エンカク ニヨル ニホンゴ ジュギョウ カンサツ ト キョウドウ ガクシュウ ヲ トオシタ ニホンゴ キョウシ ヨウセイ ノ ココロミ

新型コロナウイルス感染症の流行により、教育現場ではオンライン対応が進んでいる。このような状況であっても学びの質を高めるべく、大阪大学日本語日本文化教育センター（CJLC）の遠隔オンライン授業見学システムを用い、CJLC、愛知県立大学、京都産業大学の合同による日本語授業観察と協働学習を実施した。本実践は、①観察課題設定、②遠隔オンライン授業見学、③オンライン合同ディスカッションの順で行った。そして、この実践をふまえ、①～③の各段階における学生の記述を分析し、彼らの気づきと学びの変化を考察した。③の記述では、複数の大学の協働学習を通して、異なる学習段階にある学生と日本語学習者が話し合い、複数の日本語教師の考えを聞くことで、学生は自身の捉え方にさまざまな視点を交差させ理解を深めていた。異なる学習段階にある、異なる視点を持つ学生との協働学習がオンライン授業見学という手段により可能となり、本実践の方法は日本語教育の多様性の理解を促す日本語教師養成の一手法として有効であると考えられる

L-Serine-Modified Poly-L-Lysine as a Biodegradable Kidney-Targeted Drug Carrier for the Efficient Radionuclide Therapy of Renal Cell Carcinoma

In the present study, L-serine (Ser)-modified poly-L-lysine (PLL) was synthesized to develop a biodegradable, kidney-targeted drug carrier for efficient radionuclide therapy in renal cell carcinoma (RCC). Ser-PLL was labeled with 111In/90Y via diethylenetriaminepentaacetic acid (DTPA) chelation for biodistribution analysis/radionuclide therapy. In mice, approximately 91% of the total dose accumulated in the kidney 3 h after intravenous injection of 111In-labeled Ser-PLL. Single-photon emission computed tomography/computed tomography (SPECT/CT) imaging showed that 111In-labeled Ser-PLL accumulated in the renal cortex following intravenous injection. An intrarenal distribution study showed that fluorescein isothiocyanate (FITC)-labeled Ser-PLL accumulated mainly in the renal proximal tubules. This pattern was associated with RCC pathogenesis. Moreover, 111In-labeled Ser-PLL rapidly degraded and was eluted along with the low-molecular-weight fractions of the renal homogenate in gel filtration chromatography. Continuous Ser-PLL administration over five days had no significant effect on plasma creatinine, blood urea nitrogen (BUN), or renal histology. In a murine RCC model, kidney tumor growth was significantly inhibited by the administration of the beta-emitter 90Y combined with Ser-PLL. The foregoing results indicate that Ser-PLL is promising as a biodegradable drug carrier for kidney-targeted drug delivery and efficient radionuclide therapy in RCC

Low room temperature can trigger ventricular fibrillation in J wave syndromes

Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

A novel HECW2 variant in an infant with congenital long QT syndrome

Abstract Pathogenic variants of HECW2 have been reported in cases of neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL; OMIM #617268). A novel HECW2 variant (NM_001348768.2:c.4343 T > C,p.Leu1448Ser) was identified in an NDHSAL infant with severe cardiac comorbidities. The patient presented with fetal tachyarrhythmia and hydrops and was postnatally diagnosed with long QT syndrome. This study provides evidence that HECW2 pathogenic variants can cause long QT syndrome along with neurodevelopmental disorders