Method for the preparation of new tryptanthrin o-acyloximes

Earlier [1, 2], a number of new potential inhibitors of the JNK kinase isoform family (JNK1, JNK2, JNK3) were identified, which are involved in the pathogenesis of many cardiovascular, oncological and psychosomatic diseases. One of the potential inhibitors is tryptanthrin-6-oxime (Trp-Ox), which exhibit good pan-selectivity for JNK. However, most of the compounds had low solubility in water and organic solvents and high toxicity. This work presents the synthesis of new tryptanthrin O-acyloximes with the aim of increasing their activity and / or the selectivity of the obtained analogs with respect to JNK isoforms, their hydrophilic properties and expanding the library of nitrogen-containing heterocyclic compounds, which will also be of interest to researchers studying other type biological activity

Экономика замкнутого цикла

В настоящее время человечество оказывает существенное влияние на природу и экологию. Также в современном мире усилилась проблема сохранения и использования способности окружающей среды создавать постоянный поток услуг и ресурсов, вместе с этим значительно возрастает количество отходов, производимых человечеством. На сегодняшний день появляется все больше предприятий в мире, которые с большим внимание относятся к их экологическому следу, которые стремятся к использованию концепции экономики замкнутого цикла

Прогнозирование гидравлического разрыва пласта низкопроницаемых коллекторов на основе математического моделирования на месторождении Х

Объектом исследования является месторождение нефти с низкой проницаемостью, на котором был проведен гидроразрыв пласта с целью увеличения добычи нефти. Цель работы – разработать имитационную модель гидроразрыва с использованием вариационного подхода к гидроразрыву в качестве механической модели, что позволяет использовать единую расчетную область для представления как трещины, так и коллектора, и устраняет необходимость явной идентификации трещины. и направления распространения. В процессе исследования была рассмотрена группа сложных математических моделей деформации.The object of the study is an oil field with low permeability, where hydraulic fracturing was carried out in order to increase oil production. The aim of the work is to develop a simulation model of hydraulic fracturing using a variational approach to hydraulic fracturing as a mechanical model, which allows using a single computational domain to represent both the fracture and the reservoir, and eliminates the need for explicit fracture identification. and directions of distribution. In the course of the study, a group of complex mathematical models of deformation and fluid flow was considered

Внедрение газокомпрессорной станции в систему утилизации попутного нефтяного газа

В процессе работы был рассмотрен максимально эффективный метод утилизации попутного нефтяного газа для данного месторождения, который позволяет утилизировать 95% попутного нефтяного газа.In the course of the work, the most efficient method of utilization of associated petroleum gas for this field was considered, which allows utilizing 95% of associated petroleum gas

Liver Is Able to Activate Naïve CD8+ T Cells with Dysfunctional Anti-Viral Activity in the Murine System

The liver possesses distinct tolerogenic properties because of continuous exposure to bacterial constituents and nonpathogenic food antigen. The central immune mediators required for the generation of effective immune responses in the liver environment have not been fully elucidated. In this report, we demonstrate that the liver can indeed support effector CD8+ T cells during adenovirus infection when the T cells are primed in secondary lymphoid tissues. In contrast, when viral antigen is delivered predominantly to the liver via intravenous (IV) adenovirus infection, intrahepatic CD8+ T cells are significantly impaired in their ability to produce inflammatory cytokines and lyse target cells. Additionally, intrahepatic CD8+ T cells generated during IV adenovirus infection express elevated levels of PD-1. Notably, lower doses of adenovirus infection do not rescue the impaired effector function of intrahepatic CD8+ T cell responses. Instead, intrahepatic antigen recognition limits the generation of potent anti-viral responses at both priming and effector stages of the CD8+ T cell response and accounts for the dysfunctional CD8+ T cell response observed during IV adenovirus infection. These results also implicate that manipulation of antigen delivery will facilitate the design of improved vaccination strategies to persistent viral infection

The IPBES Conceptual Framework - connecting nature and people

The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework. This conceptual and analytical tool, presented here in detail, will underpin all IPBES functions and provide structure and comparability to the syntheses that IPBES will produce at different spatial scales, on different themes, and in different regions. Salient innovative aspects of the IPBES Conceptual Framework are its transparent and participatory construction process and its explicit consideration of diverse scientific disciplines, stakeholders, and knowledge systems, including indigenous and local knowledge. Because the focus on co-construction of integrative knowledge is shared by an increasing number of initiatives worldwide, this framework should be useful beyond IPBES, for the wider research and knowledge-policy communities working on the links between nature and people, such as natural, social and engineering scientists, policy-makers at different levels, and decision-makers in different sectors of society

Phylogenomics and the evolution of hemipteroid insects.

Hemipteroid insects (Paraneoptera), with over 10% of all known insect diversity, are a major component of terrestrial and aquatic ecosystems. Previous phylogenetic analyses have not consistently resolved the relationships among major hemipteroid lineages. We provide maximum likelihood-based phylogenomic analyses of a taxonomically comprehensive dataset comprising sequences of 2,395 single-copy, protein-coding genes for 193 samples of hemipteroid insects and outgroups. These analyses yield a well-supported phylogeny for hemipteroid insects. Monophyly of each of the three hemipteroid orders (Psocodea, Thysanoptera, and Hemiptera) is strongly supported, as are most relationships among suborders and families. Thysanoptera (thrips) is strongly supported as sister to Hemiptera. However, as in a recent large-scale analysis sampling all insect orders, trees from our data matrices support Psocodea (bark lice and parasitic lice) as the sister group to the holometabolous insects (those with complete metamorphosis). In contrast, four-cluster likelihood mapping of these data does not support this result. A molecular dating analysis using 23 fossil calibration points suggests hemipteroid insects began diversifying before the Carboniferous, over 365 million years ago. We also explore implications for understanding the timing of diversification, the evolution of morphological traits, and the evolution of mitochondrial genome organization. These results provide a phylogenetic framework for future studies of the group