476 research outputs found
Foundations in Wisconsin: A Directory [32nd ed. 2013]
The 2013 edition of Foundations in Wisconsin marks the 32nd production of the print directory and the 13th year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation websites, annual reports, and newsletters.https://epublications.marquette.edu/lib_fiw/1011/thumbnail.jp
Self-similar structure and experimental signatures of suprathermal ion distribution in inertial confinement fusion implosions
The distribution function of suprathermal ions is found to be self-similar
under conditions relevant to inertial confinement fusion hot-spots. By
utilizing this feature, interference between the hydro-instabilities and
kinetic effects is for the first time assessed quantitatively to find that the
instabilities substantially aggravate the fusion reactivity reduction. The ion
tail depletion is also shown to lower the experimentally inferred ion
temperature, a novel kinetic effect that may explain the discrepancy between
the exploding pusher experiments and rad-hydro simulations and contribute to
the observation that temperature inferred from DD reaction products is lower
than from DT at National Ignition Facility.Comment: Revised version accepted for publication in PRL. "Copyright (2015) by
the American Physical Society.
Foundations in Wisconsin: A Directory [31st ed. 2012]
The 2012 release of Foundations in Wisconsin marks the 31st edition of the print directory and the twelfth year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation Web sites, annual reports, and newsletters.
Fortunately, Wisconsin foundations are rebounding from the recent economic downturn. While the total number of active foundations (1301) decreased slightly from 2011’s high number, 57 new foundations were identified and two key measures show positive growth. Total assets increased by 12% from last year to over 490 million, close to pre-recession totals. The following table illustrates the 10-year financial pattern as documented in Foundations in Wisconsin.https://epublications.marquette.edu/lib_fiw/1010/thumbnail.jp
Foundations in Wisconsin: A Directory [33rd ed. 2014]
The 2014 release of Foundations in Wisconsin marks the 33rd edition of the print directory and the 14th year of the online version. The directory is designed as a research tool for grantseekers interested in locating information on private, corporate, and community foundations registered in Wisconsin. Each entry in this new edition has been updated or reviewed to provide the most current information available. Most of the data was drawn from IRS 990-PF tax returns filed by the foundations. Additional information was obtained from surveys, foundation websites, annual reports, and newsletters.https://epublications.marquette.edu/lib_fiw/1012/thumbnail.jp
Assessment of ion kinetic effects in shock-driven inertial confinement fusion implosions using fusion burn imaging
The significance and nature of ion kinetic effects in D3He-filled, shock-driven inertial confinement
fusion implosions are assessed through measurements of fusion burn profiles. Over this series of
experiments, the ratio of ion-ion mean free path to minimum shell radius (the Knudsen number,
NK) was varied from 0.3 to 9 in order to probe hydrodynamic-like to strongly kinetic plasma
conditions; as the Knudsen number increased, hydrodynamic models increasingly failed to match
measured yields, while an empirically-tuned, first-step model of ion kinetic effects better captured
the observed yield trends [Rosenberg et al., Phys. Rev. Lett. 112, 185001 (2014)]. Here, spatially
resolved measurements of the fusion burn are used to examine kinetic ion transport effects in
greater detail, adding an additional dimension of understanding that goes beyond zero-dimensional
integrated quantities to one-dimensional profiles. In agreement with the previous findings, a comparison
of measured and simulated burn profiles shows that models including ion transport effects
are able to better match the experimental results. In implosions characterized by large Knudsen
numbers (NK3), the fusion burn profiles predicted by hydrodynamics simulations that exclude
ion mean free path effects are peaked far from the origin, in stark disagreement with the experimentally
observed profiles, which are centrally peaked. In contrast, a hydrodynamics simulation that
includes a model of ion diffusion is able to qualitatively match the measured profile shapes.
Therefore, ion diffusion or diffusion-like processes are identified as a plausible explanation of the
observed trends, though further refinement of the models is needed for a more complete and
quantitative understanding of ion kinetic effects
Neutron time-of-flight measurements of charged-particle energy loss in inertial confinement fusion plasmas
Neutron spectra from secondary ^{3}H(d,n)α reactions produced by an implosion of a deuterium-gas capsule at the National Ignition Facility have been measured with order-of-magnitude improvements in statistics and resolution over past experiments. These new data and their sensitivity to the energy loss of fast tritons emitted from thermal ^{2}H(d,p)^{3}H reactions enable the first statistically significant investigation of charged-particle stopping via the emitted neutron spectrum. Radiation-hydrodynamic simulations, constrained to match a number of observables from the implosion, were used to predict the neutron spectra while employing two different energy loss models. This analysis represents the first test of stopping models under inertial confinement fusion conditions, covering plasma temperatures of k_{B}T≈1-4  keV and particle densities of n≈(12-2)×10^{24}  cm^{-3}. Under these conditions, we find significant deviations of our data from a theory employing classical collisions whereas the theory including quantum diffraction agrees with our data
Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3
Vascular endothelial growth factor C (VEGF-C) is a key mediator of lymphangiogenesis, acting via its receptors VEGF-R2 and VEGF-R3. High expression of VEGF-C in tumors correlates with increased lymphatic vessel density, lymphatic vessel invasion, sentinel lymph node metastasis and poor prognosis. Recently, we found that in a chemically induced skin carcinoma model, increased VEGF-C drainage from the tumor enhanced lymphangiogenesis in the sentinel lymph node and facilitated metastatic spread of cancer cells via the lymphatics. Hence, interference with the VEGF-C/VEGF-R3 axis holds promise to block metastatic spread, as recently shown by use of a neutralizing anti-VEGF-R3 antibody and a soluble VEGF-R3 (VEGF-C/D trap). By antibody phage-display, we have developed a human monoclonal antibody fragment (single-chain Fragment variable, scFv) that binds with high specificity and affinity to the fully processed mature form of human VEGF-C. The scFv binds to an epitope on VEGF-C that is important for receptor binding, since binding of the scFv to VEGF-C dose-dependently inhibits the binding of VEGF-C to VEGF-R2 and VEGF-R3 as shown by BIAcore and ELISA analyses. Interestingly, the variable heavy domain (VH) of the anti-VEGF-C scFv, which contains a mutation typical for camelid heavy chain-only antibodies, is sufficient for binding VEGF-C. This reduced the size of the potentially VEGF-C-blocking antibody fragment to only 14.6 kDa. Anti-VEGF-C VH-based immunoproteins hold promise to block the lymphangiogenic activity of VEGF-C, which would present a significant advance in inhibiting lymphatic-based metastatic spread of certain cancer types
Terawatt, Joule-Class Pulsed THz Sources from Microchannel Targets
Production of terawatt, joule class THz radiation sources from microchannel
targets driven with 100s of joule, picosecond lasers is reported. THz sources
of this magnitude are useful for non-linear pumping of matter and for charged
particle acceleration and manipulation. Microchannel targets demonstrate
increased conversion efficiency compared to planar foil targets, with laser
energy to THz energy conversion up to 0.9 percent.Comment: 9 pages, 2 figure
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