Related lending and banking development

Does related lending have positive or negative effects on the development of banking systems? This paper analyzes a unique cross-country data set covering 74 countries from 1990 to 2007, and finds that related lending, on average, does not have any effect on the growth of credit. The authors do find, however, that there are conditional relationships: related lending tends to retard the growth of banking systems when rule of law is weak, while it tends to promote the growth of banking systems when rule of law is strong. They also find that related lending appears to be associated with looting when banks are owned by non-financial firms, but that it does not when non-financial firms are owned by banks. The results indicate that whether related lending is positive or pernicious depends critically on the institutional context in which it takes place; there is no single"best policy"regarding related lending. These findings are robust to alternative specifications, including instrumental variable regressions.Banks&Banking Reform,Debt Markets,Bankruptcy and Resolution of Financial Distress,Labor Policies,Economic Theory&Research

Student Impression Management in the Classroom

With the growing shift from lecture-style teaching methods to interactive and experiential group exercises, instructors need to know more about their students, such as their desired impressions, to adequately engage and support students’ social interactions. This study addresses this need by providing an overall understanding of the types of images that are important for students to project when interacting with others in a classroom. After a concise review of impression management literature and grounding our reasoning in cybernetic theory (Bozeman & Kacmar, 1997) this study offers an insight of the positive impressions students desire to project in front of their peers and professors and the negative impressions students aim to avoid. With a two-part survey based on 269 responses, we measured students’ ranking of specific images and the effort level they exerted towards achieving or avoiding them. We offer suggestions of how these findings can be integrated into teaching for improved student learning and experiences

What can the L3 γγll\gamma\gamma ll events be?

We consider the 4 $\gamma\gamma ll$ ($l=\mu,\ e$) events reported by the L3 collaboration, and go through the logical possibilities which could explain the events. If they are not coincidental bremsstrahlung events, we find that the physics which they could point to is extremely limited. One possibility would be to have a new 60 GeV scalar (or pseudoscalar) particle $X^0$ with an off-diagonal coupling to a $Z$ and $Z'$ which is non-perturbative ($\alpha > 1$), where the $Z'$ couplings to $\nu\bar\nu$ are suppressed. One could also construct a model involving $X^0$, and a second scalar $X'^0$ with a large $X'll$ coupling. We do not promote either of these models, but hope they would prove to be useful guidelines, should the L3 events turn out to be new physics.Comment: 7 pp (3 fig avail. on request), LATEX, TRI-PP-92-12

Surgery-Guided Removal of Ovarian Cancer Using Up-Converting Nanoparticles

Ovarian cancer survival and the recurrence rate are drastically affected by the amount of tumor that can be surgically removed prior to chemotherapy. Surgeons are currently limited to visual inspection, making smaller tumors difficult to be removed surgically. Enhancing the surgeon’s ability to selectively remove cancerous tissue would have a positive effect on a patient’s prognosis. One approach to aid in surgical tumor removal involves using targeted fluorescent probes to selectively label cancerous tissue. To date, there has been a trade-off in balancing two requirements for the surgeon: the ability to see maximal tumors and the ability to identify these tumors by eye while performing the surgery. The ability to see maximal tumors has been prioritized and this has led to the use of fluorophores activated by near-infrared (NIR) light as NIR penetrates most deeply in this surgical setting, but the light emitted by traditional NIR fluorophores is invisible to the naked eye. This has necessitated the use of specialty detectors and monitors that the surgeon must consult while performing the surgery. In this study, we develop nanoparticles that selectively label ovarian tumors and are activated by NIR light but emit visible light. This potentially allows for maximal tumor observation and real-time detection by eye during surgery. We designed two generations of up-converting nanoparticles that emit green light when illuminated with NIR light. These particles specifically label ovarian tumors most likely via tumor-associated macrophages, which are prominent in the tumor microenvironment. Our results demonstrate that this approach is a viable means of visualizing tumors during surgery without the need for complicated, expensive, and bulky detection equipment. Continued improvement and experimentation could expand our approach into a much needed surgical technique to aid ovarian tumor removal

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.

Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC). RB function is exquisitely controlled by a series of proteins, including the CyclinD-CDK4/6 complex. In this study, we interrogated the capacity of a CDK4/6 inhibitor, palbociclib, to activate RB function. Experimental Design and Results: We employed multiple isogenic RB-proficient and -deficient NSCLC lines to interrogate the cytostatic and cytotoxic capacity of CDK 4/6 inhibition in vitro and in vivo We demonstrate that while short-term exposure to palbociclib induces cellular senescence, prolonged exposure results in inhibition of tumor growth. Mechanistically, CDK 4/6 inhibition induces a proapoptotic transcriptional program through suppression of IAPs FOXM1 and Survivin, while simultaneously augmenting expression of SMAC and caspase-3 in an RB-dependent manner. Conclusions: This study uncovers a novel function of RB activation to induce cellular apoptosis through therapeutic administration of a palbociclib and provides a rationale for the clinical evaluation of CDK 4/6 inhibitors in the treatment of patients with NSCLC

Supersymmetric Electroweak Parity Nonconservation in Top Quark Pair Production at the Fermilab Tevatron

We evaluate the supersymmetric (SUSY) electroweak corrections to the effect of parity nonconservation in $q {\bar q} \to t {\bar t}$ production at the Fermilab Tevatron predicted by the Minimal Supersymmetric Model (MSSM). We find that the parity nonconserving asymmetry from the SUSY electroweak and SUSY Yukawa loop corrections predicted by the minimal supergravity (mSUGRA) model and the MSSM models with scenarios motivated by current data is about one percent. It will be challenging to observe such a small asymmetry at the Tevatron with 10 fb^{-1} of luminosity. It could however be observable if both the top- and bottom-squarks are light and $\tan \beta$ is smaller than 1, though theses parameters are not favored by mSUGRA.Comment: revised version, some new numerical results adde

Higgs-boson production associated with a bottom quark at hadron colliders with SUSY-QCD corrections

The Higgs boson production p p (p\bar p) -> b h +X via b g -> b h at the LHC, which may be an important channel for testing the bottom quark Yukawa coupling, is subject to large supersymmetric quantum corrections. In this work the one-loop SUSY-QCD corrections to this process are evaluated and are found to be quite sizable in some parameter space. We also study the behavior of the corrections in the limit of heavy SUSY masses and find the remnant effects of SUSY-QCD. These remnant effects, which are left over in the Higgs sector by the heavy sparticles, are found to be so sizable (for a light CP-odd Higgs and large \tan\beta) that they might be observable in the future LHC experiment. The exploration of such remnant effects is important for probing SUSY, especially in case that the sparticles are too heavy (above TeV) to be directly discovered at the LHC.Comment: Results for the Tevatron adde

Taking Blockchain Seriously

In the present techno-political moment it is clear that ignoring or dismissing the hype surrounding blockchain is unwise, and certainly for regulatory authorities and governments who must keep a grip on the technology and those promoting it, in order to ensure democratic accountability and regulatory legitimacy within the blockchain ecosystem and beyond. Blockchain is telling (and showing) us something very important about the evolution of capital and neoliberal economic reason, and the likely impact in the near future on forms and patterns of work, social organization, and, crucially, on communities and individuals who lack influence over the technologies and data that increasingly shape and control their lives. In this short essay I introduce some of the problems in the regulation of blockchain and offer counter-narratives aimed at cutting through the hype fuelling the ascendency of this most contemporary of technologies

Moderate Supersymmetric CP Violation

It is well known that supersymmetry (SUSY) gives neutron and electron electric dipole moments ($d_n$ and $d_e$) which are too large by about $10^{3}$. If we assume a SUSY model cannot contain fine-tunings or large mass scales, then one must require that the SUSY breaking mechanism give real soft breaking parameters, in which case the minimal SUSY model has no $CP$ violation other than from the CKM matrix (besides possible strong $CP$ violating effects). We show that in non-minimal SUSY models, a moderate amount of $CP$ violation can be induced through one loop corrections to the scalar potential, giving an effective phase of order $10^{-3}$, and thus implying $d_n$ and $d_e$ can be near their current experimental bounds $naturally$. This moderate amount of SUSY $CP$ violation could also prove important for models of electroweak baryogenesis. We illustrate our results with a specific model.Comment: 19pp plain LATEX, 1 fig (by EMAIL request), TRI-PP-93-86. (Some clarifying comments about renormalizability added--version to appear in Phys. Rev. D

Supersymmetric Electroweak Corrections to Single Top Quark Production at the Fermilab Tevatron

We have calculated the $O(\alpha_{ew} M_t^2/M_W^2)$ supersymmetric electroweak corrections to single top quark production via $q\bar q' \to t\bar b$ at the Fermilab Tevatron in the minimal supersymmetric model. The supersymmetric electroweak corrections to the cross section are a few percent for $tan \beta> 1$, and can exceed 10% for $tan\beta<1$. The combined effects of SUSY electroweak corrections and the Yukawa corrections can exceed 10% for favorable parameter values, which might be observable at a high-luminosity Tevatron.Comment: 13 pages, 4 figures available at reques