching and learning take place

Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

Centrins are calmodulin-like proteins present in centrosomes and yeast spindle pole bodies (SPBs) and have essential functions in their duplication. The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled. The crystal structures of Sfi1p–centrin complexes containing several repeats show Sfi1p as an α helix with centrins wrapped around each repeat and similar centrin–centrin contacts between each repeat. Electron microscopy (EM) shadowing of an Sfi1p–centrin complex with 15 Sfi1 repeats and 15 centrins bound showed filaments 60 nm long, compatible with all the Sfi1 repeats as a continuous α helix. Immuno-EM localization of the Sfi1p N and C termini showed Sfi1p–centrin filaments spanning the length of the half-bridge with the Sfi1p N terminus at the SPB. This suggests a model for SPB duplication where the half-bridge doubles in length by association of the Sfi1p C termini, thereby providing a new Sfi1p N terminus to initiate SPB assembly

Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS)

Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care. Methods: Two population-based studies of older people in defined geographical areas conducted two decades apart (the Cognitive Function and Ageing Studies) provided prevalence estimates of dependency in four states: high (24-hour care); medium (daily care); low (less than daily); independent. Years in each dependency state were calculated by Sullivan’s method. To project future demand, the proportions in each dependency state (by age group and sex) were applied to the 2014 England population projections. Findings: Between 1991 and 2011 there were significant increases in years lived from age 65 with low (men:1·7 years, 95%CI 1·0-2·4; women:2·4 years, 95%CI 1·8-3·1) and high dependency (men:0·9 years, 95%CI 0·2-1·7; women:1·3 years, 95%CI 0·5-2·1). The majority of men’s extra years of life were independent (36%) or with low dependency (36%) whilst for women the majority were spent with low dependency (58%), only 5% being independent. There were substantial reductions in the proportions with medium and high dependency who lived in care homes, although, if these dependency and care home proportions remain constant in the future, further population ageing will require an extra 71,000 care home places by 2025. Interpretation: On average older men now spend 2.4 years and women 3.0 years with substantial care needs (medium or high dependency), and most will live in the community. These findings have considerable implications for older people’s families who provide the majority of unpaid care, but the findings also supply valuable new information for governments and care providers planning the resources and funding required for the care of their future ageing populations

The SEFI Maths Working Group: current offerings and future tasks

In this discussion paper we firstly summarise the current offering of the SEFI Mathematics Working Group with regard to orientation for those who are interested in the mathematical education of engineers. Based on this summary we identify directions for further work. Finally, we present some ideas of how progress might be made in these directions

Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.

BRCA1 accumulation at DNA damage sites is an important step for its function in the DNA damage response and in DNA repair. BRCA1-BRCT domains bind to proteins containing the phosphorylated serine-proline-x-phenylalanine (pSPxF) motif including Abraxas, Bach1/FancJ, and CtIP. In this study, we demonstrate that ionizing radiation (IR)-induces ATM-dependent phosphorylation of serine 404 (S404) next to the pSPxF motif. Crystal structures of BRCT/Abraxas show that phosphorylation of S404 is important for extensive interactions through the N-terminal sequence outside the pSPxF motif and leads to formation of a stable dimer. Mutation of S404 leads to deficiency in BRCA1 accumulation at DNA damage sites and cellular sensitivity to IR. In addition, two germline mutations of BRCA1 are found to disrupt the dimer interface and dimer formation. Thus, we demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR.We thank beamline scientists at Diamond Light Source for help during data collection of crystal and SAXS. The crystallization experiments were performed in the Crystallographic X-ray facility at the Department of Biochemistry, University of Cambridge. We are grateful to the Facility Manager, Dr. Dimitri Chirgadze, for his assistance in using these facilities and advice during crystal structure determination. We also thank Dr. Yanfen Hu (University of Texas Health Science Center at San Antonia) for the pFlag-BRCA1 plasmid and Dr. Angela Pacitto (University of Cambridge) for reading the manuscript. We thank Dr. Adriana Paulucci-Holthanuzen (Department of Genetics-MD Anderson Microscopy Core Facility) for assistance with images and analysis. Q.W., T.O. and T.L.B. are funded by the Wellcome Trust (Grant 093167/Z/10/Z). A.P. is an awardee of the Schissler Foundation Fellowship, the Center for Cancer Epigenetics Scholarship and the Andrew Sowell-Wade Huggins Scholarship. This work is supported by the National Institutes of Health grant (CA155025 to B.W) with funds from the University of Texas MD Anderson Cancer Center (IRG, Center for Cancer Epigenetics, Center for Genetics and Genomics Pilot Award). S.M. is funded by the Medical Research Council (grant 98101 to C.V.R.) and C.V.R. is a Royal Society Research Professor. T.K.F and B.X. are supported by National Institutes of Health grant (R01CA138804 to B.X).This is the final version of the article. It first appeared from Cell Press via http://dx.doi.org/10.1016/j.molcel.2015.12.01

"Institutional Effort": A Reality-Based Model for Assessment of Community College Productivity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67334/2/10.1177_009155218701500204.pd

Structure of Native Lens Connexin 46/50 Intercellular Channels by Cryo-EM

Gap junctions establish direct pathways for cell-to-cell communication through the assembly of twelve connexin subunits that form intercellular channels connecting neighbouring cells. Co-assembly of different connexin isoforms produces channels with unique properties and enables communication across cell types. Here we used single-particle cryo-electron microscopy to investigate the structural basis of connexin co-assembly in native lens gap junction channels composed of connexin 46 and connexin 50 (Cx46/50). We provide the first comparative analysis to connexin 26 (Cx26), which—together with computational studies—elucidates key energetic features governing gap junction permselectivity. Cx46/50 adopts an open-state conformation that is distinct from the Cx26 crystal structure, yet it appears to be stabilized by a conserved set of hydrophobic anchoring residues. ‘Hot spots’ of genetic mutations linked to hereditary cataract formation map to the core structural–functional elements identified in Cx46/50, suggesting explanations for many of the disease-causing effects

The Developmental Origins of a Disposition Toward Empathy: Genetic and Environmental Contributions

The authors investigated the development of a disposition toward empathy and its genetic and environmental origins. Young twins' (N ϭ 409 pairs) cognitive (hypothesis testing) and affective (empathic concern) empathy and prosocial behavior in response to simulated pain by mothers and examiners were observed at multiple time points. Children's mean level of empathy and prosociality increased from 14 to 36 months. Positive concurrent and longitudinal correlations indicated that empathy was a relatively stable disposition, generalizing across ages, across its affective and cognitive components, and across mother and examiner. Multivariate genetic analyses showed that genetic effects increased, and that shared environmental effects decreased, with age. Genetic effects contributed to both change and continuity in children's empathy, whereas shared environmental effects contributed to stability and nonshared environmental effects contributed to change. Empathy was associated with prosocial behavior, and this relationship was mainly due to environmental effects