37 research outputs found
Carbon dioxide (CO2) emissions and adherence to Mediterranean diet in an adult population: the Mediterranean diet index as a pollution level index
Background Research related to sustainable diets is is highly relevant to provide better understanding of the impact
of dietary intake on the health and the environment.
Aim To assess the association between the adherence to an energy-restricted Mediterranean diet and the amount of
CO2
emitted in an older adult population.
Design and population Using a cross-sectional design, the association between the adherence to an energyreduced
Mediterranean Diet (erMedDiet) score and dietary CO2
emissions in 6646 participants was assessed.
Methods Food intake and adherence to the erMedDiet was assessed using validated food frequency questionnaire
and 17-item Mediterranean questionnaire. Sociodemographic characteristics were documented. Environmental
impact was calculated through greenhouse gas emissions estimations, specifically CO2
emissions of each participant
diet per day, using a European database. Participants were distributed in quartiles according to their estimated CO2
emissions expressed in kg/day: Q1 (≤2.01 kg CO2),
Q2 (2.02-2.34 kg CO2),
Q3 (2.35-2.79 kg CO2)
and Q4 (≥2.80 kg CO2).
Results More men than women induced higher dietary levels of CO2
emissions. Participants reporting higher consumption
of vegetables, fruits, legumes, nuts, whole cereals, preferring white meat, and having less consumption of red meat were mostly emitting less kg of CO2
through diet. Participants with higher adherence to the Mediterranean
Diet showed lower odds for dietary CO2
emissions: Q2 (OR 0.87; 95%CI: 0.76-1.00), Q3 (OR 0.69; 95%CI: 0.69-0.79) and
Q4 (OR 0.48; 95%CI: 0.42-0.55) vs Q1 (reference).
Conclusions The Mediterranean diet can be environmentally protective since the higher the adherence to the Mediterranean
diet, the lower total dietary CO2
emissions. Mediterranean Diet index may be used as a pollution level index.official Spanish InstitutionsCIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS)European Commission PI13/00673
PI13/00492
PI13/00272
PI13/01123
PI13/00462
PI13/00233
PI13/02184
PI13/00728
PI19/01226
PI19/00781
PI19/01560
Especial Action Project
European Research Council (ERC)
European Commission 340918La Caixa Foundation 2013ACUP00194Junta de Andalucia PI0458/2013
PS0358/2016
PI0137/2018Center for Forestry Research & Experimentation (CIEF)European Commission PROMETEO/2017/017SEMERGEN grantICREA under the ICREA Academia programmeCanadian Institutes of Health Research (CIHR) MFE171207
PI16/00533
PI16/00381
PI16/00366
PI16/01522
PI16/01120
PI17/00764
PI17/01183
PI17/00855
PI17/01347
PI17/00525
PI17/01827
PI17/00532
PI17/00215
PI17/01441
PI17/00508
PI17/01732
PI17/00926
PI19/00957
PI19/00386
PI19/00309
PI19/01032
PI19/00576
PI19/00017
PI20/01532
PI20/00456
PI20/00339
PI20/00557
PI20/00886
PI20/01158
PI16/01873
PI16/01094
PI16/00501
PI13/01090
PI13/01056
PI14/01722
PI14/00636
PI14/00618
PI14/00696
PI14/01206
PI14/01919
PI14/00853
PI14/01374
PI14/00972
PI14/00728
PI14/01471
PI16/00473
PI16/00662
PI19/01332
PI20/01802
PI20/0013
Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome
Funding sponsor Funding number Acronym
Balearic Islands Health Research InstituteEU-COST
35/2011, CA16112Fondo de Investigación para la SaludIDISBA
CB12/03, CIBEROBN CB06/03Margalida Comas
DG R+D+IMinistry of Science, SpainEuropean Commission
201630.10, EAT2BENICE_H2020_SFS2016European Research Council
2013–2018, 340918Generalitat Valenciana
PROMETEO/2017/017Instituto de Salud Carlos IIIFunding sponsor Funding number Acronym
Balearic Islands Health Research Institute
EU-COST
35/2011, CA16112
Fondo de Investigación para la Salud
IDISBA
CB12/03, CIBEROBN CB06/03
Margalida Comas
DG R+D+I
Ministry of Science, Spain
European Commission
See opportunities by EC
See opportunities (opens in new window) 201630.10, EAT2BENICE_H2020_SFS2016 EC
European Research Council
See opportunities by ERC
See opportunities (opens in new window) 2013–2018, 340918 ERC
Generalitat Valenciana
See opportunities by GVA
See opportunities (opens in new window) PROMETEO/2017/017 GVA
Instituto de Salud Carlos III
2013ACUP00194, PI13/00233, PI13/00272, PI13/00462, PI13/00492, PI13/00673, PI13/00728, PI13/01056, PI13/01090, PI13/01123, PI13/02184, PI14/00618, PI14/00636, PI14/00696, PI14/00728, PI14/00853, PI14/00972, PI14/01206, PI14/01374, PI14/01471, PI14/01722, PI14/01919, PI16/00366, PI16/00381, PI16/00473, PI16/00501, PI16/00533, PI16/00662, PI16/01094, PI16/01120, PI16/01522, PI16/01873, PI17/00215, PI17/00508, PI17/00525, PI17/00532, PI17/00764, PI17/00855, PI17/00926, PI17/01183, PI17/01347, PI17/01441, PI17/01732, PI17/01827, PI19/00017, PI19/00309, PI19/00386, PI19/00576, PI19/00781, PI19/00957, PI19/01032, PI19/01226, PI19/01332, PI19/01560, PI20/00138, PI20/00339, PI20/00456, PI20/00557, PI20/00886, PI20/01158, PI20/01532, PI20/01802Consejería de Salud y Familias, Junta de Andalucía
PI0137/2018, PI0458/2013, PS0358/201
Metabolic syndrome criteria and severity and carbon dioxide ( CO2) emissions in an adult population
Background Metabolic syndrome (MetS) has become a growing risk factor of some non-communicable diseases.
Increase of greenhouse gas emissions affects the planet.
Aims To assess the association between MetS severity and amount of carbon dioxide (
CO2) emitted in an adult population.
Design Cross-sectional study (n = 6646; 55-76-year-old-men; 60-75-year-old-women with MetS).
Methods Dietary habits were assessed using a pre-validated semi quantitative 143-item food frequency questionnaire.
The amount of CO2
emitted due to the production of food consumed by person and day was calculated using
a European database, and the severity of the MetS was calculated with the MetS Severity Score.
Results Higher glycaemia levels were found in people with higher CO2
emissions. The risk of having high severe
MetS was related to high CO2
emissions.
Conclusions Low CO2
emissions diet would help to reduce MetS severity. Advantages for both health and the environment
were found following a more sustainable diet.European Union (EU)Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grantEuropean Research Council (ERC)La Caixa FoundationJunta de AndaluciaCenter for Forestry Research & Experimentation (CIEF)SEMERGEN grantICREAJuan de la Cierva gran
Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients
Undercarboxylated osteocalcin (ucOC) could be a biomarker of glucose disturbances and cardiovascular
risk. Our study aimed to determine the association between serum levels of ucOC and cardiovascular
risk in metabolic syndrome (MetS) patients and to analyse its potential role as estimator of type 2
diabetes (T2D) risk in this population. This cross-sectional study included 235 patients with MetS,
53.2% women, aged 55–75 years. Circulating ucOC levels were measured by ELISA. Cardiovascular risk
was determined as Z-score of the diagnostic criteria for MetS (CV-ZS). Linear regression model was
performed to analyse the association between circulating ucOC and CV-ZS. A receiver operating curve
(ROC) was performed to analyse the usefulness of ucOC as T2D risk estimator. Patients above the CV-ZS
median showed signifcant lower ucOC levels. We found an inverse association between ucOC levels and
CV-ZS in MetS patients without T2D. Patients with ucOC levels below the 25th percentile showed worse
cardiometabolic profle and higher cardiovascular and T2D risk. The area under the curve performed
better when ucOC levels were included along with the classic T2D risk factors. The measurement of
circulating ucOC could be a useful tool to identify increased cardiovascular and T2D risk in MetS patients
without T2D.Junta de Andalucia
PI-0207-2016European Union (EU)
PI18-00803
PI18-0123
Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial
This study was cofounded by grants from the Spanish Ministry of Science-Instituto de Salud
Carlos III (PI17/00764) and FEDER funds. The authors wish to thank Ingrid de Ruiter, MBChB, Ph.D., for English
language support.The purpose of this study is to evaluate the effect of a Mediterranean diet supplemented with
extra virgin olive oil and nuts on dry eye parameters. The participants in this study were randomized
into one of the two interventional arms: (1) a standard intervention group, a Mediterranean diet
supplemented with extra virgin olive oil and nuts; and (2) an intensive intervention group, based
on a hypocaloric Mediterranean diet and an intensive lifestyle program with physical activity and
weight-loss goals. In both groups, common dry eye tests were conducted at baseline and after six
months: the Ocular Surface Disease Index (OSDI), the Dry Eye Scoring System (DESS), tear break-up
time (TBUT), the Schirmer’s test, and the Oxford staining grade. Sixty-seven eyes were examined.
After six months, dry eye parameters improved in both groups; differences between groups were
favorable for the intensive intervention group. The implementation of a Mediterranean diet pattern
was beneficial for the selected patients with dry eye, and could be beneficial for patients with dry eye
in general. Behavioral support for diet adherence and the promotion of healthy lifestyles (exercise)
and weight loss (calorie restriction) have an added positive effect.Instituto de Salud Carlos III
Spanish Government
PI17/00764European Union (EU
Las diferencias en los síntomas psicológicos durante el embarazo y el postparto antes y después del COVID-19: un estudio transversal
Pregnant women are especially vulnerable to mental health problems, including stress, anxiety, and depression. This risk has been increased during the COVID-19 pandemic and differences in psychological symptoms in pregnancy and postpartum before and during COVID-19 exists. Mental health problems can have adverse effects on both the woman, and the neonate, including miscarriages, premature births, low birth weight, and higher rates of cesarean sections and instrument-assisted deliveries. Aim: To evaluate the prevalence of psychological symptoms of pregnant women before and during the COVID-19 pandemic. Method: A cross-sectional study was carried out to assess the psychological profile in a sample of pregnant women selected before the pandemic and a sample of women studied during the first wave of the pandemic. A total of 122 women were selected prior to the pandemic and 181 women during the COVID-19 outbreak. The Symptom Checklist-90 Revised (SCL-90-R) was used to assess depression and anxiety during pregnancy and in the postpartum period. Results: The prevalence of symptoms of depression and anxiety during pregnancy were higher in the sample of women studied during the pandemic (SCL-90-R: M = 54.6 vs. 42.6 and M = 62.6 vs. 51.7 respectively). In the postpartum the difference between both samples of women was even higher for depression and anxiety (SCL-90-R: M = 50.4 vs. 35.0 and M = 51.3 vs. 36.0 respectively). Being a pregnant woman at the COVID-19 outbreak was directly associated with a higher score of depression symptoms (aOR = 8.67, 95% CI [3.26, 23.02], p < .001). Anxiety during childbirth was more frequently reported by women before the pandemic (aOR = 5.13, 95% CI [2.53, 10.44], p < .001). The variable stage (before /during pandemic) was also associated with having a clinical SCL-90-R score above 70 (aOR = 7.61, 95% CI [2.7, 21.47], p < .001). Conclusion: During the pandemic, pregnancy and postpartum were associated with the presence of anxiety and depression. The main factor associated with postpartum depression was maternal age. These finding highlights the vulnerability of pregnant in front of the pandemic, in which psychological health and mental well-being are affected, not only during pregnancy, but also in the postpartum.Las mujeres embarazadas son especialmente vulnerables a los problemas de salud mental, como el estrés, la ansiedad y la depresión. Este riesgo se ha incrementado durante la pandemia de COVID-19, habiendo diferencias en los síntomas psicológicos en el embarazo y el puerperio antes y después de la pandemia. Los problemas de salud mental pueden tener efectos perjudiciales tanto en la mujer como en el recién nacido, como abortos espontáneos, partos prematuros, bajo peso al nacer y tasas más altas de cesáreas y partos asistidos. Objetivo: Evaluar la prevalencia de síntomas psicológicos de gestantes antes y durante la pandemia de COVID-19. Método: Se realizó un estudio transversal para evaluar el perfil psicológico en una muestra de mujeres embarazadas seleccionadas antes de la pandemia y una muestra de mujeres estudiadas durante la primera ola de la pandemia. Se seleccionó un total de 122 mujeres antes de la pandemia y 181 mujeres durante el brote de COVID-19. Se utilizó la Inventario de Verificación de Síntomas-90 Revisada (SCL-90-R) para evaluar la depresión y la ansiedad durante el embarazo y el puerperio. Resultados: La prevalencia de síntomas de depresión y ansiedad
durante el embarazo fue mayor en la muestra de mujeres estudiadas durante la pandemia (SCL-90-R: M = 54.6 vs. 42.6 y M =
62.6 vs. 51.7 respectivamente). En el postparto la diferencia entre ambas muestras de mujeres fue aún mayor para depresión
y ansiedad (SCL-90-R: M = 50.4 vs. 35.0 y M = 51.3 vs. 36.0 respectivamente). Ser mujer embarazada en el brote de COVID-19
se asoció directamente con una mayor puntuación de síntomas de depresión (aOR = 8.67, IC 95% [3.26, 23.02, p < .001).
Las mujeres manifestaron ansiedad durante el parto con mayor frecuencia antes de la pandemia (aOR = 5.13, IC 95% 2.53,
10.44], p < .001). La variable estadio (antes/durante la pandemia) también se asoció con tener una puntuación clínica SCL-
90-R superior a 70 (aOR = 7.61, IC 95% [2.7, 21.47], p < .001). Conclusión: Durante la pandemia, el embarazo y el postparto se
asociaron con la presencia de ansiedad y depresión. El principal factor asociado a la depresión posparto fue la edad materna.
Estos hallazgos resaltan la vulnerabilidad de las mujeres embarazadas ante la pandemia, en la que la salud psicológica y el
bienestar mental se ven afectados, no solo durante el embarazo, sino también en el posparto.Junta de Andalucía (RH-0069-2021)
Risk Factors for Post-Traumatic Stress Disorder after Childbirth: A Systematic Review
Background: Post-traumatic stress disorder (PTSD) after birth has generated a growing
interest in recent years. Although some risk factors associated with PTSD have been studied, information
is still scarce to date on risk factors associated with PTSD. This systematic review aims to
identify risk factors associated with the diagnosis of PTSD after childbirth. Methods: We searched on
PubMed,Web of Science and SCOPUS databases, from inception to May 2022. Quality assessment
of the articles was performed using the Newcastle-Ottawa Quality Assessment (“NOQAS”) scale.
This systematic review was performed according to the PRISMA guidelines. Inclusion criteria were
women with age 18 years; articles in English or Spanish; articles focused on physical, social, psychological,
medical-obstetric, and environmental risk factors. Results: A total of n = 17,675 women
were included among the studies in this systematic review. The main risk factors associated with
PTSD after birth were obstetric interventions and obstetric violence such as emergency caesarean
section or a non-compliant birth plan, a previous mental illness, having suffered from of a traumatic
event or depression and/or anxiety, and having poor social support throughout pregnancy and/or
during birth. Conclusions: Obstetric interventions, obstetric violence, experiencing a traumatic event
or depression and/or anxiety, and a previous mental illness are factors associated with the diagnosis
of PTSD after birth. Protective factors are multiparity, adherence to the mother’s birth plan and
skin-to-skin contact.Junta de Andalucia RH-0069-202
Exploring the Role of Sclerostin as a Biomarker of Cardiovascular Disease and Mortality: A Scoping Review
Sclerostin is most recognized for its role in controlling bone formation; however, it is also
expressed in the heart, aorta, coronary, and peripheral arteries. Human studies have associated high
circulating sclerostin levels with the presence of different cardiovascular diseases (CVD), surrogate
CVD markers, and a high risk of cardiovascular events in some populations. However, this is still a
matter of scientific debate, as the results have been very heterogeneous among studies. In the present
review, the association between serum sclerostin levels and CVD and/or cardiovascular mortality
was analyzed. For this purpose, a scoping review was performed in which articles measuring serum
sclerostin levels and cardiovascular risk in patients were selected. Eleven articles answered the
research question; of these articles, 8/11 evaluated the association between sclerostin and CVD, of
which 4/8 found a positive association, 2/8 found a negative association, and 2/8 found no association
between variables. Five (5/11) of the articles included in the study evaluated cardiovascular
mortality, of which 3/5 found a positive association, 1/5 found a negative association, and 1/5
found no association between variables. In conclusion, we did not find sufficient results to be able to
demonstrate an association between elevated sclerostin levels and the development of CVD and/or
cardiovascular mortality in the general population due to heterogeneity in the results. However, there
seems to be a tendency to consider increased sclerostin levels as a risk factor for both the development
of cardiovascular events and cardiovascular mortality in specific populations. Further studies in this
field will help to solve some of the inconsistencies found during this scoping review and allow for the
future use of sclerostin measurement as a strategy in the prevention and diagnosis of CVD and/or
cardiovascular mortality.Instituto de Salud Carlos III
European Commission PI18-00803
PI21/01069
PI18-01235
CD20/00022European CommissionJunta de Andalucia PI-0268-2019
RH-0069-2021Instituto de Salud Carlos IIIUniversity of Granada FI19/00118European Commission 811
Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study
Lifestyle changes are causing an exponential increase in the prevalence of obesity and
metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development
of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the
cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone
metabolism have been associated with CVR. The aim of this study was to determine the levels of
undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association
with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was
conducted in which a MetS population was followed for one year. Weight change, adherence to the
Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was
calculated using different scores. Our results showed a decrease of CVR associated with a better
adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of
MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS
population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels
could be good predictors of T2D prevalence.Instituto de Salud Carlos III
European Commission PI18-00803
PI21/01069
PI18-01235
FI19/00118
CD20/00022European CommissionJunta de Andalucia CD20/00022
PI-0268-2019
RH-0069202