Persistence is hard, then you die! or compiler and runtime support for a persistent common Lisp.

Journal ArticleIntegrating persistence into an existing programming language is a serious undertaking. Preserving the essence of t h e existing language, adequately supporting persistence, and maintaining efficiency require low-level support from the compiler and runtime systems. Pervasive, low-level changes were made to a Lisp compiler and runtime system to introduce persistence. The result is an efficient language which is worthy of the name Persistent Lisp.

The neurobiological basis of binge-eating disorder

AbstractRelatively little is known about the neuropathophysiology of binge-eating disorder (BED). Here, the evidence from neuroimaging, neurocognitive, genetics, and animal studies are reviewed to synthesize our current understanding of the pathophysiology of BED. Binge-eating disorder may be conceptualized as an impulsive/compulsive disorder, with altered reward sensitivity and food-related attentional biases. Neuroimaging studies suggest there are corticostriatal circuitry alterations in BED similar to those observed in substance abuse, including altered function of prefrontal, insular, and orbitofrontal cortices and the striatum. Human genetics and animal studies suggest that there are changes in neurotransmitter networks, including dopaminergic and opioidergic systems, associated with binge-eating behaviors. Overall, the current evidence suggests that BED may be related to maladaptation of the corticostriatal circuitry regulating motivation and impulse control similar to that found in other impulsive/compulsive disorders. Further studies are needed to understand the genetics of BED and how neurotransmitter activity and neurocircuitry function are altered in BED and how pharmacotherapies may influence these systems to reduce BED symptoms

Stability of Polyadenylated RNA in Differentiating Myogenic Cells

Three independent methods of measurement showed that cytoplasmic polyadenylated RNA from the differentiating myogenic cell line L8 consists of two main populations with regard to stability, one with a half-life of less than 4 h and the other with a half-life of 17-54 h. Similar results were obtained in the presence and absence of actinomycin D. During the fusion of mononucleated myoblasts into multinucleated fibers, there was an increase in both the steady-state pool of the more stable polyadenylated RNA and the proportion of stable polyadenylated RNA synthesized in pulse labelling. In the last few years, techniques have become available for the isolation of messenger RNA by virtue of molecular hybridization of a 3 '-terminal polyadenylate residue, poly(A), on the mRNA with a cellulose-bound residue of oligothymidylate, oligo(dT) [l]. Analysis of the kinetics of synthesis and decay of polyadenylated RNA in HeLa cells isolated in this way [2,22] showed that there existed two populations of RNA: a labile population with a half-life of 7 h, constituting 33'x of the steady-state pool of polyadenylated RNA, and a more stable population with a half-life of 22 h (generation time of HeLa cells), constituting 67 : d of the steady-state pool. The stable RNA had a smaller average molecular size than the more labile population. The aim of the present work was to undertake a similar kind of analysis with differentiating cells, myoblasts, in order to ascertain whether such two populations of mRNA exist in these cells and whether they may be implicated in the process of cellular differentiation. Although no systematic analysis has been undertaken of the stability of mRNA in differentiating cells, two lines of evidence indicate that proteins specific to differentiated cells may be coded for by long-lived mRNA. The first is a result of measurement of the accumulation of label into mRNAs in differentiated cells which produce large amounts of specific proteins such as ovalbumin In order to examine the stability of mRNA during the differentiation of muscle cells, a quantitative study was made of the kinetics of polyadenylated RNA decay in actinomycin-D-treated and untreated muscle cultures. The cells used in most of the experiments were from a myogenic cell line, L8, of rat skeletal muscle origin [15,16]. This is a homogeneous, cloned population, and when it is plated at 2 x lo5 cells/lOO-mm culture dish, it proliferates rapidly until confluent, then ceases growing. About 30 h later, the cells start to fuse and form multinucleated fibers. Fusion proceeds rapidly over the course of 2 days and is closely followed by the synthesis of muscle-specific proteins [12,13,16]. At the end of this period over 70% of the cells have fused into myotubes. The cultures subsist for several more days before showing signs of degeneration. The obvious morphological stages during the differentiation of these cultures make this system very convenient for a study of quantitative changes in metabolism of mRNA during cell differentiation

Supportive interactions, negative interactions, and depressed mood

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44025/1/10464_2004_Article_BF00938116.pd

Towards an Understanding of the Mid-Infrared Surface Brightness of Normal Galaxies

We report a mid-infrared color and surface brightness analysis of IC 10, NGC 1313, and NGC 6946, three of the nearby galaxies studied under the Infrared Space Observatory Key Project on Normal Galaxies. Images with < 9 arcsecond (170 pc) resolution of these nearly face-on, late-type galaxies were obtained using the LW2 (6.75 mu) and LW3 (15 mu) ISOCAM filters. Though their global I_nu(6.75 mu)/I_nu(15 mu) flux ratios are similar and typical of normal galaxies, they show distinct trends of this color ratio with mid-infrared surface brightness. We find that I_nu(6.75 mu)/I_nu(15 mu) ~< 1 only occurs for regions of intense heating activity where the continuum rises at 15 micron and where PAH destruction can play an important role. The shape of the color-surface brightness trend also appears to depend, to the second-order, on the hardness of the ionizing radiation. We discuss these findings in the context of a two-component model for the phases of the interstellar medium and suggest that star formation intensity is largely responsible for the mid-infrared surface brightness and colors within normal galaxies, whereas differences in dust column density are the primary drivers of variations in the mid-infrared surface brightness between the disks of normal galaxies.Comment: 19 pages, 6 figures, uses AAS LaTeX; to appear in the November Astronomical Journa

Signed zeros of Gaussian vector fields-density, correlation functions and curvature

We calculate correlation functions of the (signed) density of zeros of Gaussian distributed vector fields. We are able to express correlation functions of arbitrary order through the curvature tensor of a certain abstract Riemann-Cartan or Riemannian manifold. As an application, we discuss one- and two-point functions. The zeros of a two-dimensional Gaussian vector field model the distribution of topological defects in the high-temperature phase of two-dimensional systems with orientational degrees of freedom, such as superfluid films, thin superconductors and liquid crystals.Comment: 14 pages, 1 figure, uses iopart.cls, improved presentation, to appear in J. Phys.

Prospective associations of perceived unit cohesion with postdeployment mental health outcomes

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149506/1/da22884_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149506/2/da22884.pd

Six-month outcomes of a web-based intervention for users of amphetamine-type stimulants: Randomized controlled trial

Background: The use of amphetamine-type stimulants (ATS) places a large burden on health services.Objective: The aim was to evaluate the effectiveness of a self-guided Web-based intervention (“breakingtheice”) for ATS users over 6 months via a free-to-access site.Methods: We conducted a randomized trial comparing a waitlist control with a fully automated intervention containing 3 modules derived from cognitive behavioral therapy and motivation enhancement. The main outcome was self-reported ATS use in the past 3 months assessed at 3- and 6-month follow-ups using the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). Secondary outcomes were help-seeking intentions (general help-seeking questionnaire), actual help seeking (actual help-seeking questionnaire), psychological distress (Kessler 10), polydrug use (ASSIST), quality of life (European Health Interview Survey), days out of role, and readiness to change. Follow-up data were evaluated using an intention-to-treat (ITT) analysis with a group by time interaction.Results: We randomized 160 people (intervention: n=81; control: n=79). At 6 months, 38 of 81 (47%) intervention and 41 of 79 (52%) control participants provided data. ATS scores significantly declined for both groups, but the interaction effect was not significant. There were significant ITT time by group interactions for actual help seeking (rate ratio [RR] 2.16; d=0.45) and help-seeking intentions (RR 1.17; d=0.32), with help seeking increasing for the intervention group and declining for the control group. There were also significant interactions for days completely (RR 0.50) and partially (RR 0.74) out of role favoring the intervention group. However, 37% (30/81) of the intervention group did not complete even 1 module.Conclusions: This self-guided Web-based intervention encouraged help seeking associated with ATS use and reduced days out of role, but it did not reduce ATS use. Thus, this program provides a means of engaging with some sections of a difficult-to-reach group to encourage treatment, but a substantial minority remained disengaged.Trial Registration: Australian and New Zealand Clinical Trials Registry: ACTRN12611000947909;https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=343307 (Archived by WebCite athttp://www.webcitation.org/6Y0PGGp8q).URL http://dx.doi.org/10.2196/jmir.3778</a