De Novo Ovarian squamous cell carcinoma : A case of rare malignancy

Abstract Pure primary squamous cell carcinoma of the ovary, not associated with pre-existing ovarian lesions like dermoid cyst, Brenner tumours, or endometriosis is extremely rare. A 28 year old nulliparous female presented with acute pain in left lower abdomen and weight loss. Ultrasonography showed a mass arising from left ovary. An ovarian mass adhered to lateral pelvic wall was found on laprotomy. Histopathology confirmed the diagnosis of squamous cell carcinoma of left ovary with no co-existing ovarian dermoid. Postoperatively patient died within 8 weeks despite adjuvant chemotherapy

Can diabetes with controlled glycemic status cause placental changes and affect foetal outcome? A histomorphology study from a tertiary care centre from Eastern India

Background: Normal foetal development and postnatal survival depends on healthy placenta. The adverse effects of diabetes on pregnancy and related foetal outcomes are well established and through this study we have attempted to study the intensity of damage caused, by examining the gross and microscopic features of placenta along with histochemical changes. Material and Methods: This was a prospective study undertaken in a tertiary teaching hospital in which a total of 80 cases of term pregnancy were studied, out of which 40 were from diabetic mothers and 40 were from non diabetic mothers. Biochemical parameters of all the cases were studied. All placenta were examined on the basis of gross features, histological & histochemical changes. Results: In the present study, it was noted that gross morphology of placenta was not much altered between diabetic and normal mothers but showed marked variation in the histological findings. On microscopic examination, marked basement membrane thickening, vascular proliferation, chorangiosis, syncytial knots, villous fibrosis and edema were noted among diabetic mothers and most common postnatal complication of newborns among diabetic mothers was macrosomia. Conclusion: This study highlights the impact of gestational and pregestational diabetes mellitus on placenta as observed by the magnitude of histological changes inspite of having controlled glycemic status either by diet or insulin and associated postnatal morbidities of newborns

Massive ovarian edema: A case report presenting as a diagnostic dilemma

Massive ovarian edema is a rare clinical entity, posing a significant clinical challenge as it can be easily mistaken for neoplasm. Our case was a 20-year-old young woman who presented with a self-limiting episode of abdominal pain along with large solid pelvis mass. On physical examination, she had abdominal tenderness with guarding. Ultrasound examination revealed large solid ovarian mass with moderate ascites. With the diagnosis of ovarian neoplasm, laparotomy was performed, and intraoperative frozen section excluded malignancy with differentials suggesting of fibromatosis/massive ovarian edema. The patient underwent unilateral salpingo-oophorectomy. Histopathological examination confirmed the diagnosis of massive ovarian edema. Massive ovarian edema should be suspected in women at the fertility age range with solid enlargement of the ovary so that these young patients can be treated conservatively where fertility preservation is mandatory

Trends in Cytomorphological Study of Thyroid lesions: A two year prospective study in the malwa region of central India

Background: Thyroid lesions are commonly encountered in daily clinical practice. However, excision of thyroid lesions is associated with risk. Hence an effective preliminary test is needed to avoid unnecessary surgery. An assessment of thyroid lesion by FNAC has proved to provide early diagnosis and hence helps in avoiding invasive surgery. Aims and Objectives: The purpose of present study was to study various cytomorphological features of thyroid lesions in the tertiary teaching hospital of Malwa region with respect to age, sex and to categorize them into neoplastic and non-neoplastic lesions. Materials and methods: FNAC was performed on patients who presented with thyroid swelling in department of pathology of Sri Aurobindo Medical College and PG Institute, from 1st January 2014 to 31st December 2015. Results: Out of 186 patients in our study group 161(86.56%) were benign, 23(12.37%) were malignant and 2 were inconclusive. Benign follicular lesion 108 (67%) was commonest under non-neoplastic category and follicular neoplasm 19 (82.6%) under neoplastic category. Male to female ratio was 1:4. Conclusion: FNAC plays an important role in thyroid lesions as it is safe, cost effective and also helps in selections of patients for surgery, thus minimizing risk associated with surgery