A various equation of state for anisotropic models of compact star

We obtain models of compact stars having pressure anisotropy on Finch-Skea spacetime by considering generalized equation of state (EoS), whose particular cases are linear, quadratic, polytropic, chaplygin and colour - flavor locked(CFL) equation of states. The physical viability of models are tested for strange star candidate 4U 1820 - 30 having mass M = 1.58Mass of the sun and radius R = 9.1 km. All the models are physically plausible.Comment: 28 pages and 15 figure

Anisotropic Approach: Compact star as generalized Model

We studied a new class of interior solutions that are singular-free and useful for describing anisotropic compact star objects with spherically symmetric matter distribution. We have considered metric potential selecting B_0^2 (r)=1/(1-r^2/R^2 )^n ,where n>2 . The various physical characteristics of the model are specifically examined for the pulsar PSRJ1903+327 with its current estimated data. According to analysis, every physical need for a physically admissible star is satisfied and all features are acceptable. Further, the stability of the model has been examined. Numerous physical characteristics are also highlighted in a graphical form.Comment: 20 pages and 14 figure

New charged anisotropic solution on paraboloidal spacetime

New exact solutions of Einstein's field equations for charged stellar models by assuming linear equation of state $P_r=A(\rho-\rho_{a})$, where $P_r$ is the radial pressure and $\rho_{a}$ is the surface density. By assuming $e^{\lambda} = 1+\frac{r^2}{R^2}$ for metric potential. The physical acceptability conditions of the model are investigated, and the model is compatible with several compact star candidates like 4U 1820-30, PSR J1903+327, EXO 1785-248, Vela X-1, PSR J1614-2230, Cen X-3. A noteworthy feature of the model is that it satisfies all the conditions needed for a physically acceptable model.Comment: 29 Pages, 12 Figures, 3 Table

Generalized Finch and Skea model compatible with observational data

We present an entirely new class of solutions to Einstein's field equations that correspond to a static spherically symmetric anisotropic system by generalizing the Finch and Skea ansatz using the linear equation of state for the gravitational potential $g_{rr}$. Based on physical requirements, regularity condition, and stability, we make various assumptions about the model's parameters. The exact solution generates a plausible model of a compact star PSR J0348+0432 that satisfies all physical criteria. The requirements for a well-behaved compact star are met, including regularity, equilibrium, causality, stability, energy, and compactness limitations.Comment: 24 Pages, 20 Figures, 3 Table

Diagnostic accuracy of Lung Biopsy and Bronchoalveolar Lavage (BAL) in Lung Malignancy

Objective: The study was designed to correlate histopathology of lung biopsy and bronchoalveolar lavage (BAL) cytology in the diagnosis of lung malignancy and to determine the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of bronchoalveolar lavage cytology using histopathology of lung biopsy as gold standard. Study Design: The retrospective and prospective study was conducted at Pathology Department of Tertiary care centre from October 2017 to October 2019, to investigate a total of 54 patients who were clinically/radiologically suspected of lung malignancy and who underwent both bronchial biopsy and bronchoalveolar lavage. Results: On histopathological examination of biopsies, 29 cases (53.7%) were malignant whereas on cytological examination of BAL 19 cases (35.18%) were correctly diagnosed as malignant and 4 cases (7.4%) as suspicious/atypical. The sensitivity, specificity, PPV, NPV and overall diagnostic accuracy of BAL was 79.3%, 100%, 100%, 86.2% and 88.9% respectively. Conclusion: It was observed that BAL cytology is sensitive and specific for the diagnosis of lung cancer. Cytopathological examination complements histopathology in both diagnosing and typing of lung tumours

The Prevalence of clotting factor inhibitors in patients with hemophilia

Background: Hemophilia A and B are X-linked diseases that predominantly affect male patients. Patients can develop coagulation factor inhibitors, which exponentially increases the treatment cost. Objective: This study aimed to determine the prevalence of factor VIII inhibitors. Materials and methods: This was an observational descriptive study. Clotting factor inhibitor screening was performed by activated partial thromboplastin time mixing studies using normal pooled plasma. Bethesda assay for quantitation of factor VIII inhibitors was performed on samples which were positive with screening tests.Results: Study was performed in total of 62 patients with Hemophillia. Out of 62 patients, Hemophilia A and Hemophilia B was observed in 92% cases and 7% cases respectively and 1 case was with Hemophillia and von willebrand disease(1%). Out of 62 patients, 39(63%) had severe hemophilia A, 18(29%) had moderate hemophilia A, and 5(8%) had mild hemophilia A. Mixing based inhibitor screening was positive in total 14 number of patients. Bethesda assay confirmed 10(16%) cases with presence of inhibitor. 4(40%) out of 10 patients were low responders (<5 BU), with mean BU of 2.88, and 6(60%) patients were high responders (>5 BU), with mean BU of 39.2. Diagnostics of mixing based inhibitor screening showed sensitivity and specificity of 75% & 60% at difference of ≥5 seconds and 60% & 100% for difference of ≥10 seconds.Conclusion: Mixing tests are an important first step in the investigation of inhibitors in cases with hemophilia as the follow up investigations are more costly and time consuming than the basic screening tests