Semi-supervised URL Segmentation with Recurrent Neural Networks Pre-trained on Knowledge Graph Entities

Breaking domain names such as openresearch into component words open and research is important for applications like Text-to-Speech synthesis and web search. We link this problem to the classic problem of Chinese word segmentation and show the effectiveness of a tagging model based on Recurrent Neural Networks (RNNs) using characters as input. To compensate for the lack of training data, we propose a pre-training method on concatenated entity names in a large knowledge database. Pre-training improves the model by 33% and brings the sequence accuracy to 85%

Micropapillary Variant of Urothelial Carcinoma

Micropapillary carcinoma (MPC) of urinary tract is an uncommon variant of urothelial carcinoma with significant diagnostic and prognostic implications. Though MPC shows characteristic microscopic features, there exists interobserver variability and also it needs to be differentiated from the metastasis from other organs. The prognosis is generally poor, depending on the proportion of the micropapillary component in some reports. Early cystectomy in cases with only lamina propria invasion may be indicated according to recent studies. This review outlines the general features of this entity and briefly comments on the controversies and the recent development

Pathologic Findings of Amyloidosis: Recent Advances

Amyloids are aggregations of misfolded protein, which creates fibrillary structures. Unlike normally folded proteins, misfolded fibrils are insoluble and deposited extracellularly or intracellularly. The pathologic mechanism is still unclear, but resultant toxic oligomers within the tissue are known to damage the tissue via aberrant protein interactions. This condition has been known as amyloidosis. Different kinds of amyloid protein may cause similar or different clinical signs and symptoms, largely depending on the target organ it is deposited. However, because treatments and prognoses of each type are different drastically, it is critical to distinguish them and determine the specific type of amyloidosis. The confirmation and typing of amyloid heavily depend on pathologic examination of tissue. The gold standard method for the former is a Congo red staining and birefringence under polarized microscopy. The conventional way for the latter is immunohistochemistry (IHC), where most of the amyloid types can be classified. However, electron microscopy, mass spectrometry, or other molecular methods are required for typing some amyloids that are difficult to identify through IHC. In this chapter, we will describe basic concepts of amyloidosis and pathologic findings of amyloid deposition, including atypical structural deposition. Furthermore, we will review methodologies for amyloid typing briefly

Westward-propagating SST Anomalies and Baroclinic Eddies in the Sargasso Sea

Previous studies have documented the existence of a zonal band of strong, persistent, westward-propagating sea surface temperature (Ts) anomalies with zonal wavelengths of ≈800 km and periods of ≈200 days that are confined to the subtropical convergence zone (STCZ, roughly 26°–32°N). Two years of satellite-derived sea surface temperature (Ts) and sea surface elevation anomaly (η) maps of the Sargasso Sea (22.5°–33.5°N, 71.5°–59.5°W) are analyzed to determine how these anomalies are forced and why they an confined to the STCZ. A simple anomaly model forced by horizontal eddy currents and damped by a linear feedback mechanism explains many properties of the anomaly response. At wavelengths exceeding several hundred kilometers, forcing by horizontal eddy currents becomes less important relative to atmospheric forcing with increasing wavelength. The anomalies are confined to the STCZ partly because the large mean Ts gradient there enables the horizontal eddy currents to be relatively effective at forcing anomalies. Also, the eddies that force these anomalies, wavelike features with wavelengths of ∼800 km and periods of ∼200 days, are themselves confined to the STCZ. These wavelike eddies were not detecting during earlier experiments such as MODE because the domains within which they were conducted were too small. Within the STCZ, zonal dispersion properties of the eddy field are consistent with baroclinic Rossby wave variability. To the north and south of the STCZ, however, zonal dispersion properties differ substantially from the properties observed within the STCZ. The eddy dispersion properties change abruptly across transition zones 1–2 degree wide centered at 32.5° and 25.5°N. A simple linearized reduced-gravity model is used to demonstrate that interaction between eddies and zonal mean currents can qualitatively account for the change is dispersion properties south of the STCZ, but not to the north within the Gulf Stream recirculation region

Chondrosarcoma: With Updates on Molecular Genetics

Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future