Criminal Lives 1780-1925: Punishing Old Bailey Convicts

Between 1700 and 1900 the British government stopped punishing the bodies of London’s convicts and increasingly sought to exile them and/or reform their minds. From hanging, branding and whipping the response to crime shifted to transportation and imprisonment. By the nineteenth century, judges chose between two contrasting forms of punishments: exile and forced labour in Australia, or incarceration in strictly controlled ‘reformatory’ prisons at home. This exhibition, based on material from London Metropolitan Archives and the AHRC funded Digital Panopticon research project, traces the impact of punishments on individual lives. It follows the men, women and children convicted in London from their crimes and trials through to their experiences of punishment and their subsequent lives.This exhibition was contracted by and displayed at the London Metropolitan Archives. It received additional funding from the AHRC Digital Panopticon network as well as specific impact and engagement funding from The University of Sheffield and The University of Sussex

Optical dispersion relations for diamondlike carbon films

Ellipsometric measurements on plasma deposited diamondlike amorphous carbon (a-C:H) films were taken in the visible, (E = 1.75 to 3.5 eV). The films were deposited on Si and their properties were varied using high temperature (up to 750 C) anneals. The real (n) and imaginary (k) parts of the complex index of refraction, N, were obtained simultaneously. Following the theory of Forouhi and Bloomer, a least squares fit was used to find the dispersion relations n(E) and k(E). Reasonably good fits were obtained, showing that the theory can be used for a-C:H films. Moreover, the value of the energy gap, Eg, obtained in this way was compared the the Eg value using conventional Tauc plots and reasonably good agreement was obtained

Tall Fescue (\u3cem\u3eFestuca arundinacea\u3c/em\u3e) Stockpiling Response to N Fertilizer in Southern Virginia as Affected by Biological Soil Quality

Cattlemen in the eastern USA profitably utilize endophyte-infected tall fescue (Festuca arundinacea) for fall-stockpiled winter grazing. Ergot alkaloid concentration in fescue tends to decline in winter. This improves the quality of fescue for grazing when the supply of other forage becomes limited on most farms. Tall fescue dry matter yields generally respond favorably to nitrogen (N) inputs, but response can be limited with summer application due to accumulation of biologically available N in soil. Research is needed to characterize a diversity of pastures for response to N fertilizer during fall stockpiling. Biological soil quality can be estimated with a simple measure of soil respiration following rewetting of dried soil (Franzluebbers et al., 2000). The flush of CO2 following rewetting of dried soil has been related to the quantity of N mineralized during longer term incubations (Franzluebbers and Haney, 2006) and to N uptake in field studies of forage growth (Haney et al., 2001). Soil was collected from a set of pastures in southern Virginia to characterize biological soil quality and determine dry matter yield response to fertilizer N inputs

Impact of Long-Term Endurance Training vs. Guideline-Based Physical Activity on Brain Structure in Healthy Aging

Brain structure is a fundamental determinant of brain function, both of which decline with age in the adult. Whereas short-term exercise improves brain size in older adults, the impact of endurance training on brain structure when initiated early and sustained throughout life, remains unknown. We tested the hypothesis that long-term competitive aerobic training enhances cortical and subcortical mass compared to middle to older-aged healthy adults who adhere to the minimum physical activity guidelines. Observations were made in 16 masters athletes (MA; 53 ± 6 years, VO2max = 55 ± 10 ml/kg/min, training \u3e 15 years), and 16 active, healthy, and cognitively intact subjects (HA; 58 ± 9 years, VO2max = 38 ± 7 ml/kg/min). T1-weighted structural acquisition at 3T enabled quantification of cortical thickness and subcortical gray and white matter volumes. Cardiorespiratory fitness correlated strongly with whole-brain cortical thickness. Subcortical volumetric mass at the lateral ventricles, R hippocampus, R amygdala, and anterior cingulate cortex, correlated with age but not fitness. In a region-of-interest (ROI) group-based analysis, MA expressed greater cortical thickness in the medial prefrontal cortex, pre and postcentral gyri, and insula. There was no effect of group on the rate of age-related cortical or subcortical decline. The current data suggest that lifelong endurance training that produces high levels of cardiorespiratory fitness, builds cortical reserve early in life, and sustains this benefit over the 40–70 year age span. This reserve likely has important implications for neurological health later in life

Unifying The Body Of Knowledge: Why Global Business Requires A Single Model For Information Security

Every sector in the global economy, from energy, through transportation, finance and banking, telecommunications, public health, emergency services, water, chemical, defense, right down to the industrial, and agriculture sectors, is totally dependent on the reliable functioning of its IT assets. Thus anything that threatens these effectively poses a threat to our way of life. And accordingly, almost any effort expended to protect them is both justifiable and necessary. So the obvious question is… “What is the current state of affairs”?

Impact of long-term endurance training vs. guideline-based physical activity on brain structure in healthy aging

© 2016 Wood, Nikolov and Shoemaker. Brain structure is a fundamental determinant of brain function, both of which decline with age in the adult. Whereas short-term exercise improves brain size in older adults, the impact of endurance training on brain structure when initiated early and sustained throughout life, remains unknown. We tested the hypothesis that long-term competitive aerobic training enhances cortical and subcortical mass compared to middle to older-aged healthy adults who adhere to the minimum physical activity guidelines. Observations were made in 16 masters athletes (MA; 53 ± 6 years, VO2max = 55 ± 10 ml/kg/min, training \u3e 15 years), and 16 active, healthy, and cognitively intact subjects (HA; 58 ± 9 years, VO2max = 38 ± 7 ml/kg/min). T1-weighted structural acquisition at 3T enabled quantification of cortical thickness and subcortical gray and white matter volumes. Cardiorespiratory fitness correlated strongly with whole-brain cortical thickness. Subcortical volumetric mass at the lateral ventricles, R hippocampus, R amygdala, and anterior cingulate cortex, correlated with age but not fitness. In a region-of-interest (ROI) group-based analysis, MA expressed greater cortical thickness in the medial prefrontal cortex, pre and postcentral gyri, and insula. There was no effect of group on the rate of age-related cortical or subcortical decline. The current data suggest that lifelong endurance training that produces high levels of cardiorespiratory fitness, builds cortical reserve early in life, and sustains this benefit over the 40-70 year age span. This reserve likely has important implications for neurological health later in life

Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

<p>Abstract</p> <p>Background</p> <p>Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant role in modulation of drug-induced toxicity in the non-small cell lung cancer cell line model, NCI-H522.</p> <p>Methods</p> <p>The transcriptional response of NCI-H522 to adaphostin prominently involved oxidative stress genes, particularly HMOX1. Reactive oxygen species (ROS) involvement was additionally established by generation of ROS prior to modulation of adaphostin-toxicity with antioxidants. To identify up-stream regulatory elements of HMOX1, immunofluorescence was used to evaluate nuclear translocation of the transcription factor, NF-E2-related factor 2 (Nrf2), in the presence of adaphostin. The PI3-kinase inhibitor, wortmannin, was employed as a pharmacological inhibitor of this process.</p> <p>Results</p> <p>Generation of ROS provided a substantial foundation for the sensitivity of NCI-H522 to adaphostin. However, in contrast to leukemia cell lines, transcriptional response to oxidative stress was associated with induction of HMOX1, which was dependent on nuclear translocation of the transcription factor, Nrf2. Pretreatment of cells with wortmannin inhibited translocation of Nrf2 and induction of HMOX1. Wortmannin pretreatment was also able to diminish adaphostin induction of HMOX1, and as a consequence, enhance the toxicity of adaphostin to NCI-H522.</p> <p>Conclusions</p> <p>Adaphostin-induced oxidative stress in NCI-H522 was mediated through nuclear translocation of Nrf2 leading to upregulation of HMOX1. Inhibition of Nrf2 translocation by wortmannin inhibited this cytoprotective response, and enhanced the toxicity of adaphostin, suggesting that inhibitors of the PI3K pathway, such as wortmannin, might augment the antiproliferative effects of adaphostin in solid tumors that depend on the Nrf2/ARE pathway for protection against oxidative stress.</p