In situ particle size measurements during crystallization processes using image analysis

National audienceThe aim of this article is to present a new online image analysis based method for monitoring the Crystal Size Distribution (CSD) during batch solution crystallization processes. An in-situ imaging probe allows real time acquisition of 2D images of particles during the batch process. From these images, restoration and segmentation algorithms are performed in order to identify the particles. Thereafter, mathematical morphology enables to get geometrical and morphological particle measurements. Therefore, the CSD can be deduced all along the time of the crystallization process (until moderate solid concentration)

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Accès videotex a une banque de données médicales

Disponible dans les fichiers attachés à ce documen

Characterization of ice cream structure by direct optical microscopy. Influence of freezing parameters

International audienc

In situ monitoring of the droplet size distribution of o/w emulsion during the emulsification process

International audienc

Crystallization of Monohydrate Citric Acid. 1. In Situ Monitoring through the Joint Use of Raman Spectroscopy and Image Analysis

International audienceSeeded batch crystallizations of monohydrate citric acid were performed under isothermal conditions (15 degrees C). Continuous monitoring of the overall solid concentration during the crystallization process was developed using in situ Raman spectroscopy. Quantitative estimation of the crystal size distribution (CSD) was made possible thanks to in situ image acquisition: off-line CSD measurements were further computed from the recorded pictures. The growth rate of monohydrate citric acid was estimated from solid concentration. Through in situ particle size visualization and quantitative analysis of the pictures, activated surface secondary nucleation was also shown to significantly impact the final CSD. It is underlined that, in addition to continuous Raman in situ spectroscopic concentration measurements, image acquisition yields highly valuable data on the dispersed phase. Advantages and drawbacks of the technique for the monitoring of solution crystallization are discussed

Procédé de cristallisation en émulsion en réacteur agité : suivi vidéo in situ de l'évolution des distributions de tailles de gouttes et de particules

International audienc

In situ monitoring of the droplet size distribution of o/w emulsion during the emulsification process

International audienc

Procédé de formulation par cristallisation en émulsion : etude de la distribution en taille de gouttes par video in situ

International audienc