Persistence to an Associate of Applied Science Registered Nurse Degree: The Impact of Placing Into Developmental Education Courses on Student Success

Student retention and success in nursing school has gained favor in educational research due to an increasing shortage of Registered Nurses. The purpose of this study is to measure the impact of student placement recommendation into developmental education courses on persistence to an Associate of Applied Science Registered Nurse degree. Using ex post facto research methodology rooted in the retention theories of Tinto, Bean and Metzner, and Jeffreys, this study aims to measure the effect of high school diploma type, age, race/ethnicity, and pre-requisite courses on student placement recommendation in developmental education and persistence to an Associate of Applied Science Registered Nurse degree. This inquiry attempts to fill a gap in the scholarly literature focused on community college Registered Nurse program student retention, specifically in studying the likelihood of success for under-prepared students in nursing programs

Lung Cancer Stem Cell: New Insights on Experimental Models and Preclinical Data

Lung cancer remains the leading cause of cancer death. Understanding lung tumors physiopathology should provide opportunity to prevent tumor development or/and improve their therapeutic management. Cancer stem cell (CSC) theory refers to a subpopulation of cancer cells, also named tumor-initiating cells, that can drive cancer development. Cells presenting these characteristics have been identified and isolated from lung cancer. Exploring cell markers and signaling pathways specific to lung CSCs may lead to progress in therapy and improve the prognosis of patients with lung cancer. Continuous efforts in developing in vitro and in vivo models may yield reliable tools to better understand CSC abilities and to test new therapeutic targets. Preclinical data on putative CSC targets are emerging by now. These preliminary studies are critical for the next generation of lung cancer therapies

Índice de las enfermedades respiratorias de los teleoperadores de la empresa konecta bto S.L. sucursal en Perú, en la sede de Bellavista – Callao en el año 2018

La presente investigación tiene por objetivo determinar el índice de enfermedades respiratorias en los teleoperadores de la empresa Konecta BTO S.L. Sucursal en Perú de la sede Bellavista. Callao, corresponde a una investigación descriptiva, de nivel puro, con una perspectiva cuantitativa, a través del empleo de datos. El diseño del estudio es no experimental de tipo transeccional. El universo de la población se constituye de 93 colaboradores que pertenecen al área de Claro Chile Televentas en la empresa Konecta BTO de la sede Bellavista. La muestra fue realizada mediante la técnica de muestreo aleatorio simple, estableciéndose 75 trabajadores.The objective of this research is to determine the rate of respiratory diseases in the teleoperators of the company Konecta BTO S.L. Branch in Peru of the Bellavista headquarters. Callao corresponds to a descriptive research, pure level, with a quantitative perspective, through the use of data. The design of the study is non-experimental of the transectional type. The universe of the population consists of 93 employees who belong to the Claro Chile Telesales area in the company Konecta BTO of the Bellavista headquarters. The sample was made using the simple random sampling technique, establishing 75 workers

A mediastinal germ cell tumor mimicking an ectopic pregnancy

The objective is to report the case of a 36 year-old female with a primary mediastinal germ cell tumor mimicking an ectopic pregnancy. The patient under birth control pill presented, at seven weeks of amenorrhea, a β-human chorionic gonadotropin (β-hCG) level of 850 UI and uterine vacuity with left lateral uterine heterogeneous mass but no bleeding and no pain. She received left adnexectomy, uterine curettage and further treatment by methotrexate because of persistent high β-hCG markers. Computed tomography scan finally permitted to discover a voluminous anterior mediastinal tumor. We may recommend investigating patients with a simple chest X-ray that present with persistent increased β-hCG despite efficient ectopic pregnancy treatment

Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis

Endometriosis is a chronic inflammatory disorder in which endometrial tissue is found outside the uterine cavity. Previous reports suggest that there is a dysregulation of the hypothalamic pituitary adrenal axis during the progression of endometriosis. Our previous report showed that a short-term treatment with antalarmin, a corticotrophin releasing hormone receptor type 1 (CRHR1) antagonist decreases the number and size of endometriotic vesicles in the auto-transplantation rat model of endometriosis. Our current goal was to examine the mRNA expression of intra-adrenal receptors to better understand the mechanisms of the hypothalamic pituitary adrenal (HPA) axis involvement in endometriosis. We used two groups of female rats. The first received sham surgery or endometriosis surgery before collecting the adrenals after 7 days of the disease progression. The second group of animals received endometriosis surgery and a treatment of either vehicle or antalarmin (20 mg/kg, i. p.) during the first 7 days after endometriosis induction and then the disease was allowed to progress until day 60. Rats with sham surgery served as controls. Results showed that the mRNA expression of the mineralocorticoid (MRC2) receptor was lower in the rats after 7 days of endometriosis surgery and in rats with endometriosis that received antalarmin. In addition, the CRHR1 was significantly elevated in animals that received antalarmin and this was counteracted by a non-significant elevation in CRHR2 mRNA. The glucocorticoid receptor mRNA within the adrenals was not affected by endometriosis or antalarmin treatment. This report is one of the first to explore intra-adrenal mRNA for receptors involved in the HPA axis signaling as well as in the sympatho-adrenal signaling, calling for additional research towards understanding the role of the adrenal glands in chronic inflammatory diseases such as endometriosis

Rooftop Solar Photovoltaics: The Untapped Potential of Commercial and Industrial Buildings

Professional paper for the fulfillment of the Master of Public Policy and Master of Urban and Regional Planning programs

Tratamento de casos de abuso infantil em Porto Rico: relação eficiente e eficaz?

Aim: to address the phenomenon of child abuse in Puerto Rico from a critical look towards the Government after the implementation of strategies to work with intervention processes, analyzing how the Department of the Family (DF), the Division of the Administration of Families and Children (ADFAN) and the laws that make up the public policy on the matter have been constituted. Results: the measures taken by the Government of Puerto Rico under different leaders, both belonging to the DPP and the PNP, did not show to be effective nor did they decrease the incidence of cases of abuse on the island. Conclusions: the work carried out by the DF and ADFAN is essential for the intervention processes, although a more human and multidisciplinary approach is necessary, one in which the health professionals can work with the family as an integrated system where the human being has a meaning, recognizing their parents as a fundamental part of themselves.Objetivo: abordar el fenómeno del maltrato de menores en Puerto Rico desde una mirada crítica hacia el gobierno después de la implementación de estrategias para trabajar con los procesos de intervención, analizando cómo se ha constituido el Departamento de la Familia (DF), la División de la Administración de Familias y Niños (ADFAN) y las leyes que conforman la política pública de éste. Resultados: las medidas que ha tomado el gobierno de Puerto Rico bajo los diferentes líderes, tanto del PPD como el PNP, no mostraron ser efectivas y no disminuyeron la incidencia de los casos de maltrato en la isla. Conclusiones: la labor del DF y ADFAN son indispensables para los procesos de intervención, aunque urge un acercamiento más humano con enfoque multidisciplinario, en el que los profesionales de la salud puedan trabajar con la familia como un sistema integrado donde el ser humano se significa, reconociendo a los padres como parte fundamental del mismo.Objetivo: abordar o fenômeno do abuso de crianças em Porto Rico partindo desde um olhar crítico ao governo depois da implementação de estratégias para trabalhar com os processos de intervenção, analisando Como se tem constituído o departamento da família (DF) a divisão da administração de famílias e crianças (ADFN) e as leis que conformam a política pública deste. Resultados: As medidas tomadas pelo governo de Porto Rico sob diferentes lideres, tanto o PPD como o PNP, não mostraram ser efetivas e não diminuíram a incidência dos casos de abuso na ilha. Conclusões: o trabalho do DF e do ADFAN é indispensável para os processos de intervenção, mas precisa-se com urgência de um enfoque mais humano com abordagem multidisciplinar, no qual os profissionais da saúde possam trabalhar com a família como um sistema integrado onde o ser humano pode achar sentido, reconhecendo aos pais como parte fundamental do mesmo

A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria.

Extracellular electron transfer (EET) describes microbial bioelectrochemical processes in which electrons are transferred from the cytosol to the exterior of the cell1. Mineral-respiring bacteria use elaborate haem-based electron transfer mechanisms2-4 but the existence and mechanistic basis of other EETs remain largely unknown. Here we show that the food-borne pathogen Listeria monocytogenes uses a distinctive flavin-based EET mechanism to deliver electrons to iron or an electrode. By performing a forward genetic screen to identify L. monocytogenes mutants with diminished extracellular ferric iron reductase activity, we identified an eight-gene locus that is responsible for EET. This locus encodes a specialized NADH dehydrogenase that segregates EET from aerobic respiration by channelling electrons to a discrete membrane-localized quinone pool. Other proteins facilitate the assembly of an abundant extracellular flavoprotein that, in conjunction with free-molecule flavin shuttles, mediates electron transfer to extracellular acceptors. This system thus establishes a simple electron conduit that is compatible with the single-membrane structure of the Gram-positive cell. Activation of EET supports growth on non-fermentable carbon sources, and an EET mutant exhibited a competitive defect within the mouse gastrointestinal tract. Orthologues of the genes responsible for EET are present in hundreds of species across the Firmicutes phylum, including multiple pathogens and commensal members of the intestinal microbiota, and correlate with EET activity in assayed strains. These findings suggest a greater prevalence of EET-based growth capabilities and establish a previously underappreciated relevance for electrogenic bacteria across diverse environments, including host-associated microbial communities and infectious disease