38 research outputs found

    A Primary Role for Golgi Positioning in Directed Secretion, Cell Polarity, and Wound Healing

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    Peri-centrosomal positioning of the mammalian Golgi apparatus is known to involve microtubule-based motility, but its importance for cellular physiology is a major unanswered question. Here, we identify golgin-160 and GMAP210 as proteins required for centripetal motility of Golgi membranes. In the absence of either golgin, peri-centrosomal positioning of the Golgi apparatus was disrupted while the cytoskeleton remained intact. Although secretion persisted with normal kinetics, it was evenly distributed in response to wounding rather than directed to the wound edge. Strikingly, these cells also completely failed to polarize. Further, directionally persistent cell migration was inhibited such that wound closure was impaired. These findings not only reveal novel roles for golgin-160 and GMAP210 in conferring membrane motility but also indicate that Golgi positioning has an active role in directed secretion, cell polarity, and wound healing

    Analysis of damping rate measurements of toroidal Alfven eigenmodes on JET as a function of n: part I

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    Kink instabilities in high-beta JET advanced scenarios

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    Integration of a radiative divertor for heat load control into JET high triangularity ELMy H-mode plasmas

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    Fusion yield measurements on JET and their calibration

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    Experimental results with an optimized magnetic field configuration for JET breakdown

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    Large ELM-like events triggered by core MHD in JET advanced tokamak plasmas: impact on plasmas profiles, plasma-facing components and heating systems

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    Experimental investigation of the confinement of d(He-3,p)alpha and d(d,p)t fusion reaction products in JET

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    Deuterium beam acceleration with 3rd harmonic ion cyclotron resonance heating in Joint European Torus: Sawtooth stabilization and Alfven eigenmodes

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