667 research outputs found
Application de la méthode de rétrodiffusion des électrons à la mesure en continu des faibles épaisseurs de revêtements légers sur métaux ou alliages légers
Le problème envisagé concerne la mesure en continu des faibles épaisseurs de revêtements organiques sur métaux ou alliages légers. Nous étudions les caractéristiques d'une jauge à rétrodiffusion β opérant sous atmosphère d'hélium. Nous montrons que le fait de travailler sous hélium améliore les résultats de façon très importante. L'influence de l'énergie de la source radio-active et du numéro atomique du revêtement sont examinés. Les résultats obtenus concernent également la précision, le temps de mesure ainsi que la surface de l'échantillon sous investigation
Dominant B-cell epitopes from cancer/stem cell antigen SOC2 recognized by serum samples from cancer patients
Cataloged from PDF version of article.Human sex determining region Y-box 2 (SOX2) is an important transcriptional factor involved in the pluripotency
and stemness of human embryonic stem cells. SOX2 plays important roles in maintaining cancer stem cell activities
of melanoma and cancers of the brain, prostate, breast, and lung. SOX2 is also a lineage survival oncogene
for squamous cell carcinoma of the lung and esophagus. Spontaneous cellular and humoral immune responses
against SOX2 present in cancer patients classify it as a tumor-associated antigen (TAA) shared by lung cancer, glioblastoma,
and prostate cancer among others. In this study, B-cell epitopes were predicted using computer-assisted
algorithms. Synthetic peptides based on the prediction were screened for recognition by serum samples from cancer
patients using ELISA. Two dominant B-cell epitopes, SOX2:52-87 and SOX2:98-124 were identified. Prostate
cancer, glioblastoma and lung cancer serum samples that recognized the above SOX2 epitopes also recognized
the full-length protein based on Western blot. These B-cell epitopes may be used in assessing humoral immune
responses against SOX2 in cancer immunotherapy and stem cell-related transplantation
Pseudo-time Schroedinger equation with absorbing potential for quantum scattering calculations
The Schroedinger equation with an energy-dependent complex absorbing
potential, associated with a scattering system, can be reduced for a special
choice of the energy-dependence to a harmonic inversion problem of a discrete
pseudo-time correlation function. An efficient formula for Green's function
matrix elements is also derived. Since the exact propagation up to time 2t can
be done with only t real matrix-vector products, this gives an unprecedently
efficient scheme for accurate calculations of quantum spectra for possibly very
large systems.Comment: 9 page
Norm estimates of complex symmetric operators applied to quantum systems
This paper communicates recent results in theory of complex symmetric
operators and shows, through two non-trivial examples, their potential
usefulness in the study of Schr\"odinger operators. In particular, we propose a
formula for computing the norm of a compact complex symmetric operator. This
observation is applied to two concrete problems related to quantum mechanical
systems. First, we give sharp estimates on the exponential decay of the
resolvent and the single-particle density matrix for Schr\"odinger operators
with spectral gaps. Second, we provide new ways of evaluating the resolvent
norm for Schr\"odinger operators appearing in the complex scaling theory of
resonances
Numerical Solution of the Time Dependent 3D Schrödinger Equation Describing Tunneling of Atoms from Anharmonic Traps
We present an efficient numerical method for the integration of the 3D Schrödinger equation. A tunneling problem of two interacting bosonic atoms confined in a 1D anharmonic trap has been successfully solved by means of this method. We demonstrate fast convergence of the final results with respect to spatial and temporal grid steps. The computational scheme is based on the operator-splitting technique with the implicit Crank-Nicolson algorithm on spatial sixth-order finite-differences. The computational time is proportional to the number of spatial grid points
Calmodulin content of rat mammary tissue and isolated cells during pregnancy and lactation
The association between real-life markers of phone use and cognitive performance, health-related quality of life and sleep
INTRODUCTION: The real-life short-term implications of electromagnetic fields (RF-EMF) on cognitive performance and health-related quality of life have not been well studied. The SPUTNIC study (Study Panel on Upcoming Technologies to study Non-Ionizing radiation and Cognition) aimed to investigate possible correlations between mobile phone radiation and human health, including cognition, health-related quality of life and sleep. METHODS: Adult participants tracked various daily markers of RF-EMF exposures (cordless calls, mobile calls, and mobile screen time 4 h prior to each assessment) as well as three health outcomes over ten study days: 1) cognitive performance, 2) health-related quality of life (HRQoL), and 3) sleep duration and quality. Cognitive performance was measured through six "game-like" tests, assessing verbal and visuo-spatial performance repeatedly. HRQoL was assessed as fatigue, mood and stress on a Likert-scale (1-10). Sleep duration and efficiency was measured using activity trackers. We fitted mixed models with random intercepts per participant on cognitive, HRQoL and sleep scores. Possible time-varying confounders were assessed at daily intervals by questionnaire and used for model adjustment. RESULTS: A total of 121 participants ultimately took part in the SPUTNIC study, including 63 from Besancon and 58 from Basel. Self-reported wireless phone use and screen time were sporadically associated with visuo-spatial and verbal cognitive performance, compatible with chance findings. We found a small but robust significant increase in stress 0.03 (0.00-0.06; on a 1-10 Likert-scale) in relation to a 10-min increase in mobile phone screen time. Sleep duration and quality were not associated with either cordless or mobile phone calls, or with screen time. DISCUSSION: The study did not find associations between short-term RF-EMF markers and cognitive performance, HRQoL, or sleep duration and quality. The most consistent finding was increased stress in relation to more screen time, but no association with cordless or mobile phone call time
The dynamical Green's function and an exact optical potential for electron-molecule scattering including nuclear dynamics
We derive a rigorous optical potential for electron-molecule scattering
including the effects of nuclear dynamics by extending the common many-body
Green's function approach to optical potentials beyond the fixed-nuclei limit
for molecular targets. Our formalism treats the projectile electron and the
nuclear motion of the target molecule on the same footing whereby the dynamical
optical potential rigorously accounts for the complex many-body nature of the
scattering target. One central result of the present work is that the common
fixed-nuclei optical potential is a valid adiabatic approximation to the
dynamical optical potential even when projectile and nuclear motion are
(nonadiabatically) coupled as long as the scattering energy is well below the
electronic excitation thresholds of the target. For extremely low projectile
velocities, however, when the cross sections are most sensitive to the
scattering potential, we expect the influences of the nuclear dynamics on the
optical potential to become relevant. For these cases, a systematic way to
improve the adiabatic approximation to the dynamical optical potential is
presented that yields non-local operators with respect to the nuclear
coordinates.Comment: 22 pages, no figures, accepted for publ., Phys. Rev.
GoMiner: a resource for biological interpretation of genomic and proteomic data
We have developed GoMiner, a program package that organizes lists of 'interesting' genes (for example, under- and overexpressed genes from a microarray experiment) for biological interpretation in the context of the Gene Ontology. GoMiner provides quantitative and statistical output files and two useful visualizations. The first is a tree-like structure analogous to that in the AmiGO browser and the second is a compact, dynamically interactive 'directed acyclic graph'. Genes displayed in GoMiner are linked to major public bioinformatics resources
From spin liquid to magnetic ordering in the anisotropic kagome Y-Kapellasite Y3Cu9(OH)19Cl8: a single crystal study
Y3Cu9(OH)19Cl8 realizes an original anisotropic kagome model hosting a rich
magnetic phase diagram [M. Hering et al, npj Computational Materials 8, 1
(2022)]. We present an improved synthesis of large phase-pure single crystals
via an external gradient method. These crystals were investigated in details by
susceptibility, specific heat, thermal expansion, neutron scattering and local
muSR and NMR techniques. At variance with polycristalline samples, the study of
single crystals gives evidence for subtle structural instabilities at 33K and
13K which preserve the global symmetry of the system and thus the magnetic
model. At 2.1K the compound shows a magnetic transition to a coplanar (1/3,1/3)
long range order as predicted theoretically. However our analysis of the spin
wave excitations yields magnetic interactions which locate the compound closer
to the phase boundary to a classical jammed spin liquid phase. Enhanced quantum
fluctuations at this boundary may be responsible for the strongly reduced
ordered moment of the Cu2+, estimated to be 0.075muB from muSR
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