CLINICAL COMPARISON OF TYMPANIC MEMBRANE PERFORATION CLOSURE WITH TRICHLOROACETIC ACID AND APAMARGA KSHARA (ACHYRANTHES ASPERA LINN. ALKALINE EXTRACT)

Tympanic membrane perforations are broadly pathological and traumatic in origin. The fibrosed rim of perforation and medially migrated epithelial layer of the perforated membrane offers a cauterization opportunity which conspicuously breaks the epithelial barrier, dissolves necrosed tissue over growth and enhances neo membrane formation. Trichloroacetic acid chemical cautery and patching is used from decades in order to reconstitute the tympanic membrane integrity with a successful rate hovering around 85-92% in various clinical studies. Nowhere in the classical Ayurveda texts or in the modern literature Apamarga Kshara (Achyranthes aspera Linn. alkaline extract) paste cauterization is used for re-epithelialization of the tympanic membrane although its tissue generative properties and antimicrobial traits are quite well documented. 34 tympanic membrane perforation patients after ramifying them into two groups were selected for the present clinical study which intends to compare the effectiveness of tympanic membrane perforation closure by application of trichloroacetic acid vis-a-vis application of Achyranthes aspera alkaline extract on the margins of the perforation. Achyranthes aspera alkaline extract for the current clinical trial as a trial drug has its proven tissue regeneration and vasoproliferative properties which is an indispensible prerequisite in any attempt to restore the integrity of a perforated tympanic membrane, also its antimicrobial and vasoproliferative capacity also compliments the selection of Achyranthes aspera alkaline extract. This cauterization with Apamarga Kshara was found to be quite effective as the results were encouraging and can successfully be advocated as an Ayurvedic cauterization substitute for the resurfacing of the ruptured tympanic membrane.

Optimization of <i>Parisheka kriyakalpa</i> (procedure for closed eye irrigation) 3: A clinical study on acute conjunctivitis with <i>Triphala</i> decoction

107-112Scientific validation of any drug, therapy, protocol or procedure requires a standardized procedure of manufacturing process, execution of the protocol or therapeutic procedure for standardization if the formulation protocol or procedure has variables in literature and practice; they need to be optimized first following a systematic approach with prospective clinical application for further validation of the optimized data. Netra Parisheka/Seka foremost topical ocular therapeutic procedure had similar prevalence of variability in literature and practice. To meet the above criteria and to achieve the objective of standardization; optimization of SOP of Netra Parisheka procedure was thought to be the pre-requisite. Using all adopted parameters, total 51 (68 eyes) patients were enrolled out of which 50 (67 eyes) patients completed the study. Highly significant result with P value > 0.001 of Netra Parisheka procedure for a period of four days in dose of 750 ml, 500 ml & 250 ml for Vata, Pitta & Kaphaja Netra roga, respectively, temperature 37.2–37.7 oC, height 6-6.5 cm, duration 5–15 min, width 1.5-2.0 mm in Aamavastha of Netra roga (acute inflammatory condition of the eye) and shows its definite role of the procedure in the conversion of Aamavastha to Niraamavastha (remission of acute inflammatory sign) after 4th day. In some cases complete remission of symptoms was observed, i.e., 40%, while more than 70 % patients were having improvement in their signs and symptoms

Clinical Aspect of Diseases of Cornea in Ayurveda

Introduction: There are total seventy sixocular diseases described in Sushruta Samhita and 94 diseases in Astanga Sangrah &amp; Astanga Hridya. This concept of classification of ocular disorders is well buttressed by classifying the disease as Sandhigata (Diseases affecting junctional areas of eye), Vartamagata (Diseases of eyelids), Shuklagata (Diseases of Sclera plus Conjunctiva), Krishnagata (Diseases of Cornea), Sarvagata (Diseases affecting all parts of Eye), Drishtigata (Diseases of Lens). Material and Methods: Extensive literary review of various text of Ayurveda in order to carve out a possible comparison of Ayurvedic Corneal Ophthalmological disorders with modern counterpart. Aims: To establish clinical correlation between diseases of Krishna mandala to disease of the cornea. Discussion: Classifications of corneal diseases in classical Ayurvedic texts are sequential and progressive in nature viz. one condition progress to the next corresponding stage. Acharya Sushruta described 4 types of diseases of cornea while Vagbhatta has enumerated 5 types. A conscious endeavor is made to correlate the Ayurvedic and modern corneal disorders in a complimentary manner. Conclusion: The congruent behavior of corneal disorders of Ayurved and modern is justified by the clinical symptomology, progression of the disease, prognostic reasons and relevant intervention. The integrated disease approach, treatment application and predicting prognosis will suffice the resultant outcome of the disease in a more favorable perspective which will herald a better approach in managing preventable corneal blindness.Â

A Persuasive in the Management of Indralupta (Alopecia areata) with Ayurvedic approach

The aim of the case study is to evaluate the efficacy of Leech therapy along with ayurvedic treatment in Alopecia areata (INDRALUPTA). It is prospective interventional case report on alopecia areata treated with leech therapy and ayurvedic formulations. Using a subjective evaluation, an improvement in growth of hair on bald patches over scalp region was observed. An 18-year-old female patient, resident of Delhi, presented with complaints of two bald patches (right parietal &amp; vertex) over the scalp without any secondary changes. With these complaints, the patient visited Shalya Tantra, Outpatient department (OPD No 16) at Chaudhary Brahm Prakash Ayurved Charak Sansthan, New Delhi. She took treatment for six weeks and got complete remission in her symptoms. Line of treatment adopted was tridosha shamaka, rakta-shodhaka and raktamokashana (Leech application). Leech therapy supplemented with ayurvedic formulations have definite role in Alopecia Areata (Indralupta) especially of recent origin. A case series or pilot study may further strengthen above case report and open new treatment arena for such cases. This case report can also be used to formulate hypothesis for management of baldness from an ayurvedic perspective