The relationship between basal and acute HPA axis activity and aggressive behavior in adults

The hypothalamic–pituitary–adrenal (HPA) axis seems to play a major role in the development, elicitation, and enhancement of aggressive behavior in animals. Increasing evidence suggests that this is also true for humans. However, most human research on the role of the HPA axis in aggression has been focusing on highly aggressive children and adolescent clinical samples. Here, we report on a study of the role of basal and acute HPA axis activity in a sample of 20 healthy male and female adults. We used the Taylor Aggression Paradigm to induce and measure aggression. We assessed the cortisol awakening response as a trait measure of basal HPA axis activity. Salivary free cortisol measures for the cortisol awakening response were obtained on three consecutive weekdays immediately following awakening and 30, 45, and 60 min after. Half of the subjects were provoked with the Taylor Aggression Paradigm to behave aggressively; the other half was not provoked. Acute HPA axis activity was measured four times, once before and three times after the induction of aggression. Basal cortisol levels were significantly and negatively related to aggressive behavior in the provoked group and explained 67% of the behavioral variance. Cortisol levels following the induction of aggression were significantly higher in the provoked group when baseline levels were taken into account. The data implicate that the HPA axis is not only relevant to the expression of aggressive behavior in clinical groups, but also to a large extent in healthy ones

Influence of aggression on information processing in the emotional Stroop task - an event-related potential study

Aggression is a common behavior which has frequently been explained as involving changes in higher level information processing patterns. Although researchers have started only recently to investigate information processing in healthy individuals while engaged in aggressive behavior, the impact of aggression on information processing beyond an aggressive encounter remains unclear. In an ERP study, we investigated the processing of facial expressions (happy, angry, fearful, and neutral) in an emotional Stroop task after experimentally provoking aggressive behavior in healthy participants. Compared to a non-provoked group, these individuals showed increased early (P2) and late (P3) positive amplitudes for all facial expressions. For the P2 amplitude, the effect of provocation was greatest for threat-related expressions. Beyond this, a bias for emotional expressions, i.e., slower reaction times to all emotional expressions, was found in provoked participants with a high level of trait anger. These results indicate significant effects of aggression on information processing, which last beyond the aggressive encounter even in healthy participants

Influence of acute stress on response inhibition in healthy men: An ERP study

The current study investigated the influence of acute stress and the resulting cortisol increase on response inhibition and its underlying cortical processes, using EEG. Before and after an acute stressor or a control condition, 39 healthy men performed a go/no-go task while ERPs (N2, P3), reaction times, errors, and salivary cortisol were measured. Acute stress impaired neither accuracy nor reaction times, but differentially affected the neural correlates of response inhibition; namely, stress led to enhanced amplitudes of the N2 difference waves (N2d, no-go minus go), indicating enhanced response inhibition and conflict monitoring. Moreover, participants responding to the stressor with an acute substantial rise in cortisol (high cortisol responders) showed reduced amplitudes of the P3 of the difference waves (P3d, no-go minus go) after the stressor, indicating an impaired evaluation and finalization of the inhibitory process. Our findings indicate that stress leads to a reallocation of cognitive resources to the neural subprocesses of inhibitory control, strengthening premotor response inhibition and the detection of response conflict, while concurrently diminishing the subsequent finalization process within the stream of processing