47 research outputs found
Do the Terms “% ee” and “% de” Make Sense as Expressions of Stereoisomer Composition or Stereoselectivity?
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Configurational and Conformational Effects on Tin−Lithium Exchange in α-Aminoorganostannanes by Rapid-Injection NMR
No full text1-Magnesiotetrahydroisoquinolyloxazolines as Chiral Nucleophiles in Stereoselective Additions to Aldehydes: Auxiliary Optimization, Asymmetric Synthesis of (+)-Corlumine, (+)-Bicuculline, (+)-Egenine, and (+)-Corytensine, and Preliminary 13
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An Improved Synthesis of a Trifurcated Newkome-Type Monomer and Orthogonally Protected Two-Generation Dendrons
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Novel Modulator of NaV1.1 and NaV1.2 Na+ Channels in Rat Neuronal Cells
No full textA novel modulator of sodium ion currents was synthesized in 6 steps from a protected dihydroxypyrrolidine nitrone,
via
1,3-dipolar cycloaddition reaction with acrylamide. Sodium ion currents in B50 cells were evaluated in comparison to saxitoxin and tetrodotoxin and revealed an IC
50
of 15.7 μM. The new compound shows no evidence of binding to the C-lobe of the saxitoxin-binding protein saxiphilin
