Evaluation of the efficacy of endovascular treatment of pelvic congestion syndrome

AbstractAimTo assess the efficacy of venous embolization treatment for the pelvic congestion syndrome (PCS).Patients and methodsRetrospective study of 33 female patients undergoing pelvic venous embolization between January 2008 and May 2012 in Bordeaux. The inclusion criteria were clinical symptoms of PCS documented by transabdominal Doppler ultrasound and/or pelvic magnetic resonance imaging. Patients with pelvic varicose veins feeding saphenous varicose veins were excluded. The efficacy of treatment was assessed on a Visual Analog Scale (VAS).ResultsThirty-three patients were included and the mean follow up period was 26months (3–59months). The VAS was 7.37 (standard deviation: 0.99) before embolization and 1.36 (standard deviation: 1.73) after embolization (P<0.0001). Twenty patients reported that their symptoms had completely disappeared, 11 had partially disappeared and two had gained no improvement. A significant fall was found in the number of patients with dyspareunia (P<0.0001). A single technical embolization failure was reported.ConclusionOur series demonstrates the efficacy of embolization treatment with a significant fall in the VAS in patients with PCS

Manganese Enhances Prion Protein Survival in Model Soils and Increases Prion Infectivity to Cells

Prion diseases are considered to be transmissible. The existence of sporadic forms of prion diseases such as scrapie implies an environmental source for the infectious agent. This would suggest that under certain conditions the prion protein, the accepted agent of transmission, can survive in the environment. We have developed a novel technique to extract the prion protein from soil matrices. Previous studies have suggested that environmental manganese is a possible risk factor for prion diseases. We have shown that exposure to manganese is a soil matrix causes a dramatic increase in prion protein survival (∼10 fold) over a two year period. We have also shown that manganese increases infectivity of mouse passaged scrapie to culture cells by 2 logs. These results clearly verify that manganese is a risk factor for both the survival of the infectious agent in the environment and its transmissibility

The pandemic and wellbeing: Views from tourism employees

This study sought to investigate wellbeing through the lens of people who have experienced the impacts of Covid-19 while working in an industry that was impacted severely by the effects of the pandemic. Study findings reveal the important and rather neglected role of the “sense of freedom” while examining, evaluating and fostering the wellbeing of individuals. This outcome has both societal, and tourism managerial implications

Evaluation of the inherent capacity of commercial yeast strains to release glycosidic aroma precursors from Muscat grape must

Background and AimsThe aim of this work was to establish a general method for evaluating the intrinsic activity of yeasts towards the release of volatiles terpenes from glycosidic aroma precursors. Methods and ResultsThe enzymatic capacity of yeast cells towards glycosidic aroma precursors was assessed on permeabilised yeast cells. In this way, the pores created into the cell membrane allowed the precursors to freely enter the cells. ConclusionsThe comparison between the release of terpenes from glycosidic aroma precursors by entire viable cells during fermentation and by permeabilised cells shows that the permeation of glycosidic aroma precursors through the yeast cell membrane is the main bottleneck for such release. Significance of the StudyThis work highlights the fact that Saccharomyces species can exhibit -glycosidase activity as high as non-Saccharomyces species. This important result points out future prospects for the improvement of Saccharomyces species by classical genetics

Removal of biogenic amines from wines by chemisorption on functionalized silica and effects on other wine components

The effectiveness of several functionalized silica materials (cation-exchange materials) for the removal of biogenic amines from wines, and the effects on other wine components and organoleptic characteristics were evaluated. Results have shown that mesoporous silica material bi-functionalized with phosphonic and sulfonic acids allowed the removal of histamine, putrescine, cadaverine, spermine and spermidine from wines, although the dose must be adapted for each wine according to the removal requirements and wine characteristics. A plus of the adsorbent developed is that it can be recovered and re-used for at least 3 treatments. Immediately following the treatments, a decrease in the levels of linear ethyl esters (ethyl hexanoate, ethyl octanoate and ethyl decanoate) was observed, although these levels were re-equilibrated after several days reducing this undesired side effect. A slight, but perceptible, effect on wine color was observed, probably due to the slight decrease in the pH of the wine produced by the treatments. On the basis of the sensory analysis that focused only on the aroma of the wines, the proposed technique would be more adequate for wines aged in barrels than for young winesDepto. de Química AnalíticaFac. de Ciencias QuímicasTRUEpu

Algorithms based on medico-administrative data in the field of endocrine, nutritional and metabolic diseases, especially diabetes

National audienceBackground. - Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field. Methods. - Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described. Results. - Three algorithms for identifying people with diabetes are available in France. These algorithms are based either on full insurance coverage for diabetes or on claims of diabetes treatments, or on the combination of these two methods associated with hospitalizations related to diabetes. Each of these algorithms has a different purpose, and the choice should depend on the goal of the study. Algorithms for identifying people treated for dyslipidemia or precocious puberty or who underwent bariatric surgery are also available. Conclusion. - Early work from the Redsiam working group in the field of endocrine, nutritional and metabolic diseases produced an inventory of existing algorithms in France, linked with their goals, together with a presentation of their limitations and advantages, providing useful information for the scientific community. This work will continue with discussions about algorithms on the incidence of diabetes in children, thyroidectomy for thyroid nodules, hypothyroidism, hypoparathyroidism, and amyloidosis

Le polyéthylène téréphtalate, un emballage pour le vin ? Partie 1/2 : propriétés barrière, sécurité sanitaire, analyse du cycle de vie

National audienceUn programme de recherche collaborative, le projet NOVINPAK®, s’est déroulé de décembre 2010 à Juin 2014 afin de proposer un conditionnement innovant. L’objectif était de développer une solution allégée en PET monocouche, 100% recyclable, incluant 25% de PET-recyclé minimum qui s’insère au mieux dans les filières de recyclage et de valorisation actuelles et qui possède des propriétés barrières optimales vis-à-vis de l’oxygène et des arômes pour assurer le maintien de la qualité du vin dans le temps. Ce programme, de recherche financé par le Fond Unique Interministériel, et réalisé par les industriels VAL d’ORBIEU–UCCOAR en tant que chef de file, SIDEL et PURE ENVIRONNEMENT en collaboration avec des partenaires de recherche institutionnels, a permis de développer une solution éco-conçue de bouteilles de vin en PET pour vin de qualité. Sont présentés ici les principaux résultats de cette étude, sur les axes matériaux (allègement, intégration de PET-recyclé, intégration de barrières à l’oxygène dans le PET monocouche), les résultats des tests de migration pour la sécurité sanitaire ainsi que les résultats de l’analyse du cycle de vie (ACV). Un second article présentera plus en détails, l’évolution des gaz, du SO2 et les analyses sensorielles effectuées en comparaison à un conditionnement de référence, la bouteille en verre 75cL, tout au long du stockage sur 12 mois