Is stereotactic large-core needle biopsy beneficial prior to surgical treatment in BI-RADS 5 lesions?

Introduction. Due to screening mammography, more nonpalpable mammographic lesions warrant histological evaluation. Stereotactic large-core needle biopsy (SLCNB) has been shown to be as effective in diagnosing these lesions as diagnostic surgical excision, and has become the preferred diagnostic procedure for most mammographic lesions. Since radiologically malignant BI-RADS 5 lesions are almost always carcinoma, some centers advocate prompt diagnostic surgical excision for these lesions instead of SLCNB. For some patients this diagnostic surgical intervention may serve as definitive treatment. We set out to find a subgroup of mammographic BI-RADS 5 lesions for which surgical biopsy might be preferable. Methods. Of 1644 consecutive nonpalpable lesions referred for SLCNB between April 1997 and May 2002, 238 were classified as BI-RADS 5. We assessed the number of carcinomas and the surgical interventions performed. Outcomes were compared between various types of mammographic lesions: density with calcifications, density without calcifications, and calcifications only. Different theoretical strategies for diagnostic work-up of BI-RADS 5 lesions were explored. Results. Carcinoma was found in 229/238 lesions (96%). Most mammographic densities were invasive cancer (97%), while calcifications only showed the highest risk for DCIS (51%). In our study ( current practice) all lesions were scheduled to first undergo SLCNB. A scenario was proposed where all lesions with only a density would be scheduled directly for sentinel node biopsy (SNB) and tumour excision (n = 154; 65%), while other lesions would still be scheduled for SLCNB. When we compared this scenario to current practice, four out of 238 patients (<2%) would be 'overtreated' with SNB. Conclusions. Our findings confirm a high predictive value of malignancy for BI-RADS 5 lesions ( 96%). Surgical excision is therefore imperative for all BI-RADS 5 lesions, irrespective of SLCNB results. For BI-RADS 5 lesions presenting as mammographic densities only, we propose to consider surgical excision with SNB to be the first diagnostic and therapeutic procedure. SLCNB is preferred in all other cases

Major liver resection results in a changed plasma amino acid pattern as reflected by a decreased Fischer ratio which improves by bactericidal/permeability increasing protein

Background/Aims: Major liver resection results in a high morbidity and mortality, and endotoxin plays a role in post-resection hepatic failure. Severe hepatic failure as seen in hepatitis and cirrhosis may be accompanied by hepatic encephalopathy and is characterized by a typical plasma amino acid pattern reflected by a decreased Fischer ratio. This study was performed to evaluate the plasma amino acid pattern in patients undergoing major liver surgery receiving placebo or the endotoxin-neutralizing agent bactericidal/permeability-increasing protein (rBPI(21)) Patients and methods: Forty-eight patients were randomized in this phase II, dose escalation, multicenter trial. Plasma amino acid profiles were determined preoperatively, and on the first (day 1) and third (day 3) postoperative day. Results. In the placebo group the Fischer ratio decreased significantly on both postoperative days. Administration of rBPI(21) also resulted in a decreased Fischer ratio on day 1, but not on day 3. Highly elevated alanine plasma levels were observed on day 1 in placebo-treated patients, whereas rBPI21 prevented this elevation. Plasma alanine levels on day 1 correlated with the duration of post-resection hepatic failure. Conclusions: Major liver resection results in a decreased Fischer ratio and a rise in plasma alanine levels. Plasma levels of alanine on the first postoperative day correlated with the duration of the post-resection hepatic failure. rBPI(21) improved the Fischer ratio and prevented the rise of plasma alanine levels

Coagulopathy following major liver resection: The effect of rBPI(21) and the role of decreased synthesis of regulating proteins by the liver

This prospective study investigated the role of reduced hepatic synthesis of regulating proteins in coagulopathy after partial hepatectomy (PH) compared with major abdominal surgery (MAS) without involvement of the liver. Furthermore, we studied the effect of rBPI(21), an endotoxin-neutralizing agent, on coagulopathy after PH was studied. Compared with MAS, PH resulted in significantly elevated levels of thrombin-antithrombin-lll and plasmin-alpha2-antiplasmin complexes. Levels of antithrombin-3, alpha2-antiplasmin, fibrinogen, plasminogen, alpha2-macroglobulin (alpha2-M), and C1-inhibitor remained lower following PH. Treatment with rBPI(21) led to significantly lower levels of tissue-type plasminogen activator (t-PA). Post-operative disseminated intravascular coagulation (DIC) was associated with significantly higher bilirubin and t-PA plasma levels and significantly lower levels of alpha2-M. This study indicates that PH induced hepatic failure results in decreased synthesis of hepatic regulating plasma proteins and subsequent activation of coagulation and fibrinolysis. Prevention of t-PA release by rBPI(21) may have important clinical implications. Decreased availability of alpha2-M may be a factor in post-operative DIG