Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function

Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown. To address this, female and male Sprague-Dawley rats were randomly assigned to voluntary wheel-running or control groups; they were anesthetized after 6–8 wk of training, and myocytes were isolated. Exercise training significantly increased APD of apex and base myocytes at 1 Hz and decreased APD at 10 Hz. Ca2+ transient durations reflected the changes in APD, while Ca2+ transient amplitudes were unaffected by wheel running. The nonselective β-AR agonist isoproterenol shortened the myocyte APD, an effect reduced by wheel running. The isoproterenol-induced shortening of APD was largely reversed by the selective β1-AR blocker atenolol, but not the β2-AR blocker ICI 118,551, providing evidence that wheel running reduced the sensitivity of the β1-AR. At 10 Hz, the KATP channel inhibitor glibenclamide prolonged the myocyte APD more in exercise-trained than control rats, implicating a role for this channel in the exercise-induced APD shortening at 10 Hz. A novel finding of this work was the dual importance of altered β1-AR responsiveness and KATP channel function in the training-induced regulation of APD. Of physiological importance to the beating heart, the reduced response to adrenergic agonists would enhance cardiac contractility at resting rates, where sympathetic drive is low, by prolonging APD and Ca2+ influx; during exercise, an increase in KATP channel activity would shorten APD and, thus, protect the heart against Ca2+ overload or inadequate filling

Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function

Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown. To address this, female and male Sprague-Dawley rats were randomly assigned to voluntary wheel-running or control groups; they were anesthetized after 6–8 wk of training, and myocytes were isolated. Exercise training significantly increased APD of apex and base myocytes at 1 Hz and decreased APD at 10 Hz. Ca2+ transient durations reflected the changes in APD, while Ca2+ transient amplitudes were unaffected by wheel running. The nonselective β-AR agonist isoproterenol shortened the myocyte APD, an effect reduced by wheel running. The isoproterenol-induced shortening of APD was largely reversed by the selective β1-AR blocker atenolol, but not the β2-AR blocker ICI 118,551, providing evidence that wheel running reduced the sensitivity of the β1-AR. At 10 Hz, the KATP channel inhibitor glibenclamide prolonged the myocyte APD more in exercise-trained than control rats, implicating a role for this channel in the exercise-induced APD shortening at 10 Hz. A novel finding of this work was the dual importance of altered β1-AR responsiveness and KATP channel function in the training-induced regulation of APD. Of physiological importance to the beating heart, the reduced response to adrenergic agonists would enhance cardiac contractility at resting rates, where sympathetic drive is low, by prolonging APD and Ca2+ influx; during exercise, an increase in KATP channel activity would shorten APD and, thus, protect the heart against Ca2+ overload or inadequate filling

Inter-satellite Quantum Key Distribution at Terahertz Frequencies

Terahertz (THz) communication is a topic of much research in the context of high-capacity next-generation wireless networks. Quantum communication is also a topic of intensive research, most recently in the context of space-based deployments. In this work we explore the use of THz frequencies as a means to achieve quantum communication within a constellation of micro-satellites in Low-Earth-Orbit (LEO). Quantum communication between the micro-satellite constellation and high-altitude terrestrial stations is also investigated. Our work demonstrates that THz quantum entanglement distribution and THz quantum key distribution are viable deployment options in the micro-satellite context. We discuss how such deployment opens up the possibility for simpler integration of global quantum and wireless networks. The possibility of using THz frequencies for quantum-radar applications in the context of LEO deployments is briefly discussed.Comment: 7 pages, 6 figure

Detecting Orbital Angular Momentum of Light in Satellite-to-Ground Quantum Communications

Satellite-based quantum communications enable a bright future for global-scale information security. However, the spin orbital momentum of light, currently used in many mainstream quantum communication systems, only allows for quantum encoding in a two-dimensional Hilbert space. The orbital angular momentum (OAM) of light, on the other hand, enables quantum encoding in higher-dimensional Hilbert spaces, opening up new opportunities for high-capacity quantum communications. Due to its turbulence-induced decoherence effects, however, the atmospheric channel may limit the practical usage of OAM. In order to determine whether OAM is useful for satellite-based quantum communications, we numerically investigate the detection likelihoods for OAM states that traverse satellite-to-ground channels. We show that the use of OAM through such channels is in fact feasible. We use our new results to then investigate design specifications that could improve OAM detection - particularly the use of advanced adaptive optics techniques. Finally, we discuss how our work provides new insights into future implementations of space-based OAM systems within the context of quantum communications.Comment: 7 pages, 7 figure

Combinatorial cobordism maps in hat Heegaard Floer theory

In a previous paper, Sarkar and the third author gave a combinatorial description of the hat version of Heegaard Floer homology for three-manifolds. Given a cobordism between two connected three-manifolds, there is an induced map between their Heegaard Floer homologies. Assume that the first homology group of each boundary component surjects onto the first homology group of the cobordism (modulo torsion). Under this assumption, we present a procedure for finding the rank of the induced Heegaard Floer map combinatorially, in the hat version.Comment: 34 pages, 31 figures; discussion now limited to cobordisms satisfying a homological assumption; Section 4 completely rewritten; various other revisions; this version to appear in Duke Math.

Replica Monte Carlo Simulation (Revisited)

In 1986, Swendsen and Wang proposed a replica Monte Carlo algorithm for spin glasses [Phys. Rev. Lett. 57 (1986) 2607]. Two important ingredients are present, (1) the use of a collection of systems (replicas) at different of temperatures, but with the same random couplings, (2) defining and flipping clusters. Exchange of information between the systems is facilitated by fixing the tau spin (tau=sigma^1\sigma^2) and flipping the two neighboring systems simultaneously. In this talk, we discuss this algorithm and its relationship to replica exchange (also known as parallel tempering) and Houdayer's cluster algorithm for spin glasses. We review some of the early results obtained using this algorithm. We also present new results for the correlation times of replica Monte Carlo dynamics in two and three dimensions and compare them with replica exchange.Comment: For "Statistical Physics of Disordered Systems and Its Applications", 12-15 July 2004, Shonan Village Center, Hayama, Japan, 7 page

Multi-Stream Inflation in a Landscape

There are hidden observables for inflation, such as features localized in position space, which do not manifest themselves when only one inflation trajectory is considered. To address this issue, we investigate inflation dynamics in a landscape mimicked by a random potential. We calculate the probability for bifurcation of the inflation trajectory in multi-stream inflation. Depending on the shape of the random bumps and the distance between bumps in the potential, there is a phase transition: on one side of the critical curve in parameter space isocurvature fluctuation are exponentially amplified and bifurcation becomes very probable. On the other side bifurcation is dominated by a random walk where bifurcations are less likely to happen.Comment: Reference added to match published version in JCA