A first update on mapping the human genetic architecture of COVID-19

peer reviewe

(Non)Persistent Effects of Fertility on Female Labour Supply

The negative association between fertility and female labour supply is complicated by the endogeneity of fertility. We address this problem by using an exogenous variation in family size caused by infertility shocks, related to the fact that nature prevents some women from achieving their desired fertility levels. Despite a widely-documented reduction of female labour supply around childbirth, using the SHIW we find that this effect dissipates over time, with some signs of penalties relating to job quality and careers. Results are confirmed by exploiting the Birth Survey, with insights of a different impact according to the age of the child

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p