Política, religión y libertad en Augusto Del Noce y Erik Peterson

This work explores coincidences between two authors who have rarely been connected: Erik Peterson and Augusto Del Noce. Departing from theology and philosophy respectively, they both discover in the sacralization of power the degeneration of politics, far from how it should be conceived in a Christian way. They reach out to Augustine to apply his distinction between the two cities, in order to prevent an immanentization of the eschatological and a subjugation of personal freedom. The reflection on martyrdom and testimony in the democratic game offer a suggestive cooperation, respectful of the search and personal attachment to the truth, not conceiving politics as an intrinsic conflict.Este trabajo explora coincidencias entre dos autores que rara vez han sido puestos en relación: Erik Peterson y Augusto Del Noce. Desde la teología y la filosofía respectivamente, alcanzan ambos a ver en la sacralización del poder la degeneración de la política, alejada de cómo debería ser entendida cristianamente. Acuden a San Agustín para servirse de la distinción entre las dos ciudades para no caer en una inmanentización de lo escatológico y en un avasallamiento de la libertad de la persona. La reflexión sobre el martirio y el testimonio en el juego democrático ofrecen una sugestiva cooperación, respetuosa de la búsqueda y de la adhesión personal a la verdad, sin concebir a la política como una intrínseca confrontación

Avaliação regional de linhagens de feijoeiro comum do grupo preto no norte do Espírito Santo.

Este estudo tem por objetivo divulgar os resultados dos ensaios de VCU?s de 11 genótipos de feijoeiro do grupo preto, conduzidos nos anos de 2013 e 2014 no estado do Espírito Santo.CONAF

Avaliação de linhagens de feijoeiro comum no tabuleiro costeiro do Espírito Santo.

Este trabalho tem o objetivo de divulgar os resultados dos Testes de Adaptação Local, sob a responsabilidade do Instituto Capixaba de Pesquisa, Assistência Técnica e Extensão Rural (INCAPER), conduzidos na região dos tabuleiros costeiros do Espírito Santo no período de 2010 a 2012.CONAF

Avaliação de linhagens de feijoeiro comum de grãos carioca no norte do Espírito Santo.

Este estudo tem por objetivo divulgar os resultados dos ensaios de VCU?s de 14 genótipos de feijoeiro do grupo comercial carioca, conduzidos no ano de 2013 e 2014 no Estado do Espírito Santo.CONAF

Avaliação de linhagens de feijoeiro comum no Estado do Espírito Santo no período de 2008 a 2009.

Esse trabalho tem por objetivo divulgar os resultados dos ensaios de Teste de Adaptação Local, conduzidos sob a responsabilidade do Instituto Capixaba de Pesquisa, Assistência Técnica e Extensão Rural (INCAPER), no Espírito Santo no período de 2008 a 2009.CONAF

Avaliação de linhagens de feijoeiro comum no Estado do Espírito Santo no período de 2008 a 2009.

CONAFE

Cortical signatures of sleep are altered following effective deep brain stimulation for depression

Deep brain stimulation (DBS) of the subcallosal cingulate cortex (SCC) is an experimental therapy for treatment-resistant depression (TRD). Chronic SCC DBS leads to long-term changes in the electrophysiological dynamics measured from local field potential (LFP) during wakefulness, but it is unclear how it impacts sleep-related brain activity. This is a crucial gap in knowledge, given the link between depression and sleep disturbances, and an emerging interest in the interaction between DBS, sleep, and circadian rhythms. We therefore sought to characterize changes in electrophysiological markers of sleep associated with DBS treatment for depression. We analyzed key electrophysiological signatures of sleep—slow-wave activity (SWA, 0.5–4.5 Hz) and sleep spindles—in LFPs recorded from the SCC of 9 patients who responded to DBS for TRD. This allowed us to compare the electrophysiological changes before and after 24 weeks of therapeutically effective SCC DBS. SWA power was highly correlated between hemispheres, consistent with a global sleep state. Furthermore, SWA occurred earlier in the night after chronic DBS and had a more prominent peak. While we found no evidence for changes to slow-wave power or stability, we found an increase in the density of sleep spindles. Our results represent a first-of-its-kind report on long-term electrophysiological markers of sleep recorded from the SCC in patients with TRD, and provides evidence of earlier NREM sleep and increased sleep spindle activity following clinically effective DBS treatment. Future work is needed to establish the causal relationship between long-term DBS and the neural mechanisms underlying sleep

Dynamic Functional Connectivity Predicts Treatment Response to Electroconvulsive Therapy in Major Depressive Disorder

Background: Electroconvulsive therapy (ECT) is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging (rs-fMRI). This study aims to compare rs-fMRI of depressive disorder (DEP) patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network (dFNC) estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states. Method: Resting-state functional magnetic resonance imaging (fMRI) data were collected from 119 patients with depression or depressive disorder (DEP) (76 females), and 61 healthy (HC) participants (34 females), with an age mean of 52.25 (N = 180) years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale (HDRS) were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode (DMN) and cognitive control network (CCN) were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants. Results: The main findings include (1) depressive disorder (DEP) patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network (CCN) and default mode network (DMN) was relatively higher than other states (corrected p = 0.015), (2) Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes (R = 0.23 corrected p = 0.03). This means that those DEP patients who spent less time in this state showed more HDRS change, and (3) The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2 (corrected p = 0.03). Conclusion: Our finding suggests that dynamic functional network connectivity (dFNC) features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients

Development of the Ketamine Side Effect Tool (KSET)

Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture acute and longer-term side effects associated with repeated ketamine treatments. Methods: Informed by systematic review data and clinical research, we drafted a list of the most commonly reported side effects. Face and content validation were obtained via feedback from collaborators with expertise in psychiatry and anaesthetics, clinical trial piloting and a modified Delphi Technique involving ten international experts. Results: The final version consisted of four forms that collect information at time points: screening, baseline, immediately after a single treatment, and longer-term follow-up. Instructions were developed to guide users and promote consistent utilisation. Limitations: Further evaluation of feasibility, construct validity and reliability is required, and is planned across multiple international sites. Conclusions: The structured Ketamine Side Effect Tool (KSET) was developed, with confirmation of content and face validity via a Delphi consensus process. This tool is timely, given the paucity of data regarding ketamine's safety, tolerability and abuse potential over the longer term, and its recent adoption internationally as a clinical treatment for depression. Although based on data from depression studies, the KSET has potential applicability for ketamine (or derivatives) used in other medical disorders, including chronic pain. We recommend its utilisation for both research and clinical scenarios, including data registries