6 research outputs found
Inter and intraspecific variation in fish body size constrains microhabitat use in a subtropical drainage
- Author
- A Akbaripasand
- A Signore Del
- AJH Davey
- B Hugueny
- BC Harvey
- BE Henry
- BM Wood
- C Violle
- CA Roa-Fuentes
- DA Arrington
- DA Crook
- DA Jackson
- DD Magoulick
- DI Bolnick
- ED Wikramanayake
- FA Hockley
- FD Shields
- G Woodward
- GD Grossman
- GD Grossman
- GK Meffe
- IJ Schlosser
- J Gross
- J Oksanen
- J Regis
- JA Stefferud
- JF Gilliam
- K Bartoń
- K Warburton
- L Casatti
- L Casatti
- LR Manna
- Lucas De Fries
- M Arim
- M Camana
- MB Bain
- MD Ribeiro
- ME Douglas
- NL Poff
- NR Franssen
- P Legendre
- R Core Team
- R Mazzoni
- RB Dala-Corte
- RB Langerhans
- Renato B. Dala-Corte
- RH Peters
- RP Leitão
- S Nakagawa
- SE Steele
- T Bie De
- T Zhao
- TM Blackburn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Using community phylogenetics to assess phylogenetic structure in the Fitzcarrald region of Western Amazonia
- Author
- Abreu JMS
- Albert JS
- Albert JS
- Albert JS
- Albert JS
- Albert JS
- Albert JS
- Amador L
- Araujo-Lima C
- Arrington DA
- Barfknecht DF
- Barthem RB
- Belmaker J
- Betancur-R R
- Bloom DD
- Bower LM
- Caldas FLS
- Caley MJ
- Carvalho TP
- Carvalho TP
- Carvalho TP
- Cavender-Bares J
- Chiachio MC
- Craig JM
- Cramer CA
- Crampton WGR
- Dagosta FCP
- de Pinna MCC
- de Souza LS
- Dexter KG
- Emerson BC
- Espurt N
- Ewers RM
- Floeter SR
- García-Navas V
- Harrison S
- Hawkins BA
- Hernán Ortega
- Jack M. Craig
- James S. Albert
- Kembel SW
- Kembel SW
- Kennedy JD
- Kumar S
- Leprieur F
- Lessard JH
- Losos JB
- Lovejoy NR
- Lujan NK
- Lujan NK
- Lundberg JG
- López-Fernández H
- Marki PZ
- Mastrogianni A
- Melo BF
- Mendonça FP
- Mirande JM
- Muss A
- Oberdorff T
- Ortí G
- Palumbi SR
- Paradis E
- Paulo Petry
- Pearse WD
- Pearse WD
- Pearse WD
- Picq S
- Prosanta Chakrabarty
- Pugedo ML
- Qin TJ
- Rambaut A
- Reis RE
- Roa-Fuentes CA
- Roberto E. Reis
- Roxo FF
- Santorelli S
- Sargent RD
- Schaefer SA
- Stewart DJ
- Strauss SY
- Sullivan JP
- Sullivan JP
- Swenson NG
- Tagliacollo V
- Tagliacollo VA
- Thomaz AT
- Tiago P. Carvalho
- Valerie Derouen
- Vamosi SM
- Van der Sleen P
- Victor A. Tagliacollo
- Ward RD
- Webb CO
- Webb CO
- Webb CO
- Westoby M
- Willis SC
- Zheng Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2020
- Field of study
Subsistence hunting of Podocnemis lewyana and Rhinoclemmys melanosterna (Testudines) in the region of the low San Jorge River, Caribbean, Colombia
- Author
- Aguilera D�az MM.
- Alvard M.
- Cort�s-Gregorio I Pascual-Ramos E, Medina-Torres SM, Sandoval-Forero EA, Lara-Ponce E, Pi-a-Ru�z HH, Mart�nez-Ru�z R, Rojo-Mart�nez GE.
- David DJ Aguirre-Ram�rez NJ, V�lez-Mac�as FB.
- De La Ossa J Olivero-G G, Ruiz J.G.
- De La Ossa VJ De La Ossa-Lacayo A.
- De La Ossa VJ Vogt RC.
- Fuentes-Obeid S Sampedro MA, Ardila-Marulanda M.
- Gonz�lez-Z�rate A Montenegro O, Casta-o-Mora OV, Vargas-Ram�rez M.
- Guerra Roa MM Naranjo Pi-era EJ, Lim�n Aguirre F, Mariaca M�ndez R.
- Hern�ndez O Esp�n R.
- Lira-Torres I Briones-Salas M, G�mez De Anda FR, Ojeda- Ram�rez D, Pel�ez Acero A.
- Medem F.
- Peres CA.
- Redford KH Sanderson S.
- Valencia-Parra E De La Ossa VJ.
- V�zquez Garc�a V God�nez Guevara ML.
- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study
Ecomorphological relationships of fish assemblages in a trans-Andean drainage, Upper Magdalena River Basin, Colombia
- Author
- Abujanra F Agostinho AA
- Aguirre WE
- Alvarez-Leon R
- Anderson EP
- Anderson MJ
- Barletta M
- Binning SA
- Bock WJ
- Bock WJ
- Bower LM
- Breda L
- Buitrago UA
- Carvajal-Quintero JD
- Casatti L
- Cristhian C. Conde-Saldaña
- Crop W
- Cunico AM
- Dahl G
- De La Barra E
- Delariva RL
- Douglas ME
- Dufrêne M
- Edwin O. López-Delgado
- Eigenmann CJ
- Eigenmann CJ
- Fernandes R
- Fernández EM
- Ferreira KM
- Francisco A. Villa-Navarro
- Fugi R
- Gatz J
- Gatz J
- Gibran FZ
- Harold AS
- Hora SL
- Hugueny B
- Jackson DA
- Jaramillo-Villa U
- Jiménez-Segura LF
- Juan G. Albornoz-Garzón
- Keast A
- Langerhans RB
- Lannoo MJ
- Legendre P
- Lomolino MV
- Lozano-Zárate YY
- Lundberg JG
- López-Delgado E
- Maio C
- Malato G
- Maldonado-Ocampo JA
- Miles C
- Montgomery DC
- Mérigoux S
- Neves MP
- Nikolski GV
- Novakowski GC
- Nunes DM
- Oliveira EF
- Pankhurst NW
- Pelicice FM
- Pessanha ALM
- Poff NL
- Pouilly M
- Prado AVR
- Roa-Fuentes CA
- Rojas JE
- Rosenfeld J
- Sagnes P
- Santana CD
- Schlosser IJ
- Smouse PE
- Soares BE
- Sánchez RM
- Wainwright PC
- Ward-Campbell BMS
- Watson DJ
- Willis SC
- Winemiller KO
- Wood BM
- Wootton RJ
- Zúñiga-Upegui P
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
- Author
- Abdelrazik M
- Abedalthagafi M
- Abel L
- Abel L
- Abellan J
- Abernathy C
- Abraheem A
- Acklery A
- Acosta-Isaac R
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afolabi D
- Agasou A
- Agravante K
- Agravante K
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar PM
- Aguilera-Albesa S
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Moasseb H
- Alasdair F
- Alba J
- Albu S
- Alcalá-Gallardo KAM
- Alcoba-Florez J
- Aldridge J
- Alex B
- Alexander P
- Alfonso J
- Algarin-Lara HR
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allibone S
- Allison KS
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almeida J
- Almoguera B
- Alonso MR
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alves MDM
- Amamio M
- Amamio M
- Amin V
- Anastasescu E
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Andreou P
- Andreu-Bernabeu Á
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrikopoulos P
- Antcliffe D
- Antoine P
- Antonijoan MR
- Antony S
- Anumakonda V
- Anwer M
- Apetri E
- Aquino M
- Arana-Arri E
- Aranda C
- Arango C
- Araque C
- Araujo IMT
- Araujo NK
- Aravindan L
- Arbane G
- Arcanjo AC
- Archer K
- Arden T
- Arias SS
- Arif S
- Armistead J
- Armstrong D
- Armstrong L
- Armstrong R
- Arnaiz A
- Arnott A
- Arora M
- Arranz MJ
- Artiga M-J
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Aslibekyan S
- Astin-Chamberlain R
- Atayeva N
- Attwood B
- Atwal I
- Auld F
- Austin K
- Austin P
- Auton A
- Avello-Malaver Y
- Ayers A
- Ayuso C
- Bach B
- Badal B
- Baddeley A
- Bafitis V
- Baikady RR
- Bailey L
- Baillie JK
- Baillie JK
- Baillie K
- Baines D
- Baines K
- Baird T
- Baird Y
- Baker M
- Bakthavatsalam D
- Baldión-Elorza AM
- Bamford A
- Bamford A
- Bamford P
- Banach D
- Bancroft H
- Bandla N
- Bano S
- Baptista D
- Baptista-Rosas RC
- Barber R
- Barberis L
- Barberis L
- Barclay C
- Barclay L
- Barclay WS
- Barker J
- Barker M
- Barnes N
- Barr J
- Barranco-Díaz A
- Barreda-Sánchez M
- Barrera-Penagos V
- Barrett F
- Barron A
- Barrow E
- Barry P
- Bartley S
- Barton J
- Baruah R
- Bashyal A
- Basikolo C
- Bastion V
- Bates H
- Bates M
- Batres SA
- Battle C
- Bauchmuller K
- Baxter N
- Baxter-Dore S
- Bayo L-A
- Beadle J
- Bean S
- Beasley A
- Beaumont K
- Beavis S
- Beech E
- Beech V
- Beekes M
- Beer S
- Beesley K
- Begg C
- Behan T
- Beith C
- Beith C
- Belagodu Z
- Belfield H
- Belhassen-Garcia M
- Bell D
- Bell G
- Bell J
- Bell M
- Bell S
- Bellamy M
- Bellini A
- Bellwood R
- Bemand T
- Benham L
- Benito HG
- Benkenstein S
- Bennett S
- Bentley M
- Benyon S
- Beranova E
- Bercades G
- Bernal E
- Bernal-Bello D
- Bevan E
- Bewley J
- Bezerra JF
- Bezerra MAC
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bi R
- Bibi F
- Biddle J
- Biggs H
- Birch J
- Birch J
- Birch S
- Birch S
- Birchall K
- Birchall K
- Bircham S
- Bird S
- Birkinshaw I
- Birt M
- Birt M
- Bishop L
- Biss J
- Black C
- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanca-López N
- Blancas R
- Bland Y
- Blow S
- Blowing H
- Blunt M
- Board S
- Bociek A
- Bogaert D
- Boix-Palop L
- Bokhari M
- Bolger A
- Bolger C
- Bolton M
- Bolton R
- Boltwood K
- Bonner S
- Bonnici J
- Booker L
- Borislavova B
- Borja AL
- Borobia A
- Borra C
- Botello A
- Botfield D
- Botfield L
- Bough L
- Bowes A
- Bowey A
- Bowles R
- Bowman F
- Boxall H
- Boyd E
- Boyer N
- Boyle P
- Boyle R
- Boz C
- Bradley C
- Bradley P
- Bradley-Potts J
- Bradley-Potts J
- Bradshaw Z
- Brady A
- Brady L
- Brady M
- Brady R
- Brandwood C
- Brandwood C
- Branney D
- Bravo E
- Brayne A
- Brealey D
- Brealey D
- Brearey S
- Bremmer P
- Bretherick AD
- Brett M
- Brett S
- Brickell K
- Bridgett V
- Brimfield L
- Brinkworth E
- Brion M
- Briton K
- Briton K
- Brochado-Kith Ó
- Bromley M
- Brooke H
- Brooks J
- Brooks J
- Brooks S
- Brown A
- Brown A
- Brown A
- Brown CW
- Brown E
- Brown J
- Bruce M
- Brugada R
- Brunton M
- Bryant J
- Buckley C
- Buckley J
- Buckley S
- Bull R
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- Bunni L
- Burchett C
- Burda D
- Burgoyne A
- Burn I
- Burnett C
- Burnish R
- Burns K
- Burrow A
- Burt K
- Burtenshaw A
- Burton M
- Bustos M
- Butcher D
- Butler A
- Butler J
- Butler S
- Butt F
- Butterworth-Cowin N
- Button H
- Buttriss C
- Cabello A
- Cabral-Ortega L
- Cabrelli L
- Caceres-Agra JJ
- Cagova L
- Calbo E
- Calderón EJ
- Cale E
- Callaghan M
- Callam S
- Calvo CM
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- Campos S
- Camsooksai J
- Candalija AC
- Candon AM
- Capitán CF
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- Cardona-Huerta S
- Cardwell A
- Carioca AAF
- Carmody M
- Carmody S
- Carnahan M
- Carpintero MS
- Carracedo A
- Carracedo A
- Carratto TMT
- Carrera LG
- Carrillo-Avila JA
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- Cartlidge D
- Carungcong J
- Carvalho MCC
- Casasnovas C
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- Castano L
- Castaño CF
- Castaño JAT
- Castelao JE
- Castillo MA
- Caswell M
- Caterson J
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- Ceballos FC
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- Chablani M
- Chadwick R
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- Charlesworth R
- Charnock R
- Charris HM
- Chaux JG
- Chaves-Santiago WG
- Chechi K
- Cheema Y
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- Chetam L
- Cheyne C
- Chikowore P
- Childs D
- Chiquillo-Gómez S
- Chisholm C
- Choudhr O
- Choudhury Y
- Chukkambotla S
- Chávez MEQ
- Cid-Lopez MA
- Cienfuegos-Jimenez O
- Cinquina Z
- Clamp S
- Clapham M
- Clarey E
- Claridge H
- Clark A
- Clark A
- Clark M
- Clark M
- Clark R
- Clark R
- Clark S
- Clark S
- Clark V
- Clarke N
- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clohisey S
- Coates C
- Cochrane P
- Cockerill H
- Cockrell M
- Coe R
- Coetzee S
- Coghlan P
- Cohrane C
- Coker D
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- Collins A
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- Collis M
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- Conde-Vicente R
- Conejo IP
- Connell J
- Connolly K
- Connor M
- Convery K
- Conyngham J-A
- Cooke GS
- Cookson R
- Cooper J
- Cooper L
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- Corcoran E
- Corcoran K
- Cordero-Lorenzana ML
- Corella D
- Corin C
- Cornell S
- Cornell T
- Corner A
- Corral MA
- Corrales A
- Cortes-Sanchez JL
- Corton M
- Cosgrove D
- Cosier T
- Costa TX
- Cother N
- Coton Z
- Cottam L-J
- Cottle J
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- Coventry T
- Covernton P
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- Cuerda VM
- Cuesta L
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- da Silva Filipe A
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- Daglish J
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- de Bustamante AD
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- de Heredia ML
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- de la Horra C
- de la Hoz AB
- De Martino-Rodríguez A
- de Neef M
- De Queiroz JG
- de Quirós FGB
- de Silva T
- de Sousa Alves Neri JL
- Deacon B
- Deacon B
- Dean C
- Dearden J
- DeAth Y
- Debreceni G
- Deery J
- del Campo-Pérez V
- Dela Rosa A
- Delaney J
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- Dell A
- Demetriou C
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- Dennis C
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- Dexter C
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- Diaba C
- Diaz-Caneja CM
- Dickson H
- Dietl B
- Digby B
- Digby S
- Ding L
- Diz-de Almeida S
- Djeugam B
- Doble P
- Dobson E
- Docherty AB
- Dodd A
- Dodds S
- Dolan H
- Domingos P
- Domínguez-Garrido E
- Donaldson A
- Donaldson D
- Donegan C
- Donlon S
- Donnachie J
- Donne B
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- Doonan R
- Dore R
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- dos Santos Correia G
- dos Santos KA
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- Drummond A
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- Eastgate C
- Easthope A
- Easthope A
- Easthope A
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- Elbehery M
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- Elsaadany M
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- Emblem J
- Enciso-Olivera CO
- English K
- Eros A
- Escudero G
- Esparza-Gordillo J
- España PP
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- Fernandez-Nestosa MJ
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- Fernández-Robelo U
- Fernández-Rodríguez A
- Fernández-Sampedro M
- Fernández-Sánchez R
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- Ferrero SF
- Fidler K
- Filipe H
- Filshtein-Sonmez T
- Finch C
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- Fourman MH
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- Franke G
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- Fuentes CS
- Fumadó V
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- García M
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- García PM
- García-de-Vicuña A
- García-García I
- García-Ibarbia C
- García-Montero AC
- García-Soidán A
- García-Vázquez E
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- Gellamucho M
- Gemmell L
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- Gnanapragasam P
- Goddard W
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- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
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